Magnetic Resonance–Guided Focused Ultrasound Treatment for Essential Tremor: A Single-Center Experience

Victor Hvingelby; Pernille Louise Kjeldsen; Bo Bergholt; Gastón Schechtmann; Erik Hvid Danielsen; Mette Møller; Erik Lisbjerg Johnsen; Skirmante Mardosiene; Torben Ellegaard Lund; Dora Grauballe; Michael Geneser; Tina Vincens  Sørensen; Lisa Østergaard Bak; Martin Andreasen; Anne Sofie Møller Andersen; Lone  Andersen; Kaare Meier; Niels  Juhl; Alp Tankisi; Bo Jespersen; Christian Fenger-Eriksen; Mads Rasmussen; Winnie  Bechmann Eriksen; Birgitte Barrutia; Mette Kromann; Ida Baandrup; Jette  Bjørn; Rie Stjernholm; Charlotte Braemer-Madsen; Signe Mygdal Jørgensen; Jens Christian Hedemann Sørensen; Andreas  Glud

doi:10.1002/mdc3.70012

Magnetic Resonance–Guided Focused Ultrasound Treatment for Essential Tremor: A Single-Center Experience

Victor Hvingelby^*, Pernille Louise Kjeldsen, Bo Bergholt, Gastón Schechtmann, Erik Hvid Danielsen, Mette Møller, Erik Lisbjerg Johnsen, Skirmante Mardosiene, Torben Ellegaard Lund, Dora Grauballe, Michael Geneser, Tina Vincens Sørensen, Lisa Østergaard Bak, Martin Andreasen, Anne Sofie Møller Andersen, Lone Andersen, Kaare Meier, Niels Juhl, Alp Tankisi, Bo JespersenChristian Fenger-Eriksen, Mads Rasmussen, Winnie Bechmann Eriksen, Birgitte Barrutia, Mette Kromann, Ida Baandrup, Jette Bjørn, Rie Stjernholm, Charlotte Braemer-Madsen, Signe Mygdal Jørgensen, Jens Christian Hedemann Sørensen, Andreas Glud

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Abstract

Background: Essential tremor is the most common hyperkinetic movement disorder. Magnetic resonance imaging–guided focused ultrasound (MRgFUS) has emerged as second-line therapy. Objective: The aim was to obtain the results of the first 108 patients treated with MRgFUS in Denmark. Methods: Data were entered in a quality assurance database at baseline and 3, 6, and 12 months. Clinician- and patient-rated treatment efficacy was evaluated using the Fahn–Marin–Tolosa (FMT) scale and the Patient Global Impression of Change. Results: A total of 108 persons have currently been treated. Tremor improved by a total mean 6.39 points (95% confidence interval [CI]: 5.01;7.76, P < 0.00001) and 9.63 points (95% CI: 7.60;11.66, P < 0.00001), 10.42 (95% CI: 9.06;11.79, P < 0.00001), and 26.45 (95% CI: 22.46;30.43, P < 0.00001) for FMT parts A, B, and C, respectively, at 3 months. Side effects occurred in 65.7% of patients at 3 months and 33.7% at 12 months. Conclusion: Our findings are in line with existing evidence. Questions regarding persistence of gait- and balance-related side effects remain.

Originalsprog	Engelsk
Tidsskrift	Movement Disorders Clinical Practice
ISSN	2330-1619
DOI	https://doi.org/10.1002/mdc3.70012
Status	E-pub / Early view - 19 feb. 2025

Emneord

Essential tremor
Focused ultrasound
Magnetic resonance imaging

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10.1002/mdc3.70012

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Hvingelby, V., Kjeldsen, P. L., Bergholt, B., Schechtmann, G., Danielsen, E. H., Møller, M., Johnsen, E. L., Mardosiene, S., Lund, T. E., Grauballe, D., Geneser, M., Sørensen, T. V., Bak, L. Ø., Andreasen, M., Andersen, A. S. M., Andersen, L., Meier, K., Juhl, N., Tankisi, A., ... Glud, A. (2025). Magnetic Resonance–Guided Focused Ultrasound Treatment for Essential Tremor: A Single-Center Experience. Movement Disorders Clinical Practice. Advance online publication. https://doi.org/10.1002/mdc3.70012

