Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility

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DOI

  • Ashok Agarwal, Cleveland Clin, Cleveland Clinic Foundation, Dept Urol
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  • Neel Parekh, Cleveland Clin, Cleveland Clinic Foundation, Dept Urol
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  • Manesh Kumar Panner Selvam, Cleveland Clin, Cleveland Clinic Foundation, Dept Urol
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  • Ralf Henkel, Univ Western Cape, University of the Western Cape, Dept Med Biosci
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  • Rupin Shah, Lilavati Hosp & Res Ctr, Dept Urol
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  • Sheryl T. Homa, Univ Kent, University of Kent, Sch Biosci
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  • Ranjith Ramasamy, Univ Miami, University of Miami, Dept Urol
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  • Edmund Ko, Loma Linda Univ Hlth, Loma Linda University, Dept Urol
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  • Kelton Tremellen, Flinders Univ S Australia, Flinders University South Australia, Dept Obstet Gynaecol & Reprod Med
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  • Sandro Esteves, Univ Campinas UNICAMP, Universidade Estadual de Campinas, Dept Surg, Div Urol
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  • Ahmad Majzoub, Weill Cornell Med Qatar, Weill Cornell Medical College Qatar
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  • Juan G. Alvarez, Harvard Med Sch, Harvard University, Harvard Medical School, Dept Psychiat
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  • David K. Gardner, Univ Melbourne, University of Melbourne, Sch BioSci, Metabol Australia
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  • Channa N. Jayasena, Hammersmith Hosp, Imperial College London, Dept Androl
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  • Jonathan W. Ramsay, Hammersmith Hosp, Imperial College London, Dept Androl
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  • Chak-Lam Cho, Union Hosp, Dept Surg, Shatin
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  • Ramadan Saleh, Sohag Univ, Sohag University, Fac Med, Dept Dermatol Venereol & Androl
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  • Denny Sakkas, Boston IVF
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  • James M. Hotaling, Univ Utah, Utah System of Higher Education, University of Utah, Dept Urol
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  • Scott D. Lundy, Cleveland Clin, Cleveland Clinic Foundation, Dept Urol
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  • Sarah Vij, Cleveland Clin, Cleveland Clinic Foundation, Dept Urol
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  • Joel Marmar, Cooper Univ Hosp, Cooper University Hospital
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  • Jaime Gosalvez, Univ Autonoma Madrid, Autonomous University of Madrid, Dept Biol Mol
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  • Edmund Sabanegh, Cleveland Clin, Cleveland Clinic Foundation, Dept Urol
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  • Hyun Jun Park, Pusan Natl Univ Hosp, Pusan National University, Pusan National University Hospital, Med Res Inst
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  • Armand Zini, McGill Univ, McGill University, Dept Surg
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  • Parviz Kavoussi, Austin Fertil & Reprod Med Westlake IVF
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  • Sava Micic, Uromed Polyclin
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  • Ryan Smith, Univ Virginia, University of Virginia, Dept Urol
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  • Gian Maria Busetto, Sapienza Univ Rome, Sapienza University Rome, Dept Biol & Biotechnol
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  • Mustafa Emre Bakircioglu, Istanbul Florence Nightingale Hosp, Grup Florence Nigtingale Hospital Turkey
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  • Gerhard Haidl, Univ Hosp Bonn, University of Bonn, Dept Dermatol
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  • Giancarlo Balercia, Polytech Univ Marche, Marche Polytechnic University, Umberto I Hosp, Dept Clin & Mol Sci, Div Endocrinol
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  • Nicols Garrido Puchalt, IVI Fdn Edificio Biopolo, Inst Invest Sanitaria la Fe
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  • Moncef Ben-Khalifa, PERITOX Lab
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  • Nicholas Tadros, Southern Illinois Univ, Southern Illinois University System, Southern Illinois University, Sch Med, Div Urol
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  • Jackson Kirkman-Browne, Birmingham Womens & Childrens NHS Fdn Trust, Birmingham Womens Fertil Ctr
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  • Sergey Moskovtsev, Univ Toronto, University of Toronto, Dept Obstet & Gynaecol
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  • Xuefeng Huang, Wenzhou Med Univ, Wenzhou Medical University, Reprod Med Ctr, Affiliated Hosp 1
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  • Edson Borges, Fertil Med Grp
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  • Daniel Franken, Tygerberg Hosp, Tygerberg Hospital, Fac Hlth Sci, Dept Obstet & Gynecol, Androl Unit
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  • Natan Bar-Chama, Icahn Sch Med Mt Sinai, Icahn School of Medicine at Mount Sinai, Dept Urol
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  • Yoshiharu Morimoto, Horac Grand Front Osaka Clin, IVF Japan Grp
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  • Kazuhisa Tomita, Horac Grand Front Osaka Clin, IVF Japan Grp
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  • Vasan Satya Srini, Manipal Fertil
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  • Willem Ombelet, Hasselt Univ, Hasselt University, Biomed Res Inst BIOMED
