MBL1 genotypes in wild boar populations from Sweden, Austria, the Czech Republic, and Japan

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  • Ingrid-Maria Bergman, Sverige
  • Kerstin Sandholm, Linnaeus University, School of Natural Sciences, Sverige
  • Kristina Ekdahl, Linnaeus University, School of Natural Sciences, Sverige
  • Naohiko Okumura, Institute of Society for Techno-innovation of Agriculture, Forestry and Fisheries, Japan
  • Hirohide Uenishi, National Institute of Agrobiological Sciences, Agrogenomics Research Center, Japan
  • Bernt Guldbrandtsen
  • Sabine Essler, Universit of Veterinary Medicine Vienna, Department of Pathobiology, Østrig
  • Ales Knoll, Mendel University, Department of Animal Physiology, Tjekkiet
  • Peter M. H. Heegaard, Division of Veterinary Diagnostics and Research, Danmark
  • I Edfors, Sverige
  • Helle Risdahl Juul-Madsen, Danmark
The single nucleotide polymorphism (SNP) G949T in the mannose-binding lectin ( MBL ) 1 gene has been associated with low MBL-A concentration in serum and detected at different frequencies in various European pig populations. However, the origin of this SNP is not known. Part of the MBL1 gene was sequenced in 12 wild boar/Large White crossbred pigs from the second backcross (BC 2) generation in a family material originating from two wild boar x Large White intercrosses. Also, MBL-A serum concentration was measured in the entire BC 2 generation (n = 45). Furthermore, the genotypes of 68 wild boars from Sweden, Austria, the Czech Republic, and Japan were determined in regard to five previously described SNPs in MBL1 . The T allele of G949T was present among the BC 2 animals. MBL-A serum concentration in the BC 2 animals showed a bimodal distribution, with one-third of the animals at levels between 0.7 and 1.6 μg mL−1 and the remaining pigs at levels around 13 μg mL−1. There was a co-variation between the presence of the T allele and low MBL-A concentration in serum. The genotyping of the wild boars revealed differences between populations. The T allele of G949T was not detected in the Austrian and Japanese samples and is thus unlikely to be an original feature of wild boars. In contrast, it was present at high frequency (0.35) among the Swedish wild boars, probably representing a founder effect. Five MBL1 haplotypes were resolved. Only two of these were present among the Japanese wild boars compared to four in each of the European populations. This difference may reflect differences in selection pressure and population history.
OriginalsprogEngelsk
TidsskriftInternational Journal of Immunogenetics (Print Edition)
Vol/bind40
Nummer2
Sider (fra-til)131-139
Antal sider9
ISSN1744-3121
DOI
StatusUdgivet - apr. 2013

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