@article{19a903eac3674c6e9176d59a0891bc86,

title = "Magnetic Resonance–Guided Focused Ultrasound Treatment for Essential Tremor: A Single-Center Experience",

abstract = "Background: Essential tremor is the most common hyperkinetic movement disorder. Magnetic resonance imaging–guided focused ultrasound (MRgFUS) has emerged as second-line therapy. Objective: The aim was to obtain the results of the first 108 patients treated with MRgFUS in Denmark. Methods: Data were entered in a quality assurance database at baseline and 3, 6, and 12 months. Clinician- and patient-rated treatment efficacy was evaluated using the Fahn–Marin–Tolosa (FMT) scale and the Patient Global Impression of Change. Results: A total of 108 persons have currently been treated. Tremor improved by a total mean 6.39 points (95% confidence interval [CI]: 5.01;7.76, P < 0.00001) and 9.63 points (95% CI: 7.60;11.66, P < 0.00001), 10.42 (95% CI: 9.06;11.79, P < 0.00001), and 26.45 (95% CI: 22.46;30.43, P < 0.00001) for FMT parts A, B, and C, respectively, at 3 months. Side effects occurred in 65.7% of patients at 3 months and 33.7% at 12 months. Conclusion: Our findings are in line with existing evidence. Questions regarding persistence of gait- and balance-related side effects remain.",

keywords = "Essential tremor, Focused ultrasound, Magnetic resonance imaging",

author = "Victor Hvingelby and Kjeldsen, {Pernille Louise} and Bo Bergholt and Gast{\'o}n Schechtmann and Danielsen, {Erik Hvid} and Mette M{\o}ller and Johnsen, {Erik Lisbjerg} and Skirmante Mardosiene and Lund, {Torben Ellegaard} and Dora Grauballe and Michael Geneser and S{\o}rensen, {Tina Vincens} and Bak, {Lisa {\O}stergaard} and Martin Andreasen and Andersen, {Anne Sofie M{\o}ller} and Lone Andersen and Kaare Meier and Niels Juhl and Alp Tankisi and Bo Jespersen and Christian Fenger-Eriksen and Mads Rasmussen and {Bechmann Eriksen}, Winnie and Birgitte Barrutia and Mette Kromann and Ida Baandrup and Jette Bj{\o}rn and Rie Stjernholm and Charlotte Braemer-Madsen and J{\o}rgensen, {Signe Mygdal} and S{\o}rensen, {Jens Christian Hedemann} and Andreas Glud",

note = "Publisher Copyright: {\textcopyright} 2025 The Author(s). Movement Disorders Clinical Practice published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.",

year = "2025",

month = feb,

day = "19",

doi = "10.1002/mdc3.70012",

language = "English",

journal = "Movement Disorders Clinical Practice",

issn = "2330-1619",

publisher = "John Wiley and Sons Ltd",

}

Hvingelby, V , Kjeldsen, PL, Bergholt, B, Schechtmann, G, Danielsen, EH, Møller, M, Johnsen, EL, Mardosiene, S, Lund, TE , Grauballe, D , Geneser, M, Sørensen, TV, Bak, LØ, Andreasen, M, Andersen, ASM, Andersen, L, Meier, K, Juhl, N, Tankisi, A, Jespersen, B, Fenger-Eriksen, C , Rasmussen, M, Bechmann Eriksen, W, Barrutia, B, Kromann, M, Baandrup, I, Bjørn, J, Stjernholm, R, Braemer-Madsen, C, Jørgensen, SM, Sørensen, JCH & Glud, A 2025, 'Magnetic Resonance–Guided Focused Ultrasound Treatment for Essential Tremor: A Single-Center Experience', Movement Disorders Clinical Practice. https://doi.org/10.1002/mdc3.70012

