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Maternal thyroid disease and adiposity in mother and child

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Standard

Maternal thyroid disease and adiposity in mother and child. / Andersen, Stine Linding; Andersen, Stig; Liew, Zeyan; Vestergaard, Peter; Lundbye-Christensen, Søren; Sørensen, Thorkild I A; Olsen, Jørn.

I: Clinical Endocrinology, Bind 94, Nr. 3, 03.2021.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Andersen, SL, Andersen, S, Liew, Z, Vestergaard, P, Lundbye-Christensen, S, Sørensen, TIA & Olsen, J 2021, 'Maternal thyroid disease and adiposity in mother and child', Clinical Endocrinology, bind 94, nr. 3. https://doi.org/10.1111/cen.14314

APA

Andersen, S. L., Andersen, S., Liew, Z., Vestergaard, P., Lundbye-Christensen, S., Sørensen, T. I. A., & Olsen, J. (2021). Maternal thyroid disease and adiposity in mother and child. Clinical Endocrinology, 94(3). https://doi.org/10.1111/cen.14314

CBE

Andersen SL, Andersen S, Liew Z, Vestergaard P, Lundbye-Christensen S, Sørensen TIA, Olsen J. 2021. Maternal thyroid disease and adiposity in mother and child. Clinical Endocrinology. 94(3). https://doi.org/10.1111/cen.14314

MLA

Vancouver

Andersen SL, Andersen S, Liew Z, Vestergaard P, Lundbye-Christensen S, Sørensen TIA o.a. Maternal thyroid disease and adiposity in mother and child. Clinical Endocrinology. 2021 mar;94(3). https://doi.org/10.1111/cen.14314

Author

Andersen, Stine Linding ; Andersen, Stig ; Liew, Zeyan ; Vestergaard, Peter ; Lundbye-Christensen, Søren ; Sørensen, Thorkild I A ; Olsen, Jørn. / Maternal thyroid disease and adiposity in mother and child. I: Clinical Endocrinology. 2021 ; Bind 94, Nr. 3.

Bibtex

@article{e20b090e9b594ceb87c3dcae9e4248ac,
title = "Maternal thyroid disease and adiposity in mother and child",
abstract = "OBJECTIVE: Thyroid hormones are crucial developmental factors, and thyroid disease in pregnant women is a concern. Overweight and obesity are also important health concerns, and we hypothesized that in utero exposure to maternal thyroid disease could programme the foetus to development of adiposity.DESIGN: Cohort and case-cohort studies.PARTICIPANTS: Pregnant women from the Danish National Birth Cohort and their 7-year-old children.MEASUREMENTS: Maternal thyroid disease (hyperthyroidism and hypothyroidism) was assessed from registrations of diagnoses and treatment (n = 71 706) or from the measurement of thyroid-stimulating hormone (TSH) in a stored blood sample from the early pregnancy (n = 7624). Maternal prepregnancy body mass index (BMI) and child BMI at 7 years of age were used to define overweight and obesity, and associations were evaluated using regression models adjusting for potential confounders.RESULTS: No association was found between maternal thyroid disease in pregnancy and child overweight (hyperthyroidism: adjusted risk ratio (aRR): 1.02 (95% confidence interval (CI): 0.58-1.82); hypothyroidism: 1.31 (0.86-1.97)) or obesity (hyperthyroidism: 0.96 (0.53-1.75); hypothyroidism: 1.25 (0.76-2.05)). On the other hand, pregnant women with hypothyroidism in early pregnancy had a higher risk of being overweight (aRR: 1.20 (95% CI: 1.03; 1.41)) and obese (1.45 (1.07; 1.96)), whereas women with hyperthyroidism had a lower risk of being overweight (0.79 (0.64; 0.98)).CONCLUSIONS: Results provide no evidence that maternal thyroid disease in pregnancy programmes adiposity in the child, but corroborate an association between maternal thyroid disease and adiposity in the mother.",
author = "Andersen, {Stine Linding} and Stig Andersen and Zeyan Liew and Peter Vestergaard and S{\o}ren Lundbye-Christensen and S{\o}rensen, {Thorkild I A} and J{\o}rn Olsen",
note = "{\textcopyright} 2020 John Wiley & Sons Ltd.",
year = "2021",
month = mar,
doi = "10.1111/cen.14314",
language = "English",
volume = "94",
journal = "Clinical Endocrinology",
issn = "0300-0664",
publisher = "Wiley-Blackwell Publishing Ltd.",
number = "3",

}

RIS

TY - JOUR

T1 - Maternal thyroid disease and adiposity in mother and child

AU - Andersen, Stine Linding

AU - Andersen, Stig

AU - Liew, Zeyan

AU - Vestergaard, Peter

AU - Lundbye-Christensen, Søren

AU - Sørensen, Thorkild I A

AU - Olsen, Jørn

N1 - © 2020 John Wiley & Sons Ltd.

