Membranous septum morphology and risk of conduction abnormalities after transcatheter aortic valve implantation

Troels Højsgaard Jørgensen; Nicolaj Hansson; Ole De Backer; Gintautas Bieliauskas; Christian Juhl Terkelsen; Xi Wang; Jesper Møller Jensen; Evald Høj Christiansen; Nicolo Piazza; Jesper Hastrup Svendsen; Bjarne Linde Nørgaard; Lars Søndergaard

doi:10.4244/EIJ-D-21-00363

Membranous septum morphology and risk of conduction abnormalities after transcatheter aortic valve implantation

Troels Højsgaard Jørgensen, Nicolaj Hansson, Ole De Backer, Gintautas Bieliauskas, Christian Juhl Terkelsen, Xi Wang, Jesper Møller Jensen, Evald Høj Christiansen, Nicolo Piazza, Jesper Hastrup Svendsen, Bjarne Linde Nørgaard, Lars Søndergaard

Institut for Klinisk Medicin - Hjertesygdomme

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Abstract

BACKGROUND: There are limited data on the association of membranous septum (MS) morphology and transcatheter heart valve (THV) implantation depth, and the development of new conduction abnormalities (CA) after transcatheter aortic valve implantation (TAVI). AIMS: The aim of this study was to describe the morphology of the MS and predict the risk of new CA after TAVI based on the MS morphology and THV implantation depth. METHODS: Based on preprocedural CT scans, the MS depth was measured for every 25% of the entire MS width in 272 TAVI patients without preprocedural bundle branch block (BBB) or pacemaker. Post-procedural CT scans for THV implantation depth assessment were available in 130 of these patients. RESULTS: The MS depth was a median of 2.5 mm (IQR 1.4-3.8) deeper at the posterior edge when compared to the anterior edge of the MS. New CA developed in 7.1% of patients in whom the THV did not cross the lower MS border at its anterior edge (3.6% with new BBB and high degree CA, respectively), in 18.8% of patients (15.6% with new BBB and 3.1% with new high-degree CA) where the THV overlapped the lower MS border by <2.5 mm and in 47.1% of patients (24.3% with new BBB and 22.9% with new high-degree CA) with THV overlap of the lower MS border by ≥2.5 mm. CONCLUSIONS: The difference of the MS depth and THV implantation depth measured at the anterior edge of the MS predicted new CA after TAVI.

Originalsprog	Engelsk
Tidsskrift	EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
Vol/bind	17
Nummer	13
Sider (fra-til)	1061-1069
Antal sider	9
ISSN	1774-024X
DOI	https://doi.org/10.4244/EIJ-D-21-00363
Status	Udgivet - jan. 2022

Adgang til dokumentet

10.4244/EIJ-D-21-00363

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9725046/pdf/EIJ-D-21-00363_Jorgensen.pdf

Citationsformater

Jørgensen, T. H., Hansson, N., De Backer, O., Bieliauskas, G., Terkelsen, C. J., Wang, X., Jensen, J. M., Christiansen, E. H., Piazza, N., Svendsen, J. H., Nørgaard, B. L., & Søndergaard, L. (2022). Membranous septum morphology and risk of conduction abnormalities after transcatheter aortic valve implantation. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 17(13), 1061-1069. https://doi.org/10.4244/EIJ-D-21-00363

Jørgensen, Troels Højsgaard ; Hansson, Nicolaj ; De Backer, Ole et al. / Membranous septum morphology and risk of conduction abnormalities after transcatheter aortic valve implantation. I: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology. 2022 ; Bind 17, Nr. 13. s. 1061-1069.

@article{e789276a3f5347d0bebf6d67d0012969,

title = "Membranous septum morphology and risk of conduction abnormalities after transcatheter aortic valve implantation",

abstract = "BACKGROUND: There are limited data on the association of membranous septum (MS) morphology and transcatheter heart valve (THV) implantation depth, and the development of new conduction abnormalities (CA) after transcatheter aortic valve implantation (TAVI). AIMS: The aim of this study was to describe the morphology of the MS and predict the risk of new CA after TAVI based on the MS morphology and THV implantation depth. METHODS: Based on preprocedural CT scans, the MS depth was measured for every 25% of the entire MS width in 272 TAVI patients without preprocedural bundle branch block (BBB) or pacemaker. Post-procedural CT scans for THV implantation depth assessment were available in 130 of these patients. RESULTS: The MS depth was a median of 2.5 mm (IQR 1.4-3.8) deeper at the posterior edge when compared to the anterior edge of the MS. New CA developed in 7.1% of patients in whom the THV did not cross the lower MS border at its anterior edge (3.6% with new BBB and high degree CA, respectively), in 18.8% of patients (15.6% with new BBB and 3.1% with new high-degree CA) where the THV overlapped the lower MS border by <2.5 mm and in 47.1% of patients (24.3% with new BBB and 22.9% with new high-degree CA) with THV overlap of the lower MS border by ≥2.5 mm. CONCLUSIONS: The difference of the MS depth and THV implantation depth measured at the anterior edge of the MS predicted new CA after TAVI.",

keywords = "Aortic Valve Stenosis/diagnostic imaging, Aortic Valve/diagnostic imaging, Bundle-Branch Block/therapy, Heart Valve Prosthesis, Humans, Pacemaker, Artificial, Retrospective Studies, Transcatheter Aortic Valve Replacement/adverse effects, Treatment Outcome, Left bundle branch, TAVI, Atrioventricular block",

author = "J{\o}rgensen, {Troels H{\o}jsgaard} and Nicolaj Hansson and {De Backer}, Ole and Gintautas Bieliauskas and Terkelsen, {Christian Juhl} and Xi Wang and Jensen, {Jesper M{\o}ller} and Christiansen, {Evald H{\o}j} and Nicolo Piazza and Svendsen, {Jesper Hastrup} and N{\o}rgaard, {Bjarne Linde} and Lars S{\o}ndergaard",

