TY - JOUR

T1 - Memory and Executive Functions in Patients with Obsessive-Compulsive Disorder

AU - Vandborg, Sanne Kjaer

AU - Hartmann, Tue Borst

AU - Bennedsen, Birgit Egedal

AU - Pedersen, Anders Degn

AU - Thomsen, Per Hove

PY - 2014

Y1 - 2014

N2 - Objective:We investigated whether patients with obsessive-compulsive disorder have poorer memory and executive functions than healthy controls.Background:The relatively inconsistent previous findings on this question reflect a lack of well-matched control groups, the inclusion of patients with comorbidity, and the use of noncomparable neuropsychological tests to assess memory and executive functions.Methods:We used well-accepted neuropsychological tests of memory and executive functions to assess 42 patients who had obsessive-compulsive disorder without comorbidity, and 42 healthy controls. We matched the patients and controls pairwise by sex, age, and years of education.Results:The patients performed significantly worse than the controls on the Rey Complex Figure Test, which assesses visuospatial memory and organizational skills. This group difference remained after we controlled for age, education, intelligence, and severity of depressive symptoms.Conclusions:The findings indicate that patients with obsessive-compulsive disorder may have impaired visuospatial memory and organizational skills, and these impairments should be considered in treatment.Trial Registration:ClinicalTrials.gov NCT00792038.

AB - Objective:We investigated whether patients with obsessive-compulsive disorder have poorer memory and executive functions than healthy controls.Background:The relatively inconsistent previous findings on this question reflect a lack of well-matched control groups, the inclusion of patients with comorbidity, and the use of noncomparable neuropsychological tests to assess memory and executive functions.Methods:We used well-accepted neuropsychological tests of memory and executive functions to assess 42 patients who had obsessive-compulsive disorder without comorbidity, and 42 healthy controls. We matched the patients and controls pairwise by sex, age, and years of education.Results:The patients performed significantly worse than the controls on the Rey Complex Figure Test, which assesses visuospatial memory and organizational skills. This group difference remained after we controlled for age, education, intelligence, and severity of depressive symptoms.Conclusions:The findings indicate that patients with obsessive-compulsive disorder may have impaired visuospatial memory and organizational skills, and these impairments should be considered in treatment.Trial Registration:ClinicalTrials.gov NCT00792038.

KW - memory

KW - obsessive-compulsive disorder

KW - neuropsychological tests

KW - executive function

KW - cognition

KW - FRONTAL-LOBE DYSFUNCTION

KW - NEUROPSYCHOLOGICAL PERFORMANCE

KW - NONVERBAL MEMORY

KW - ORGANIZATIONAL STRATEGIES

KW - COGNITIVE REMEDIATION

KW - WORKING-MEMORY

KW - UNIPOLAR DEPRESSION

KW - CLINICAL-VARIABLES

KW - DSM-IV

KW - DEFICITS

KW - OCD

KW - Cognition

KW - executive function

KW - memory

U2 - 10.1097/WNN.0000000000000021

DO - 10.1097/WNN.0000000000000021

M3 - Journal article

C2 - 24674961

VL - 27

SP - 8

EP - 16

JO - Cognitive and Behavioral Neurology

JF - Cognitive and Behavioral Neurology

SN - 1543-3633

IS - 1

ER -