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  • Elisabetta Baldi, Univ Florence, University of Florence, Ctr Excellence DeNothe, Dept Expt & Clin Med
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  • Monica Muratori, Univ Florence, University of Florence, Ctr Excellence DeNothe, Dept Expt & Clin Biomed Sci Mario Serio, Unit Sexual Med & Androl
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  • Yasushi Yumura, Yokohama City Univ, Yokohama City University, Reprod Ctr, Dept Urol, Med Ctr
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  • Sandro La Vignera, Univ Catania, University of Catania, Univ Hosp Policlin Vitt Emanuele, Dept Clin & Expt Med
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  • Raghavender Kosgi, Androbest Androl & Urol Ctr
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  • Marlon P. Martinez, Univ Santo Tomas Hosp, University of Santo Tomas, Sect Urol
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  • Donald P. Evenson, SCSA Diagnost
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  • Daniel Suslik Zylbersztejn, Hosp Israelita Albert Einstein, Hospital Israelita Albert Einstein
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  • Matheus Roque, ORIGEN, Ctr Reprod Med
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  • Marcello Cocuzza, Univ Sao Paulo, Universidade de Sao Paulo, Dept Urol
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  • Marcelo Vieira, Brazilian Soc Urol, Male Infertil Div, Androl Dept
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  • Assaf Ben-Meir, Hebrew Univ Jerusalem, Hebrew University of Jerusalem, Dept Obstet & Gynecol, Fertil & IVF Unit, Hadassah Med Ctr
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  • Raoul Orvieto, Tel Aviv Univ, Tel Aviv University, Sackler Faculty of Medicine, Sackler Fac Med, Tarnesby Tarnowski Chair Family Planning & Fertil
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  • Eliahu Levitas, Ben Gurion Univ Negev Beer Sheva, Ben Gurion University, Soroka Medical Center, Soroka Univ Med Ctr
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  • Amir Wiser, Tel Aviv Univ, Tel Aviv University, Sackler Faculty of Medicine, Sackler Sch Med, Dept Family Med
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  • Mohamed Arafa, Hamad Med Corp, Hamad Medical Corporation, Dept Urol
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  • Vineet Malhotra, Diyos Hosp, Dept Androl & Urol
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  • Sijo Joseph Parekattil, Univ Cent Florida, Florida State University System, University of Central Florida, Dept Phys
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  • Haitham Elbardisi, Hamad Med Corp, Hamad Medical Corporation, Dept Urol
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  • Luiz Carvalho, Coll Inst Clin Res & Teaching Dev
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  • Rima Dada, All India Inst Med Sci, All India Institute of Medical Sciences (AIIMS) New Delhi, Lab Mol Reprod & Genet, Anat
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  • Christophe Sifer, Hop Univ Paris Seine St Denis, Assistance Publique Hopitaux Paris (APHP), Hopital Universitaire Jean-Verdier - APHP, Dept Reprod Biol
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  • Pankaj Talwar, Manipal Hosp, Dept Reprod Med & Embryol
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  • Ahmet Gudeloglu, Hacettepe Univ, Hacettepe University, Dept Urol, Fac Med
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  • Ahmed M. A. Mahmoud, Univ Hosp Ghent, Ghent University, Ghent University Hospital, Dept Endocrinol Androl
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  • Khaled Terras, Hannibal Int Clin, Dept Reprod Med
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  • Chadi Yazbeck, Hartman Clin, Dept Obstet Gynecol & Reprod Med
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  • Bojanic Nebojsa, University of Belgrade
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  • Damayanthi Durairajanayagam, Univ Teknol MARA, Universiti Teknologi MARA, Fac Med, Dept Physiol
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  • Ajina Mounir, Univ Sousse, Universite de Sousse, Fac Med, Dept Embryol
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  • Linda G. Kahn, NYU, New York University, Dept Pediat, Sch Med
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  • Saradha Baskaran, Cleveland Clin, Cleveland Clinic Foundation, Amer Ctr Reprod Med
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  • Rishma Dhillon Pai, Lilavati Hosp & Res Ctr, Dept Obstet & Gynaecol
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  • Donatella Paoli, Sapienza Univ Rome, Sapienza University Rome, Dept Expt Med
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  • Kristian Leisegang, Univ Western Cape, University of the Western Cape, Sch Nat Med
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  • Mohamed-Reza Moein, Shahid Sadoughi Med Univ, Dept Androl
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  • Sonia Malik, Southend Fertil & IVF
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  • Onder Yaman, Univ Ankara, Ankara University, Sch Med, Dept Urol
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  • Luna Samanta, Ravenshaw Univ, Ravenshaw University, Ctr Excellence Environm & Publ Hlth
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  • Fouad Bayane, Marrakech Fertil Inst
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  • Sunil K. Jindal, Jindal Hosp
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  • Muammer Kendirci, Istinye Univ, Ankara Liv Hospital, Istinye University, Liv Hosp Ulus, Dept Urol, Fac Med
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  • Baris Altay, Ege Univ, Ege University, Dept Urol, Sch Med
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  • Dragoljub Perovic, CODRA Hosp, Ctr Urol
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  • Avi Harlev, Ben Gurion Univ Negev, Ben Gurion University, Soroka Medical Center, Soroka Univ Med Ctr, Fertil & IVF Unit