PY - 2021/3

Y1 - 2021/3

N2 - OBJECTIVE: Thyroid hormones are crucial developmental factors, and thyroid disease in pregnant women is a concern. Overweight and obesity are also important health concerns, and we hypothesized that in utero exposure to maternal thyroid disease could programme the foetus to development of adiposity.DESIGN: Cohort and case-cohort studies.PARTICIPANTS: Pregnant women from the Danish National Birth Cohort and their 7-year-old children.MEASUREMENTS: Maternal thyroid disease (hyperthyroidism and hypothyroidism) was assessed from registrations of diagnoses and treatment (n = 71 706) or from the measurement of thyroid-stimulating hormone (TSH) in a stored blood sample from the early pregnancy (n = 7624). Maternal prepregnancy body mass index (BMI) and child BMI at 7 years of age were used to define overweight and obesity, and associations were evaluated using regression models adjusting for potential confounders.RESULTS: No association was found between maternal thyroid disease in pregnancy and child overweight (hyperthyroidism: adjusted risk ratio (aRR): 1.02 (95% confidence interval (CI): 0.58-1.82); hypothyroidism: 1.31 (0.86-1.97)) or obesity (hyperthyroidism: 0.96 (0.53-1.75); hypothyroidism: 1.25 (0.76-2.05)). On the other hand, pregnant women with hypothyroidism in early pregnancy had a higher risk of being overweight (aRR: 1.20 (95% CI: 1.03; 1.41)) and obese (1.45 (1.07; 1.96)), whereas women with hyperthyroidism had a lower risk of being overweight (0.79 (0.64; 0.98)).CONCLUSIONS: Results provide no evidence that maternal thyroid disease in pregnancy programmes adiposity in the child, but corroborate an association between maternal thyroid disease and adiposity in the mother.

AB - OBJECTIVE: Thyroid hormones are crucial developmental factors, and thyroid disease in pregnant women is a concern. Overweight and obesity are also important health concerns, and we hypothesized that in utero exposure to maternal thyroid disease could programme the foetus to development of adiposity.DESIGN: Cohort and case-cohort studies.PARTICIPANTS: Pregnant women from the Danish National Birth Cohort and their 7-year-old children.MEASUREMENTS: Maternal thyroid disease (hyperthyroidism and hypothyroidism) was assessed from registrations of diagnoses and treatment (n = 71 706) or from the measurement of thyroid-stimulating hormone (TSH) in a stored blood sample from the early pregnancy (n = 7624). Maternal prepregnancy body mass index (BMI) and child BMI at 7 years of age were used to define overweight and obesity, and associations were evaluated using regression models adjusting for potential confounders.RESULTS: No association was found between maternal thyroid disease in pregnancy and child overweight (hyperthyroidism: adjusted risk ratio (aRR): 1.02 (95% confidence interval (CI): 0.58-1.82); hypothyroidism: 1.31 (0.86-1.97)) or obesity (hyperthyroidism: 0.96 (0.53-1.75); hypothyroidism: 1.25 (0.76-2.05)). On the other hand, pregnant women with hypothyroidism in early pregnancy had a higher risk of being overweight (aRR: 1.20 (95% CI: 1.03; 1.41)) and obese (1.45 (1.07; 1.96)), whereas women with hyperthyroidism had a lower risk of being overweight (0.79 (0.64; 0.98)).CONCLUSIONS: Results provide no evidence that maternal thyroid disease in pregnancy programmes adiposity in the child, but corroborate an association between maternal thyroid disease and adiposity in the mother.

U2 - 10.1111/cen.14314

DO - 10.1111/cen.14314

M3 - Journal article

C2 - 32794201

VL - 94

JO - Clinical Endocrinology

JF - Clinical Endocrinology

SN - 0300-0664

IS - 3

ER -