TY - JOUR

T1 - Magnetic Resonance–Guided Focused Ultrasound Treatment for Essential Tremor

T2 - A Single-Center Experience

AU - Hvingelby, Victor

AU - Kjeldsen, Pernille Louise

AU - Bergholt, Bo

AU - Schechtmann, Gastón

AU - Danielsen, Erik Hvid

AU - Møller, Mette

AU - Johnsen, Erik Lisbjerg

AU - Mardosiene, Skirmante

AU - Lund, Torben Ellegaard

AU - Grauballe, Dora

AU - Geneser, Michael

AU - Sørensen, Tina Vincens

AU - Bak, Lisa Østergaard

AU - Andreasen, Martin

AU - Andersen, Anne Sofie Møller

AU - Andersen, Lone

AU - Meier, Kaare

AU - Juhl, Niels

AU - Tankisi, Alp

AU - Jespersen, Bo

AU - Fenger-Eriksen, Christian

AU - Rasmussen, Mads

AU - Bechmann Eriksen, Winnie

AU - Barrutia, Birgitte

AU - Kromann, Mette

AU - Baandrup, Ida

AU - Bjørn, Jette

AU - Stjernholm, Rie

AU - Braemer-Madsen, Charlotte

AU - Jørgensen, Signe Mygdal

AU - Sørensen, Jens Christian Hedemann

AU - Glud, Andreas

PY - 2025/2/19

Y1 - 2025/2/19

N2 - Background: Essential tremor is the most common hyperkinetic movement disorder. Magnetic resonance imaging–guided focused ultrasound (MRgFUS) has emerged as second-line therapy. Objective: The aim was to obtain the results of the first 108 patients treated with MRgFUS in Denmark. Methods: Data were entered in a quality assurance database at baseline and 3, 6, and 12 months. Clinician- and patient-rated treatment efficacy was evaluated using the Fahn–Marin–Tolosa (FMT) scale and the Patient Global Impression of Change. Results: A total of 108 persons have currently been treated. Tremor improved by a total mean 6.39 points (95% confidence interval [CI]: 5.01;7.76, P < 0.00001) and 9.63 points (95% CI: 7.60;11.66, P < 0.00001), 10.42 (95% CI: 9.06;11.79, P < 0.00001), and 26.45 (95% CI: 22.46;30.43, P < 0.00001) for FMT parts A, B, and C, respectively, at 3 months. Side effects occurred in 65.7% of patients at 3 months and 33.7% at 12 months. Conclusion: Our findings are in line with existing evidence. Questions regarding persistence of gait- and balance-related side effects remain.

AB - Background: Essential tremor is the most common hyperkinetic movement disorder. Magnetic resonance imaging–guided focused ultrasound (MRgFUS) has emerged as second-line therapy. Objective: The aim was to obtain the results of the first 108 patients treated with MRgFUS in Denmark. Methods: Data were entered in a quality assurance database at baseline and 3, 6, and 12 months. Clinician- and patient-rated treatment efficacy was evaluated using the Fahn–Marin–Tolosa (FMT) scale and the Patient Global Impression of Change. Results: A total of 108 persons have currently been treated. Tremor improved by a total mean 6.39 points (95% confidence interval [CI]: 5.01;7.76, P < 0.00001) and 9.63 points (95% CI: 7.60;11.66, P < 0.00001), 10.42 (95% CI: 9.06;11.79, P < 0.00001), and 26.45 (95% CI: 22.46;30.43, P < 0.00001) for FMT parts A, B, and C, respectively, at 3 months. Side effects occurred in 65.7% of patients at 3 months and 33.7% at 12 months. Conclusion: Our findings are in line with existing evidence. Questions regarding persistence of gait- and balance-related side effects remain.

KW - Essential tremor

KW - Focused ultrasound

KW - Magnetic resonance imaging

UR - http://www.scopus.com/inward/record.url?scp=85219730605&partnerID=8YFLogxK

U2 - 10.1002/mdc3.70012

DO - 10.1002/mdc3.70012

M3 - Journal article

C2 - 39968962

AN - SCOPUS:85219730605

SN - 2330-1619

JO - Movement Disorders Clinical Practice

JF - Movement Disorders Clinical Practice

ER -

Magnetic Resonance–Guided Focused Ultrasound Treatment for Essential Tremor: A Single-Center Experience

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