Maternal serum concentrations of perfluoroalkyl acids in five international birth cohorts

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Maternal serum concentrations of perfluoroalkyl acids in five international birth cohorts. / Bjerregaard-Olesen, Christian; Bossi, Rossana; Liew, Zeyan; Long, Manhai; Bech, Bodil H; Olsen, Jørn; Henriksen, Tine B; Berg, Vivian; Nøst, Therese H; Zhang, Jun J; Bonefeld-Jørgensen, Eva C.

I: International Journal of Hygiene and Environmental Health, Bind 220, Nr. 2 Pt A, 03.2017, s. 86–93.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Bjerregaard-Olesen, C, Bossi, R, Liew, Z, Long, M, Bech, BH, Olsen, J, Henriksen, TB, Berg, V, Nøst, TH, Zhang, JJ & Bonefeld-Jørgensen, EC 2017, 'Maternal serum concentrations of perfluoroalkyl acids in five international birth cohorts', International Journal of Hygiene and Environmental Health, bind 220, nr. 2 Pt A, s. 86–93. https://doi.org/10.1016/j.ijheh.2016.12.005

APA

CBE

MLA

Bjerregaard-Olesen, Christian o.a.. "Maternal serum concentrations of perfluoroalkyl acids in five international birth cohorts". International Journal of Hygiene and Environmental Health. 2017, 220(2 Pt A). 86–93. https://doi.org/10.1016/j.ijheh.2016.12.005

Vancouver

Bjerregaard-Olesen C, Bossi R, Liew Z, Long M, Bech BH, Olsen J o.a. Maternal serum concentrations of perfluoroalkyl acids in five international birth cohorts. International Journal of Hygiene and Environmental Health. 2017 mar;220(2 Pt A):86–93. https://doi.org/10.1016/j.ijheh.2016.12.005

Author

Bjerregaard-Olesen, Christian ; Bossi, Rossana ; Liew, Zeyan ; Long, Manhai ; Bech, Bodil H ; Olsen, Jørn ; Henriksen, Tine B ; Berg, Vivian ; Nøst, Therese H ; Zhang, Jun J ; Bonefeld-Jørgensen, Eva C. / Maternal serum concentrations of perfluoroalkyl acids in five international birth cohorts. I: International Journal of Hygiene and Environmental Health. 2017 ; Bind 220, Nr. 2 Pt A. s. 86–93.

Bibtex

@article{a717df25bd1442fb91cc769c95d2a8c3,
title = "Maternal serum concentrations of perfluoroalkyl acids in five international birth cohorts",
abstract = "BACKGROUND: Perfluoroalkyl acids (PFAAs) are persistent and bioaccumulating compounds, which are spread all over the globe. We aimed to compare the PFAA concentrations in serum from pregnant women in five birth cohorts from four countries (Denmark, China, Norway, and Greenland).METHODS: Serum samples were obtained from the following five birth cohorts including a total of 4718 pregnant women: the Danish National Birth Cohort (DNBC, years 1996-2002, Denmark), the Aarhus Birth Cohort (ABC, years 2008-2013, Denmark), the Shanghai Birth Cohort (SBC, years 2013-2015, China), the Northern Norway Mother-Child Contaminant Cohort (MISA, years 2007-2009, Norway), and the Greenlandic Birth Cohort (ACCEPT, years 2010-2013, Greenland). The samples were analyzed using liquid chromatography triple-quadrupole mass spectrometry. To ensure comparability, all samples except for the MISA samples were measured in the same laboratory. We adjusted the PFAA concentrations for age and parity using analysis of covariance.RESULTS AND DISCUSSION: The mean of the summed concentrations of the seven most abundant PFAAs (∑PFAA) was 37ng/mL in the DNBC, 27ng/mL in the SBC, 21ng/mL in the ACCEPT, 14ng/mL in the MISA cohort, and 12ng/mL in the ABC. The DNBC concentration was highest presumably because these samples were taken in earlier years (i.e. 1996-2002) than the samples from the other cohorts (i.e. 2007-2015), and at a time when the production of PFAAs were at the highest. When excluding the DNBC samples, we found that the concentrations of all the perfluorinated sulfonic acids (PFSAs) and one of the four perfluorinated carboxylic acids (PFCAs) were highest in the Greenlandic women, whereas the other three PFCAs were highest in the Chinese women.CONCLUSION: The concentration and composition of serum PFAAs were similar for the Danish ABC women and the Norwegian MISA women but were otherwise different across the cohorts. The different exposure profiles might partly be related to differences in lifestyle and diet. As the concentrations and compositional patterns vary between the countries, we suggest that the health implications associated with high PFAA exposure might also differ between the countries.",
keywords = "China, Denmark, Exposure profiles, Greenland, Norway, Perfluorinated compounds",
author = "Christian Bjerregaard-Olesen and Rossana Bossi and Zeyan Liew and Manhai Long and Bech, {Bodil H} and J{\o}rn Olsen and Henriksen, {Tine B} and Vivian Berg and N{\o}st, {Therese H} and Zhang, {Jun J} and Bonefeld-J{\o}rgensen, {Eva C}",
note = "Copyright {\circledC} 2016 Elsevier GmbH. All rights reserved.",
year = "2017",
month = "3",
doi = "10.1016/j.ijheh.2016.12.005",
language = "English",
volume = "220",
pages = "86–93",
journal = "International Journal of Hygiene and Environmental Health",
issn = "1438-4639",
publisher = "Elsevier GmbH - Urban und Fischer",
number = "2 Pt A",

}

RIS

TY - JOUR

T1 - Maternal serum concentrations of perfluoroalkyl acids in five international birth cohorts

AU - Bjerregaard-Olesen, Christian

AU - Bossi, Rossana

AU - Liew, Zeyan

AU - Long, Manhai

AU - Bech, Bodil H

AU - Olsen, Jørn

AU - Henriksen, Tine B

AU - Berg, Vivian

AU - Nøst, Therese H

AU - Zhang, Jun J

AU - Bonefeld-Jørgensen, Eva C

N1 - Copyright © 2016 Elsevier GmbH. All rights reserved.

