Mebendazole treatment persistently alters the size profile and morphology of Trichuris trichiura eggs

Peter Nejsum; Kasper Lind Andersen; Sidsel Dahl Andersen; Stig Milan Thamsborg; Ana Merino Tejedor

doi:10.1016/j.actatropica.2020.105347

Mebendazole treatment persistently alters the size profile and morphology of Trichuris trichiura eggs

Peter Nejsum, Kasper Lind Andersen, Sidsel Dahl Andersen, Stig Milan Thamsborg, Ana Merino Tejedor

Institut for Klinisk Medicin - Infektionssygdomme

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Abstract

The soil transmitted whipworm, Trichuris trichiura affects about half a billion people globally. Diagnosis is based on identification of characteristic lemon-shaped eggs in stool samples. Occasionally large Trichuris eggs have been reported and have been ascribed to variation within T. trichiura or zoonotic infection with T. vulpis from dogs. We observed that the egg size profile changed markedly after anthelmintic treatment, and remained so, in a human individual self-infected with T. trichiura. The large eggs were detected with two standard diagnostic methods, Kato-Katz thick smear and salt-flotation (McMaster) method. It is therefore important to bear in mind that the morphology of parasite eggs may vary, e.g. in response to previous drug treatment. Large Trichuris eggs in human stool samples should not be diagnosed as T. vulpis infection without confirmation by other means.

Originalsprog	Engelsk
Artikelnummer	105347
Tidsskrift	Acta Tropica
Vol/bind	204
Antal sider	4
ISSN	0001-706X
DOI	https://doi.org/10.1016/j.actatropica.2020.105347
Status	Udgivet - apr. 2020

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title = "Mebendazole treatment persistently alters the size profile and morphology of Trichuris trichiura eggs",

abstract = "The soil transmitted whipworm, Trichuris trichiura affects about half a billion people globally. Diagnosis is based on identification of characteristic lemon-shaped eggs in stool samples. Occasionally large Trichuris eggs have been reported and have been ascribed to variation within T. trichiura or zoonotic infection with T. vulpis from dogs. We observed that the egg size profile changed markedly after anthelmintic treatment, and remained so, in a human individual self-infected with T. trichiura. The large eggs were detected with two standard diagnostic methods, Kato-Katz thick smear and salt-flotation (McMaster) method. It is therefore important to bear in mind that the morphology of parasite eggs may vary, e.g. in response to previous drug treatment. Large Trichuris eggs in human stool samples should not be diagnosed as T. vulpis infection without confirmation by other means.",

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author = "Peter Nejsum and Andersen, {Kasper Lind} and Andersen, {Sidsel Dahl} and Thamsborg, {Stig Milan} and Tejedor, {Ana Merino}",

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AU - Nejsum, Peter

AU - Andersen, Kasper Lind

AU - Andersen, Sidsel Dahl

AU - Thamsborg, Stig Milan

AU - Tejedor, Ana Merino

PY - 2020/4

Y1 - 2020/4

N2 - The soil transmitted whipworm, Trichuris trichiura affects about half a billion people globally. Diagnosis is based on identification of characteristic lemon-shaped eggs in stool samples. Occasionally large Trichuris eggs have been reported and have been ascribed to variation within T. trichiura or zoonotic infection with T. vulpis from dogs. We observed that the egg size profile changed markedly after anthelmintic treatment, and remained so, in a human individual self-infected with T. trichiura. The large eggs were detected with two standard diagnostic methods, Kato-Katz thick smear and salt-flotation (McMaster) method. It is therefore important to bear in mind that the morphology of parasite eggs may vary, e.g. in response to previous drug treatment. Large Trichuris eggs in human stool samples should not be diagnosed as T. vulpis infection without confirmation by other means.

AB - The soil transmitted whipworm, Trichuris trichiura affects about half a billion people globally. Diagnosis is based on identification of characteristic lemon-shaped eggs in stool samples. Occasionally large Trichuris eggs have been reported and have been ascribed to variation within T. trichiura or zoonotic infection with T. vulpis from dogs. We observed that the egg size profile changed markedly after anthelmintic treatment, and remained so, in a human individual self-infected with T. trichiura. The large eggs were detected with two standard diagnostic methods, Kato-Katz thick smear and salt-flotation (McMaster) method. It is therefore important to bear in mind that the morphology of parasite eggs may vary, e.g. in response to previous drug treatment. Large Trichuris eggs in human stool samples should not be diagnosed as T. vulpis infection without confirmation by other means.

KW - Anthelmintic treatment

KW - Diagnostics

KW - Egg size

KW - Kato Katz

KW - McMaster

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JO - Acta Tropica

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Mebendazole treatment persistently alters the size profile and morphology of Trichuris trichiura eggs

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