Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group

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Meta-analysis of chemotherapy in head and neck cancer (MACH-NC) : An update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group. / Lacas, Benjamin; Carmel, Alexandra; Landais, Cécile; Wong, Stuart J.; Licitra, Lisa; Tobias, Jeffrey S.; Burtness, Barbara; Ghi, Maria Grazia; Cohen, Ezra E.W.; Grau, Cai; Wolf, Gregory; Hitt, Ricardo; Corvò, Renzo; Budach, Volker; Kumar, Shaleen; Laskar, Sarbani Ghosh; Mazeron, Jean Jacques; Zhong, Lai Ping; Dobrowsky, Werner; Ghadjar, Pirus; Fallai, Carlo; Zakotnik, Branko; Sharma, Atul; Bensadoun, René Jean; Ruo Redda, Maria Grazia; Racadot, Séverine; Fountzilas, George; Brizel, David; Rovea, Paolo; Argiris, Athanassios; Nagy, Zoltán Takácsi; Lee, Ju Whei; Fortpied, Catherine; Harris, Jonathan; Bourhis, Jean; Aupérin, Anne; Blanchard, Pierre; Pignon, Jean Pierre; MACH-NC Collaborative Group.

I: Radiotherapy and Oncology, Bind 156, 03.2021, s. 281-293.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Lacas, B, Carmel, A, Landais, C, Wong, SJ, Licitra, L, Tobias, JS, Burtness, B, Ghi, MG, Cohen, EEW, Grau, C, Wolf, G, Hitt, R, Corvò, R, Budach, V, Kumar, S, Laskar, SG, Mazeron, JJ, Zhong, LP, Dobrowsky, W, Ghadjar, P, Fallai, C, Zakotnik, B, Sharma, A, Bensadoun, RJ, Ruo Redda, MG, Racadot, S, Fountzilas, G, Brizel, D, Rovea, P, Argiris, A, Nagy, ZT, Lee, JW, Fortpied, C, Harris, J, Bourhis, J, Aupérin, A, Blanchard, P, Pignon, JP & MACH-NC Collaborative Group 2021, 'Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group', Radiotherapy and Oncology, bind 156, s. 281-293. https://doi.org/10.1016/j.radonc.2021.01.013

APA

Lacas, B., Carmel, A., Landais, C., Wong, S. J., Licitra, L., Tobias, J. S., Burtness, B., Ghi, M. G., Cohen, E. E. W., Grau, C., Wolf, G., Hitt, R., Corvò, R., Budach, V., Kumar, S., Laskar, S. G., Mazeron, J. J., Zhong, L. P., Dobrowsky, W., ... MACH-NC Collaborative Group (2021). Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group. Radiotherapy and Oncology, 156, 281-293. https://doi.org/10.1016/j.radonc.2021.01.013

CBE

Lacas B, Carmel A, Landais C, Wong SJ, Licitra L, Tobias JS, Burtness B, Ghi MG, Cohen EEW, Grau C, Wolf G, Hitt R, Corvò R, Budach V, Kumar S, Laskar SG, Mazeron JJ, Zhong LP, Dobrowsky W, Ghadjar P, Fallai C, Zakotnik B, Sharma A, Bensadoun RJ, Ruo Redda MG, Racadot S, Fountzilas G, Brizel D, Rovea P, Argiris A, Nagy ZT, Lee JW, Fortpied C, Harris J, Bourhis J, Aupérin A, Blanchard P, Pignon JP, MACH-NC Collaborative Group. 2021. Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group. Radiotherapy and Oncology. 156:281-293. https://doi.org/10.1016/j.radonc.2021.01.013

MLA

Vancouver

Author

Lacas, Benjamin ; Carmel, Alexandra ; Landais, Cécile ; Wong, Stuart J. ; Licitra, Lisa ; Tobias, Jeffrey S. ; Burtness, Barbara ; Ghi, Maria Grazia ; Cohen, Ezra E.W. ; Grau, Cai ; Wolf, Gregory ; Hitt, Ricardo ; Corvò, Renzo ; Budach, Volker ; Kumar, Shaleen ; Laskar, Sarbani Ghosh ; Mazeron, Jean Jacques ; Zhong, Lai Ping ; Dobrowsky, Werner ; Ghadjar, Pirus ; Fallai, Carlo ; Zakotnik, Branko ; Sharma, Atul ; Bensadoun, René Jean ; Ruo Redda, Maria Grazia ; Racadot, Séverine ; Fountzilas, George ; Brizel, David ; Rovea, Paolo ; Argiris, Athanassios ; Nagy, Zoltán Takácsi ; Lee, Ju Whei ; Fortpied, Catherine ; Harris, Jonathan ; Bourhis, Jean ; Aupérin, Anne ; Blanchard, Pierre ; Pignon, Jean Pierre ; MACH-NC Collaborative Group. / Meta-analysis of chemotherapy in head and neck cancer (MACH-NC) : An update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group. I: Radiotherapy and Oncology. 2021 ; Bind 156. s. 281-293.