PY - 2017/3

Y1 - 2017/3

N2 - BACKGROUND: Perfluoroalkyl acids (PFAAs) are persistent and bioaccumulating compounds, which are spread all over the globe. We aimed to compare the PFAA concentrations in serum from pregnant women in five birth cohorts from four countries (Denmark, China, Norway, and Greenland).METHODS: Serum samples were obtained from the following five birth cohorts including a total of 4718 pregnant women: the Danish National Birth Cohort (DNBC, years 1996-2002, Denmark), the Aarhus Birth Cohort (ABC, years 2008-2013, Denmark), the Shanghai Birth Cohort (SBC, years 2013-2015, China), the Northern Norway Mother-Child Contaminant Cohort (MISA, years 2007-2009, Norway), and the Greenlandic Birth Cohort (ACCEPT, years 2010-2013, Greenland). The samples were analyzed using liquid chromatography triple-quadrupole mass spectrometry. To ensure comparability, all samples except for the MISA samples were measured in the same laboratory. We adjusted the PFAA concentrations for age and parity using analysis of covariance.RESULTS AND DISCUSSION: The mean of the summed concentrations of the seven most abundant PFAAs (∑PFAA) was 37ng/mL in the DNBC, 27ng/mL in the SBC, 21ng/mL in the ACCEPT, 14ng/mL in the MISA cohort, and 12ng/mL in the ABC. The DNBC concentration was highest presumably because these samples were taken in earlier years (i.e. 1996-2002) than the samples from the other cohorts (i.e. 2007-2015), and at a time when the production of PFAAs were at the highest. When excluding the DNBC samples, we found that the concentrations of all the perfluorinated sulfonic acids (PFSAs) and one of the four perfluorinated carboxylic acids (PFCAs) were highest in the Greenlandic women, whereas the other three PFCAs were highest in the Chinese women.CONCLUSION: The concentration and composition of serum PFAAs were similar for the Danish ABC women and the Norwegian MISA women but were otherwise different across the cohorts. The different exposure profiles might partly be related to differences in lifestyle and diet. As the concentrations and compositional patterns vary between the countries, we suggest that the health implications associated with high PFAA exposure might also differ between the countries.

AB - BACKGROUND: Perfluoroalkyl acids (PFAAs) are persistent and bioaccumulating compounds, which are spread all over the globe. We aimed to compare the PFAA concentrations in serum from pregnant women in five birth cohorts from four countries (Denmark, China, Norway, and Greenland).METHODS: Serum samples were obtained from the following five birth cohorts including a total of 4718 pregnant women: the Danish National Birth Cohort (DNBC, years 1996-2002, Denmark), the Aarhus Birth Cohort (ABC, years 2008-2013, Denmark), the Shanghai Birth Cohort (SBC, years 2013-2015, China), the Northern Norway Mother-Child Contaminant Cohort (MISA, years 2007-2009, Norway), and the Greenlandic Birth Cohort (ACCEPT, years 2010-2013, Greenland). The samples were analyzed using liquid chromatography triple-quadrupole mass spectrometry. To ensure comparability, all samples except for the MISA samples were measured in the same laboratory. We adjusted the PFAA concentrations for age and parity using analysis of covariance.RESULTS AND DISCUSSION: The mean of the summed concentrations of the seven most abundant PFAAs (∑PFAA) was 37ng/mL in the DNBC, 27ng/mL in the SBC, 21ng/mL in the ACCEPT, 14ng/mL in the MISA cohort, and 12ng/mL in the ABC. The DNBC concentration was highest presumably because these samples were taken in earlier years (i.e. 1996-2002) than the samples from the other cohorts (i.e. 2007-2015), and at a time when the production of PFAAs were at the highest. When excluding the DNBC samples, we found that the concentrations of all the perfluorinated sulfonic acids (PFSAs) and one of the four perfluorinated carboxylic acids (PFCAs) were highest in the Greenlandic women, whereas the other three PFCAs were highest in the Chinese women.CONCLUSION: The concentration and composition of serum PFAAs were similar for the Danish ABC women and the Norwegian MISA women but were otherwise different across the cohorts. The different exposure profiles might partly be related to differences in lifestyle and diet. As the concentrations and compositional patterns vary between the countries, we suggest that the health implications associated with high PFAA exposure might also differ between the countries.

KW - China

KW - Denmark

KW - Exposure profiles

KW - Greenland

KW - Norway

KW - Perfluorinated compounds

U2 - 10.1016/j.ijheh.2016.12.005

DO - 10.1016/j.ijheh.2016.12.005

M3 - Journal article

VL - 220

SP - 86

EP - 93

JO - International Journal of Hygiene and Environmental Health

JF - International Journal of Hygiene and Environmental Health

SN - 1438-4639

IS - 2 Pt A

ER -