TY - JOUR
T1 - Measurement of health-related and oral health-related quality of life among individuals with nonsyndromic orofacial clefts
T2 - A systematic review and meta-analysis
AU - De Queiroz Herkrath, Ana Paula Corrěa
AU - Herkrath, Fernando José
AU - Rebelo, Maria Augusta Bessa
AU - Vettore, Mario Vianna
N1 - Publisher Copyright:
© Copyright 2015 American Cleft Palate-Craniofacial Association.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Objective: To compare health-related quality of life and oral health-related quality of life between nonsyndromic individuals with and without cleft lip and/or cleft palate and to identify the most affected quality of life dimensions in individuals with cleft lip and/or palate. Design: Systematic review and meta-analysis were conducted. Of the 314 identified citations, 23 articles were submitted to quality assessment. Data from nine studies on health-related quality of life and six on oral health-related quality of life were extracted for meta-analysis. Main Outcome Measures: Pooled mean differences of health-related quality of life between adults with and without cleft lip and/or palate, pooled means of health-related quality of life dimensions of children and adults with cleft lip and/or palate and oral health-related quality of life dimensions of children and adolescents with cleft lip and/or palate with a 95% confidence interval were calculated. Results: Quality assessment revealed methodological differences between studies. Lack of subgroup stratification and absence of control for confounders were the main limitations. Heterogeneity was detected on the comparison of oral health-related quality of life and healthrelated quality of life between children with and without cleft lip and/or palate, and oral health- related quality of life between adolescents with and without cleft lip and/or palate. A randomeffect model showed a significant difference on health-related quality of life between adults with and without cleft lip and/or palate (mean difference=0.10; 95% confidence interval, 0.16 to 0.05). Psychological health (mean, 78.9; 95% confidence interval, 70.1 to 87.7) and vitality (mean, 68.1; 95% confidence interval, 48.0 to 88.1) were the most affected health-related quality of life dimensions in children and adults with cleft lip and/or palate, respectively. Means of healthrelated quality of life dimensions in children and adults with cleft lip and/or palate and oral health-related quality of life in children and adolescents with cleft lip and/or palate varied yet did not differ in indirect comparisons. Conclusion: The presence of cleft lip and/or palate negatively affected the health-related quality of life of adults, mainly on psychosocial dimensions.
AB - Objective: To compare health-related quality of life and oral health-related quality of life between nonsyndromic individuals with and without cleft lip and/or cleft palate and to identify the most affected quality of life dimensions in individuals with cleft lip and/or palate. Design: Systematic review and meta-analysis were conducted. Of the 314 identified citations, 23 articles were submitted to quality assessment. Data from nine studies on health-related quality of life and six on oral health-related quality of life were extracted for meta-analysis. Main Outcome Measures: Pooled mean differences of health-related quality of life between adults with and without cleft lip and/or palate, pooled means of health-related quality of life dimensions of children and adults with cleft lip and/or palate and oral health-related quality of life dimensions of children and adolescents with cleft lip and/or palate with a 95% confidence interval were calculated. Results: Quality assessment revealed methodological differences between studies. Lack of subgroup stratification and absence of control for confounders were the main limitations. Heterogeneity was detected on the comparison of oral health-related quality of life and healthrelated quality of life between children with and without cleft lip and/or palate, and oral health- related quality of life between adolescents with and without cleft lip and/or palate. A randomeffect model showed a significant difference on health-related quality of life between adults with and without cleft lip and/or palate (mean difference=0.10; 95% confidence interval, 0.16 to 0.05). Psychological health (mean, 78.9; 95% confidence interval, 70.1 to 87.7) and vitality (mean, 68.1; 95% confidence interval, 48.0 to 88.1) were the most affected health-related quality of life dimensions in children and adults with cleft lip and/or palate, respectively. Means of healthrelated quality of life dimensions in children and adults with cleft lip and/or palate and oral health-related quality of life in children and adolescents with cleft lip and/or palate varied yet did not differ in indirect comparisons. Conclusion: The presence of cleft lip and/or palate negatively affected the health-related quality of life of adults, mainly on psychosocial dimensions.
KW - Cleft lip
KW - Cleft palate
KW - Meta-analysis
KW - Quality of life
UR - http://www.scopus.com/inward/record.url?scp=84923831199&partnerID=8YFLogxK
U2 - 10.1597/13-104
DO - 10.1597/13-104
M3 - Review
C2 - 24805870
AN - SCOPUS:84923831199
SN - 1055-6656
VL - 52
SP - 157
EP - 172
JO - Cleft Palate-Craniofacial Journal
JF - Cleft Palate-Craniofacial Journal
IS - 2
ER -