Bibtex

@article{db39bbbcd8234d6195e7a0e87d029a01,
title = "Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group",
abstract = "Background and purpose: The Meta-Analysis of Chemotherapy in squamous cell Head and Neck Cancer (MACH-NC) demonstrated that concomitant chemotherapy (CT) improved overall survival (OS) in patients without distant metastasis. We report the updated results. Materials and methods: Published or unpublished randomized trials including patients with non-metastatic carcinoma randomized between 1965 and 2016 and comparing curative loco-regional treatment (LRT) to LRT + CT or adding another timing of CT to LRT + CT (main question), or comparing induction CT + radiotherapy to radiotherapy + concomitant (or alternating) CT (secondary question) were eligible. Individual patient data were collected and combined using a fixed-effect model. OS was the main endpoint. Results: For the main question, 101 trials (18951 patients, median follow-up of 6.5 years) were analyzed. For both questions, there were 16 new (2767 patients) and 11 updated trials. Around 90% of the patients had stage III or IV disease. Interaction between treatment effect on OS and the timing of CT was significant (p < 0.0001), the benefit being limited to concomitant CT (HR: 0.83, 95%CI [0.79; 0.86]; 5(10)-year absolute benefit of 6.5% (3.6%)). Efficacy decreased as patients age increased (p_trend = 0.03). OS was not increased by the addition of induction (HR = 0.96 [0.90; 1.01]) or adjuvant CT (1.02 [0.92; 1.13]). Efficacy of induction CT decreased with poorer performance status (p_trend = 0.03). For the secondary question, eight trials (1214 patients) confirmed the superiority of concomitant CT on OS (HR = 0.84 [0.74; 0.95], p = 0.005). Conclusion: The update of MACH-NC confirms the benefit and superiority of the addition of concomitant CT for non-metastatic head and neck cancer.",
keywords = "Chemotherapy, Head and Neck Cancer, Individual Patient Data, Meta-analysis, Radiotherapy, Randomised Clinical Trials",
author = "Benjamin Lacas and Alexandra Carmel and C{\'e}cile Landais and Wong, {Stuart J.} and Lisa Licitra and Tobias, {Jeffrey S.} and Barbara Burtness and Ghi, {Maria Grazia} and Cohen, {Ezra E.W.} and Cai Grau and Gregory Wolf and Ricardo Hitt and Renzo Corv{\`o} and Volker Budach and Shaleen Kumar and Laskar, {Sarbani Ghosh} and Mazeron, {Jean Jacques} and Zhong, {Lai Ping} and Werner Dobrowsky and Pirus Ghadjar and Carlo Fallai and Branko Zakotnik and Atul Sharma and Bensadoun, {Ren{\'e} Jean} and {Ruo Redda}, {Maria Grazia} and S{\'e}verine Racadot and George Fountzilas and David Brizel and Paolo Rovea and Athanassios Argiris and Nagy, {Zolt{\'a}n Tak{\'a}csi} and Lee, {Ju Whei} and Catherine Fortpied and Jonathan Harris and Jean Bourhis and Anne Aup{\'e}rin and Pierre Blanchard and Pignon, {Jean Pierre} and J. Overgaard and {MACH-NC Collaborative Group}",
note = "Publisher Copyright: {\textcopyright} 2021 Elsevier B.V. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = mar,
doi = "10.1016/j.radonc.2021.01.013",
language = "English",
volume = "156",
pages = "281--293",
journal = "Radiotherapy & Oncology",
issn = "0167-8140",
publisher = "Elsevier Ireland Ltd.",

}

RIS

TY - JOUR

T1 - Meta-analysis of chemotherapy in head and neck cancer (MACH-NC)

T2 - An update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group

AU - Lacas, Benjamin

AU - Carmel, Alexandra

AU - Landais, Cécile

AU - Wong, Stuart J.

AU - Licitra, Lisa

AU - Tobias, Jeffrey S.

AU - Burtness, Barbara

AU - Ghi, Maria Grazia

AU - Cohen, Ezra E.W.

