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Mapping of a major osteomagenic determinant of murine leukemia virus RFB-14 to non-long terminal repeat sequences

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Mapping of a major osteomagenic determinant of murine leukemia virus RFB-14 to non-long terminal repeat sequences. / Østergaard, Mette; Pedersen, Lene; Schmidt, Jörg et al.

I: Journal of Virology, Bind 71, Nr. 1, 01.1997, s. 645-649.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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APA

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Østergaard M, Pedersen L, Schmidt J, Luz A, Lovmand J, Erfle V, Pedersen FS. 1997. Mapping of a major osteomagenic determinant of murine leukemia virus RFB-14 to non-long terminal repeat sequences. Journal of Virology. 71(1):645-649.

MLA

Vancouver

Østergaard M, Pedersen L, Schmidt J, Luz A, Lovmand J, Erfle V et al. Mapping of a major osteomagenic determinant of murine leukemia virus RFB-14 to non-long terminal repeat sequences. Journal of Virology. 1997 jan.;71(1):645-649.

Author

Østergaard, Mette ; Pedersen, Lene ; Schmidt, Jörg et al. / Mapping of a major osteomagenic determinant of murine leukemia virus RFB-14 to non-long terminal repeat sequences. I: Journal of Virology. 1997 ; Bind 71, Nr. 1. s. 645-649.

Bibtex

@article{e6a743231d74418fb72aa1089f8c7531,
title = "Mapping of a major osteomagenic determinant of murine leukemia virus RFB-14 to non-long terminal repeat sequences",
abstract = "Certain isolates of murine leukemia viruses (MuLVs) have, apart from a leukemogenic potential, the capability of inducing diseases of nonhematopoietic tissues in susceptible strains of mice. We have reported on the molecular cloning of a bone-tumorigenic virus, RFB-14 MuLV, which was found to induce benign bone tumors, osteomas, with 100% incidence in mice of the CBA/Ca strain (L. Pedersen, W. Behnisch, J. Schmidt, A. Luz, F. S. Pedersen, V. Erfle, and P. G. Strauss, J. Virol. 66:6186-6190, 1992). In order to analyze the bone tumor-inducing phenotype of RFB-14 MuLV, we have studied the pathogenic potential of recombinant viruses between RFB-14 and the nonosteomagenic, highly leukemogenic SL3-3 MuLV. The recombinants were constructed so as to reveal whether a major determinant of osteomagenicity maps to sequences within or outside the long terminal repeats (LTR). Our data show that a major determinant of the osteoma-inducing potential of RFB-14 MuLV maps to the non-LTR region of the genome. Furthermore, we demonstrate that a strong determinant of leukemogenicity is harbored by the non-LTR region of SL3-3 MuLV. ",
author = "Mette {\O}stergaard and Lene Pedersen and J{\"o}rg Schmidt and Arne Luz and Jette Lovmand and Volker Erfle and Pedersen, {Finn Skou}",
year = "1997",
month = jan,
language = "English",
volume = "71",
pages = "645--649",
journal = "Journal of Virology",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "1",

}

RIS

TY - JOUR

T1 - Mapping of a major osteomagenic determinant of murine leukemia virus RFB-14 to non-long terminal repeat sequences

AU - Østergaard, Mette

AU - Pedersen, Lene

AU - Schmidt, Jörg

AU - Luz, Arne

AU - Lovmand, Jette

AU - Erfle, Volker

AU - Pedersen, Finn Skou

PY - 1997/1

Y1 - 1997/1

N2 - Certain isolates of murine leukemia viruses (MuLVs) have, apart from a leukemogenic potential, the capability of inducing diseases of nonhematopoietic tissues in susceptible strains of mice. We have reported on the molecular cloning of a bone-tumorigenic virus, RFB-14 MuLV, which was found to induce benign bone tumors, osteomas, with 100% incidence in mice of the CBA/Ca strain (L. Pedersen, W. Behnisch, J. Schmidt, A. Luz, F. S. Pedersen, V. Erfle, and P. G. Strauss, J. Virol. 66:6186-6190, 1992). In order to analyze the bone tumor-inducing phenotype of RFB-14 MuLV, we have studied the pathogenic potential of recombinant viruses between RFB-14 and the nonosteomagenic, highly leukemogenic SL3-3 MuLV. The recombinants were constructed so as to reveal whether a major determinant of osteomagenicity maps to sequences within or outside the long terminal repeats (LTR). Our data show that a major determinant of the osteoma-inducing potential of RFB-14 MuLV maps to the non-LTR region of the genome. Furthermore, we demonstrate that a strong determinant of leukemogenicity is harbored by the non-LTR region of SL3-3 MuLV.

AB - Certain isolates of murine leukemia viruses (MuLVs) have, apart from a leukemogenic potential, the capability of inducing diseases of nonhematopoietic tissues in susceptible strains of mice. We have reported on the molecular cloning of a bone-tumorigenic virus, RFB-14 MuLV, which was found to induce benign bone tumors, osteomas, with 100% incidence in mice of the CBA/Ca strain (L. Pedersen, W. Behnisch, J. Schmidt, A. Luz, F. S. Pedersen, V. Erfle, and P. G. Strauss, J. Virol. 66:6186-6190, 1992). In order to analyze the bone tumor-inducing phenotype of RFB-14 MuLV, we have studied the pathogenic potential of recombinant viruses between RFB-14 and the nonosteomagenic, highly leukemogenic SL3-3 MuLV. The recombinants were constructed so as to reveal whether a major determinant of osteomagenicity maps to sequences within or outside the long terminal repeats (LTR). Our data show that a major determinant of the osteoma-inducing potential of RFB-14 MuLV maps to the non-LTR region of the genome. Furthermore, we demonstrate that a strong determinant of leukemogenicity is harbored by the non-LTR region of SL3-3 MuLV.

M3 - Journal article

VL - 71

SP - 645

EP - 649

JO - Journal of Virology

JF - Journal of Virology

SN - 0022-538X

IS - 1

ER -