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Mapping of fertility traits in Finnish Ayrshire by genome-wide association analysis

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Mapping of fertility traits in Finnish Ayrshire by genome-wide association analysis. / Schulmann, Nina F; Sahana, Goutam; Iso-Touru, T; McKay, S D; Schnabel, R D; Lund, Mogens Sandø; Taylor, J F; Virta, J; Vilkki, J H.

I: Animal Genetics, Bind 42, Nr. 3, 06.2011, s. 263-269.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Schulmann, NF, Sahana, G, Iso-Touru, T, McKay, SD, Schnabel, RD, Lund, MS, Taylor, JF, Virta, J & Vilkki, JH 2011, 'Mapping of fertility traits in Finnish Ayrshire by genome-wide association analysis', Animal Genetics, bind 42, nr. 3, s. 263-269. https://doi.org/10.1111/j.1365-2052.2010.02149.x

APA

Schulmann, N. F., Sahana, G., Iso-Touru, T., McKay, S. D., Schnabel, R. D., Lund, M. S., Taylor, J. F., Virta, J., & Vilkki, J. H. (2011). Mapping of fertility traits in Finnish Ayrshire by genome-wide association analysis. Animal Genetics, 42(3), 263-269. https://doi.org/10.1111/j.1365-2052.2010.02149.x

CBE

Schulmann NF, Sahana G, Iso-Touru T, McKay SD, Schnabel RD, Lund MS, Taylor JF, Virta J, Vilkki JH. 2011. Mapping of fertility traits in Finnish Ayrshire by genome-wide association analysis. Animal Genetics. 42(3):263-269. https://doi.org/10.1111/j.1365-2052.2010.02149.x

MLA

Vancouver

Author

Schulmann, Nina F ; Sahana, Goutam ; Iso-Touru, T ; McKay, S D ; Schnabel, R D ; Lund, Mogens Sandø ; Taylor, J F ; Virta, J ; Vilkki, J H. / Mapping of fertility traits in Finnish Ayrshire by genome-wide association analysis. I: Animal Genetics. 2011 ; Bind 42, Nr. 3. s. 263-269.

Bibtex

@article{53a45b8b09e64396b8ca664d60c71c48,
title = "Mapping of fertility traits in Finnish Ayrshire by genome-wide association analysis",
abstract = "A whole-genome scan using single marker association was used to detect chromosome regions associated with seven female fertility traits in Finnish Ayrshire dairy cattle. The phenotypic data consisted of de-regressed estimated breeding values for 340 bulls which were estimated using a single trait model. Genotypes were obtained with the Illumina BovineSNP50 panel and a total of 35 630 informative, high-quality single nucleotide polymorphism (SNP) markers were used. The association analysis was performed using a mixed-model approach which fitted a fixed effect for each SNP and a random polygenic effect. We detected eleven genome-wide significant associations on eight different chromosomes. With at least chromosome-wise significance after Bonferroni correction, sixteen SNPs on nine chromosomes showed significant associations with one or more fertility traits. The results confirmed quantitative trait loci on three chromosomes (1, 2 and 20) for fertility traits previously reported for the same breed and one on chromosome four previously detected in Holstein cattle.",
keywords = "Association, Cattle, Cow, Fertitily, Genome Wide Association (GWA), mapping, quantitative trait loci, single-nucleotide polymorphism, association, cattle, cow, fertility, Genome Wide Association (GWA), mapping, quantitative trait loci, single-nucleotide polymorphism",
author = "Schulmann, {Nina F} and Goutam Sahana and T Iso-Touru and McKay, {S D} and Schnabel, {R D} and Lund, {Mogens Sand{\o}} and Taylor, {J F} and J Virta and Vilkki, {J H}",
year = "2011",
month = jun,
doi = "10.1111/j.1365-2052.2010.02149.x",
language = "English",
volume = "42",
pages = "263--269",
journal = "Animal Genetics",
issn = "0268-9146",
publisher = "Wiley-Blackwell Publishing Ltd.",
number = "3",

}

RIS

TY - JOUR

T1 - Mapping of fertility traits in Finnish Ayrshire by genome-wide association analysis

AU - Schulmann, Nina F

AU - Sahana, Goutam

AU - Iso-Touru, T

AU - McKay, S D

AU - Schnabel, R D

AU - Lund, Mogens Sandø

AU - Taylor, J F

AU - Virta, J

AU - Vilkki, J H

PY - 2011/6

Y1 - 2011/6

N2 - A whole-genome scan using single marker association was used to detect chromosome regions associated with seven female fertility traits in Finnish Ayrshire dairy cattle. The phenotypic data consisted of de-regressed estimated breeding values for 340 bulls which were estimated using a single trait model. Genotypes were obtained with the Illumina BovineSNP50 panel and a total of 35 630 informative, high-quality single nucleotide polymorphism (SNP) markers were used. The association analysis was performed using a mixed-model approach which fitted a fixed effect for each SNP and a random polygenic effect. We detected eleven genome-wide significant associations on eight different chromosomes. With at least chromosome-wise significance after Bonferroni correction, sixteen SNPs on nine chromosomes showed significant associations with one or more fertility traits. The results confirmed quantitative trait loci on three chromosomes (1, 2 and 20) for fertility traits previously reported for the same breed and one on chromosome four previously detected in Holstein cattle.

AB - A whole-genome scan using single marker association was used to detect chromosome regions associated with seven female fertility traits in Finnish Ayrshire dairy cattle. The phenotypic data consisted of de-regressed estimated breeding values for 340 bulls which were estimated using a single trait model. Genotypes were obtained with the Illumina BovineSNP50 panel and a total of 35 630 informative, high-quality single nucleotide polymorphism (SNP) markers were used. The association analysis was performed using a mixed-model approach which fitted a fixed effect for each SNP and a random polygenic effect. We detected eleven genome-wide significant associations on eight different chromosomes. With at least chromosome-wise significance after Bonferroni correction, sixteen SNPs on nine chromosomes showed significant associations with one or more fertility traits. The results confirmed quantitative trait loci on three chromosomes (1, 2 and 20) for fertility traits previously reported for the same breed and one on chromosome four previously detected in Holstein cattle.

KW - Association

KW - Cattle

KW - Cow

KW - Fertitily

KW - Genome Wide Association (GWA)

KW - mapping

KW - quantitative trait loci

KW - single-nucleotide polymorphism

KW - association

KW - cattle

KW - cow

KW - fertility

KW - Genome Wide Association (GWA)

KW - mapping

KW - quantitative trait loci

KW - single-nucleotide polymorphism

U2 - 10.1111/j.1365-2052.2010.02149.x

DO - 10.1111/j.1365-2052.2010.02149.x

M3 - Journal article

C2 - 21554346

VL - 42

SP - 263

EP - 269

JO - Animal Genetics

JF - Animal Genetics

SN - 0268-9146

IS - 3

ER -