Despite advances in the field of male reproductive health, idiopathic male infertility, in which a man has altered semen characteristics without an identifiable cause and there is no female factor infertility, remains a challenging condition to diagnose and manage. Increasing evidence suggests that oxidative stress (OS) plays an independent role in the etiology of male infertility, with 30% to 80% of infertile men having elevated seminal reactive oxygen species levels. OS can negatively affect fertility via a number of pathways, including interference with capacitation and possible damage to sperm membrane and DNA, which may impair the sperm's potential to fertilize an egg and develop into a healthy embryo. Adequate evaluation of male reproductive potential should therefore include an assessment of sperm OS. We propose the term Male Oxidative Stress Infertility, or MOSI, as a novel descriptor for infertile men with abnormal semen characteristics and OS, including many patients who were previously classified as having idiopathic male infertility. Oxidation-reduction potential (ORP) can be a useful clinical biomarker for the classification of MOSI, as it takes into account the levels of both oxidants and reductants (antioxidants). Current treatment protocols for OS, including the use of antioxidants, are not evidence-based and have the potential for complications and increased healthcare-related expenditures. Utilizing an easy, reproducible, and cost-effective test to measure ORP may provide a more targeted, reliable approach for administering antioxidant therapy while minimizing the risk of antioxidant overdose. With the increasing awareness and understanding of MOSI as a distinct male infertility diagnosis, future research endeavors can facilitate the development of evidence-based treatments that target its underlying cause.

OriginalsprogEngelsk
TidsskriftWorld journal of mens health
Vol/bind37
Nummer3
Sider (fra-til)296-312
Antal sider17
ISSN2287-4208
DOI
StatusUdgivet - sep. 2019

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