AU - Grau, Cai

AU - Wolf, Gregory

AU - Hitt, Ricardo

AU - Corvò, Renzo

AU - Budach, Volker

AU - Kumar, Shaleen

AU - Laskar, Sarbani Ghosh

AU - Mazeron, Jean Jacques

AU - Zhong, Lai Ping

AU - Dobrowsky, Werner

AU - Ghadjar, Pirus

AU - Fallai, Carlo

AU - Zakotnik, Branko

AU - Sharma, Atul

AU - Bensadoun, René Jean

AU - Ruo Redda, Maria Grazia

AU - Racadot, Séverine

AU - Fountzilas, George

AU - Brizel, David

AU - Rovea, Paolo

AU - Argiris, Athanassios

AU - Nagy, Zoltán Takácsi

AU - Lee, Ju Whei

AU - Fortpied, Catherine

AU - Harris, Jonathan

AU - Bourhis, Jean

AU - Aupérin, Anne

AU - Blanchard, Pierre

AU - Pignon, Jean Pierre

AU - Overgaard, J.

AU - MACH-NC Collaborative Group

N1 - Publisher Copyright: © 2021 Elsevier B.V. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/3

Y1 - 2021/3

N2 - Background and purpose: The Meta-Analysis of Chemotherapy in squamous cell Head and Neck Cancer (MACH-NC) demonstrated that concomitant chemotherapy (CT) improved overall survival (OS) in patients without distant metastasis. We report the updated results. Materials and methods: Published or unpublished randomized trials including patients with non-metastatic carcinoma randomized between 1965 and 2016 and comparing curative loco-regional treatment (LRT) to LRT + CT or adding another timing of CT to LRT + CT (main question), or comparing induction CT + radiotherapy to radiotherapy + concomitant (or alternating) CT (secondary question) were eligible. Individual patient data were collected and combined using a fixed-effect model. OS was the main endpoint. Results: For the main question, 101 trials (18951 patients, median follow-up of 6.5 years) were analyzed. For both questions, there were 16 new (2767 patients) and 11 updated trials. Around 90% of the patients had stage III or IV disease. Interaction between treatment effect on OS and the timing of CT was significant (p < 0.0001), the benefit being limited to concomitant CT (HR: 0.83, 95%CI [0.79; 0.86]; 5(10)-year absolute benefit of 6.5% (3.6%)). Efficacy decreased as patients age increased (p_trend = 0.03). OS was not increased by the addition of induction (HR = 0.96 [0.90; 1.01]) or adjuvant CT (1.02 [0.92; 1.13]). Efficacy of induction CT decreased with poorer performance status (p_trend = 0.03). For the secondary question, eight trials (1214 patients) confirmed the superiority of concomitant CT on OS (HR = 0.84 [0.74; 0.95], p = 0.005). Conclusion: The update of MACH-NC confirms the benefit and superiority of the addition of concomitant CT for non-metastatic head and neck cancer.

AB - Background and purpose: The Meta-Analysis of Chemotherapy in squamous cell Head and Neck Cancer (MACH-NC) demonstrated that concomitant chemotherapy (CT) improved overall survival (OS) in patients without distant metastasis. We report the updated results. Materials and methods: Published or unpublished randomized trials including patients with non-metastatic carcinoma randomized between 1965 and 2016 and comparing curative loco-regional treatment (LRT) to LRT + CT or adding another timing of CT to LRT + CT (main question), or comparing induction CT + radiotherapy to radiotherapy + concomitant (or alternating) CT (secondary question) were eligible. Individual patient data were collected and combined using a fixed-effect model. OS was the main endpoint. Results: For the main question, 101 trials (18951 patients, median follow-up of 6.5 years) were analyzed. For both questions, there were 16 new (2767 patients) and 11 updated trials. Around 90% of the patients had stage III or IV disease. Interaction between treatment effect on OS and the timing of CT was significant (p < 0.0001), the benefit being limited to concomitant CT (HR: 0.83, 95%CI [0.79; 0.86]; 5(10)-year absolute benefit of 6.5% (3.6%)). Efficacy decreased as patients age increased (p_trend = 0.03). OS was not increased by the addition of induction (HR = 0.96 [0.90; 1.01]) or adjuvant CT (1.02 [0.92; 1.13]). Efficacy of induction CT decreased with poorer performance status (p_trend = 0.03). For the secondary question, eight trials (1214 patients) confirmed the superiority of concomitant CT on OS (HR = 0.84 [0.74; 0.95], p = 0.005). Conclusion: The update of MACH-NC confirms the benefit and superiority of the addition of concomitant CT for non-metastatic head and neck cancer.

KW - Chemotherapy

KW - Head and Neck Cancer

KW - Individual Patient Data

KW - Meta-analysis

KW - Radiotherapy

KW - Randomised Clinical Trials

UR - http://www.scopus.com/inward/record.url?scp=85102363781&partnerID=8YFLogxK

U2 - 10.1016/j.radonc.2021.01.013

DO - 10.1016/j.radonc.2021.01.013

M3 - Journal article

C2 - 33515668

AN - SCOPUS:85102363781

VL - 156

SP - 281

EP - 293

JO - Radiotherapy & Oncology

JF - Radiotherapy & Oncology

SN - 0167-8140

ER -