Macular oedema and changes in macular thickness in multiple sclerosis patients treated with fingolimod

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  • Thomas Lohne Nørgaard, Aalborg Universitet, Danmark
  • Carl Uggerhøj Andersen, Aalborg Universitet
  • ,
  • Claudia Hilt, Aalborg Universitet, Danmark
  • Charlotte Uggerhøj Andersen
Macular oedema is a known side effect to fingolimod, but changes in specific areas of the retina are only sparsely described. Our aim was to investigate the prevalence of macular oedema and characterize macular changes after initiation of fingolimod based on routine ophthalmological examinations in all consecutive patients treated at our hospital. We evaluated macular thickness change from baseline to 3-4 months after initiation of treatment. Central retinal thickness, total macular volume, total macular thickness, average thickness and inner-/outer macular thickness were automatically measured using optical coherence tomography (OCT). A total of 190 eyes completed the study, and none of those developed visible macular oedema. All macular areas showed a small, but statistically significant increase in thickness. Total macular volume increased by a mean of 0.05 mm3 (P = <.001). Mean best-corrected visual acuity only changed by .03 (P = .074). We observed a minimal change in macular thickness and no clinically relevant affection on visual acuity after 3-4 months of fingolimod treatment. Thus, our results do not underpin the need for routine screening for macular oedema in asymptomatic MS patients without diabetes or uveitis receiving 0.5 mg fingolimod daily.
TidsskriftBasic & Clinical Pharmacology & Toxicology
Sider (fra-til)492-497
Antal sider6
StatusUdgivet - jun. 2020

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