Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
Mechanisms of antidepressant action : an integrated dopaminergic perspective. / Porcelli, S; Drago, A; Fabbri, C et al.
I: Progress in Neuro-Psychopharmacology & Biological Psychiatry, Bind 35, Nr. 7, 15.08.2011, s. 1532-43.Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Mechanisms of antidepressant action
T2 - an integrated dopaminergic perspective
AU - Porcelli, S
AU - Drago, A
AU - Fabbri, C
AU - Serretti, A
N1 - Copyright © 2011 Elsevier Inc. All rights reserved.
PY - 2011/8/15
Y1 - 2011/8/15
N2 - The molecular mechanisms that cause and maintain the major depressive disorder (MDD) are currently unknown. Consistently, antidepressant treatments are characterized by insufficient success rates. This causes high social costs and severe personal sufferings. In the present review we analyze some of the paradigms that are used to explain MDD, particularly from the perspective of the dopaminergic (DA) system. DA has been more classically associated with psychosis and substance abuse disorders, even though a role of DA in MDD has been proposed as well and some antidepressants with DA profile exist. In the present work, we review some of the molecular mechanisms that underpin MDD from the perspective of the dopaminergic system, in the hope of unifying some of the major theories of MDD - the monoaminergic, inflammatory, epigenetics, neurotrophin and anti-apoptotic theories. Several shared components of these theories are highlighted, partially accounted by the functions of the DA system (see supplementary video).
AB - The molecular mechanisms that cause and maintain the major depressive disorder (MDD) are currently unknown. Consistently, antidepressant treatments are characterized by insufficient success rates. This causes high social costs and severe personal sufferings. In the present review we analyze some of the paradigms that are used to explain MDD, particularly from the perspective of the dopaminergic (DA) system. DA has been more classically associated with psychosis and substance abuse disorders, even though a role of DA in MDD has been proposed as well and some antidepressants with DA profile exist. In the present work, we review some of the molecular mechanisms that underpin MDD from the perspective of the dopaminergic system, in the hope of unifying some of the major theories of MDD - the monoaminergic, inflammatory, epigenetics, neurotrophin and anti-apoptotic theories. Several shared components of these theories are highlighted, partially accounted by the functions of the DA system (see supplementary video).
KW - Antidepressive Agents
KW - Biogenic Monoamines
KW - Depressive Disorder, Major
KW - Dopamine
KW - Dopamine Agents
KW - Humans
KW - Inflammation
KW - Nerve Growth Factors
U2 - 10.1016/j.pnpbp.2011.03.005
DO - 10.1016/j.pnpbp.2011.03.005
M3 - Journal article
C2 - 21402119
VL - 35
SP - 1532
EP - 1543
JO - Progress in Neuro-Psychopharmacology & Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology & Biological Psychiatry
SN - 0278-5846
IS - 7
ER -