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Mapping of fertility traits in Finnish Ayrshire by genome-wide association analysis

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  • Nina F Schulmann, MTT, Agrifood Research Finland, Finland
  • Goutam Sahana
  • T Iso-Touru, MTT, Agrifood Research Finland, Finland
  • S D McKay, University of Missouri, USA
  • R D Schnabel, University of Missouri, USA
  • Mogens Sandø Lund
  • J F Taylor, University of Missouri, USA
  • J Virta, MTT, Agrifood Research Finland, Finland
  • J H Vilkki, 1MTT, Agrifood Research Finland, Finland
A whole-genome scan using single marker association was used to detect chromosome regions associated with seven female fertility traits in Finnish Ayrshire dairy cattle. The phenotypic data consisted of de-regressed estimated breeding values for 340 bulls which were estimated using a single trait model. Genotypes were obtained with the Illumina BovineSNP50 panel and a total of 35 630 informative, high-quality single nucleotide polymorphism (SNP) markers were used. The association analysis was performed using a mixed-model approach which fitted a fixed effect for each SNP and a random polygenic effect. We detected eleven genome-wide significant associations on eight different chromosomes. With at least chromosome-wise significance after Bonferroni correction, sixteen SNPs on nine chromosomes showed significant associations with one or more fertility traits. The results confirmed quantitative trait loci on three chromosomes (1, 2 and 20) for fertility traits previously reported for the same breed and one on chromosome four previously detected in Holstein cattle

OriginalsprogEngelsk
TidsskriftAnimal Genetics
Vol/bind42
Nummer3
Sider (fra-til)263-269
Antal sider7
ISSN0268-9146
DOI
StatusUdgivet - jun. 2011

    Forskningsområder

  • Association, Cattle, Cow, Fertitily, Genome Wide Association (GWA), mapping, quantitative trait loci, single-nucleotide polymorphism

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