year = "2022",

month = jan,

doi = "10.4244/EIJ-D-21-00363",

language = "English",

volume = "17",

pages = "1061--1069",

journal = "EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology",

issn = "1774-024X",

publisher = "Europa Digital & Publishing",

number = "13",

}

Jørgensen, TH, Hansson, N, De Backer, O, Bieliauskas, G, Terkelsen, CJ, Wang, X, Jensen, JM, Christiansen, EH, Piazza, N, Svendsen, JH, Nørgaard, BL & Søndergaard, L 2022, 'Membranous septum morphology and risk of conduction abnormalities after transcatheter aortic valve implantation', EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, bind 17, nr. 13, s. 1061-1069. https://doi.org/10.4244/EIJ-D-21-00363

Membranous septum morphology and risk of conduction abnormalities after transcatheter aortic valve implantation. / Jørgensen, Troels Højsgaard; Hansson, Nicolaj; De Backer, Ole et al.
I: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Bind 17, Nr. 13, 01.2022, s. 1061-1069.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Membranous septum morphology and risk of conduction abnormalities after transcatheter aortic valve implantation

AU - Jørgensen, Troels Højsgaard

AU - Hansson, Nicolaj

AU - De Backer, Ole

AU - Bieliauskas, Gintautas

AU - Terkelsen, Christian Juhl

AU - Wang, Xi

AU - Jensen, Jesper Møller

AU - Christiansen, Evald Høj

AU - Piazza, Nicolo

AU - Svendsen, Jesper Hastrup

AU - Nørgaard, Bjarne Linde

AU - Søndergaard, Lars

PY - 2022/1

Y1 - 2022/1

N2 - BACKGROUND: There are limited data on the association of membranous septum (MS) morphology and transcatheter heart valve (THV) implantation depth, and the development of new conduction abnormalities (CA) after transcatheter aortic valve implantation (TAVI). AIMS: The aim of this study was to describe the morphology of the MS and predict the risk of new CA after TAVI based on the MS morphology and THV implantation depth. METHODS: Based on preprocedural CT scans, the MS depth was measured for every 25% of the entire MS width in 272 TAVI patients without preprocedural bundle branch block (BBB) or pacemaker. Post-procedural CT scans for THV implantation depth assessment were available in 130 of these patients. RESULTS: The MS depth was a median of 2.5 mm (IQR 1.4-3.8) deeper at the posterior edge when compared to the anterior edge of the MS. New CA developed in 7.1% of patients in whom the THV did not cross the lower MS border at its anterior edge (3.6% with new BBB and high degree CA, respectively), in 18.8% of patients (15.6% with new BBB and 3.1% with new high-degree CA) where the THV overlapped the lower MS border by <2.5 mm and in 47.1% of patients (24.3% with new BBB and 22.9% with new high-degree CA) with THV overlap of the lower MS border by ≥2.5 mm. CONCLUSIONS: The difference of the MS depth and THV implantation depth measured at the anterior edge of the MS predicted new CA after TAVI.

AB - BACKGROUND: There are limited data on the association of membranous septum (MS) morphology and transcatheter heart valve (THV) implantation depth, and the development of new conduction abnormalities (CA) after transcatheter aortic valve implantation (TAVI). AIMS: The aim of this study was to describe the morphology of the MS and predict the risk of new CA after TAVI based on the MS morphology and THV implantation depth. METHODS: Based on preprocedural CT scans, the MS depth was measured for every 25% of the entire MS width in 272 TAVI patients without preprocedural bundle branch block (BBB) or pacemaker. Post-procedural CT scans for THV implantation depth assessment were available in 130 of these patients. RESULTS: The MS depth was a median of 2.5 mm (IQR 1.4-3.8) deeper at the posterior edge when compared to the anterior edge of the MS. New CA developed in 7.1% of patients in whom the THV did not cross the lower MS border at its anterior edge (3.6% with new BBB and high degree CA, respectively), in 18.8% of patients (15.6% with new BBB and 3.1% with new high-degree CA) where the THV overlapped the lower MS border by <2.5 mm and in 47.1% of patients (24.3% with new BBB and 22.9% with new high-degree CA) with THV overlap of the lower MS border by ≥2.5 mm. CONCLUSIONS: The difference of the MS depth and THV implantation depth measured at the anterior edge of the MS predicted new CA after TAVI.

KW - Aortic Valve Stenosis/diagnostic imaging

KW - Aortic Valve/diagnostic imaging

KW - Bundle-Branch Block/therapy

KW - Heart Valve Prosthesis

KW - Humans

KW - Pacemaker, Artificial

KW - Retrospective Studies

KW - Transcatheter Aortic Valve Replacement/adverse effects

KW - Treatment Outcome

KW - Left bundle branch

KW - TAVI

KW - Atrioventricular block

U2 - 10.4244/EIJ-D-21-00363

DO - 10.4244/EIJ-D-21-00363

M3 - Journal article

C2 - 34338638

SN - 1774-024X

VL - 17

SP - 1061

EP - 1069

JO - EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

JF - EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

IS - 13

ER -

Jørgensen TH, Hansson N, De Backer O, Bieliauskas G, Terkelsen CJ, Wang X et al. Membranous septum morphology and risk of conduction abnormalities after transcatheter aortic valve implantation. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology. 2022 jan.;17(13):1061-1069. Epub 2021 aug. 3. doi: 10.4244/EIJ-D-21-00363

Membranous septum morphology and risk of conduction abnormalities after transcatheter aortic valve implantation

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater