Mechanical memory based biofabrication of hierarchical elastic cardiac tissue

Zhitong Li; Panna Kovács; Alice Le Friec; Bjarke Nørrehvedde Jensen; Jens Vinge Nygaard; Menglin Chen

doi:10.1088/1758-5090/ad89fd

Mechanical memory based biofabrication of hierarchical elastic cardiac tissue

Zhitong Li
, Panna Kovács
, Alice Le Friec
, Bjarke Nørrehvedde Jensen
, Jens Vinge Nygaard
, Menglin Chen^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

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Abstract

Mimicking the multilayered, anisotropic, elastic structure of cardiac tissues for controlled guidiance of 3D cellular orientation is essential in designing bionic scaffolds for cardiac tissue biofabrication. Here, a hierarchically organized, anisotropic, wavy and conductive polycaprolactone/Au scaffold was created in a facile fashion based on mechanical memory during fabrication. The bionic 3D scaffold shows good biocompatibility, excellent biomimetic mechanical properties that guide myoblast alignment, support the hyperelastic behavior observed in native cardiac muscle tissue, and promote myotube maturation, which holds potential for cardiac muscle engineering and the establishment of anin vitroculture platform for drug screening.

Originalsprog	Engelsk
Artikelnummer	015013
Tidsskrift	Biofabrication
Vol/bind	17
Nummer	1
DOI	https://doi.org/10.1088/1758-5090/ad89fd
Status	Udgivet - 1 jan. 2025

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10.1088/1758-5090/ad89fdLicens: CC BY

Li_2025_Biofabrication_17_015013Forlagets udgivne version, 5,94 MBLicens: CC BY

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AU - Li, Zhitong

AU - Kovács, Panna

AU - Friec, Alice Le

AU - Jensen, Bjarke Nørrehvedde

AU - Nygaard, Jens Vinge

AU - Chen, Menglin

PY - 2025/1/1

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N2 - Mimicking the multilayered, anisotropic, elastic structure of cardiac tissues for controlled guidiance of 3D cellular orientation is essential in designing bionic scaffolds for cardiac tissue biofabrication. Here, a hierarchically organized, anisotropic, wavy and conductive polycaprolactone/Au scaffold was created in a facile fashion based on mechanical memory during fabrication. The bionic 3D scaffold shows good biocompatibility, excellent biomimetic mechanical properties that guide myoblast alignment, support the hyperelastic behavior observed in native cardiac muscle tissue, and promote myotube maturation, which holds potential for cardiac muscle engineering and the establishment of anin vitroculture platform for drug screening.

AB - Mimicking the multilayered, anisotropic, elastic structure of cardiac tissues for controlled guidiance of 3D cellular orientation is essential in designing bionic scaffolds for cardiac tissue biofabrication. Here, a hierarchically organized, anisotropic, wavy and conductive polycaprolactone/Au scaffold was created in a facile fashion based on mechanical memory during fabrication. The bionic 3D scaffold shows good biocompatibility, excellent biomimetic mechanical properties that guide myoblast alignment, support the hyperelastic behavior observed in native cardiac muscle tissue, and promote myotube maturation, which holds potential for cardiac muscle engineering and the establishment of anin vitroculture platform for drug screening.

KW - 3D cellular alignment

KW - anisotropy

KW - cardiac tissue engineering

KW - mechanical memory

UR - https://www.scopus.com/pages/publications/85208516027

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VL - 17

JO - Biofabrication

JF - Biofabrication

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ER -

Mechanical memory based biofabrication of hierarchical elastic cardiac tissue

Abstract

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