Low serum DHEA-S is associated with impaired lung function in women

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  • Giancarlo Pesce, Sorbonne Université and INSERM UMR-S 1136
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  • Kai Triebner, University of Bergen
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  • Diana A. van der Plaat, Imperial College London
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  • Dominique Courbon, Institut National de la Santé et de la Recherche Médicale
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  • Steinar Hustad, University of Bergen
  • ,
  • Torben Sigsgaard
  • Dennis Nowak, Ludwig Maximilian University of Munich
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  • Joachim Heinrich, Ludwig Maximilian University of Munich, Helmholtz Zentrum München - German Research Center for Environmental Health
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  • Josep M. Anto, Barcelona Institute for Global Health, Pompeu Fabra University, CIBER - Center for Biomedical Research Network
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  • Sandra Dorado-Arenas, Hospital de Galdakao
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  • Jesús Martinez-Moratalla, Complejo Hospitalario Universitario de Albacete
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  • Jose A. Gullon-Blanco, Hospital San Agustin
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  • José L. Sanchez-Ramos, University of Huevla
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  • Chantal Raherison, Universite de Bordeaux
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  • Isabelle Pin, Universite Grenoble Alpes
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  • Pascal Demoly, Sorbonne Université and INSERM UMR-S 1136
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  • Thorarinn Gislason, National University Hospital Reykjavik, University of Iceland
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  • Kjell Torén, University of Gothenburg
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  • Bertil Forsberg, Umeå University
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  • Eva Lindberg, Allergy and Sleep research
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  • Elisabeth Zemp, Swiss Tropical and Public Health Institute, University of Basel
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  • Rain Jogi, University of Tartu
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  • Nicole Probst-Hensch, Swiss Tropical and Public Health Institute, University of Basel
  • ,
  • Shyamali C. Dharmage, University of Melbourne
  • ,
  • Debbie Jarvis, Imperial College London
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  • Judith Garcia-Aymerich, Barcelona Institute for Global Health, Pompeu Fabra University, CIBER - Center for Biomedical Research Network
  • ,
  • Alessandro Marcon, University of Verona
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  • Francisco Gómez-Real, University of Bergen
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  • Bénédicte Leynaert, Universite Paris-Saclay

Background: Emerging evidence suggests that androgens and estrogens have a role in respiratory health, but it is largely unknown whether levels of these hormones can affect lung function in adults from the general population. This study investigated whether serum dehydroepiandrosterone sulfate (DHEA-S), a key precursor of both androgens and estrogens in peripheral tissues, was related to lung function in adult women participating in the European Community Respiratory Health Survey (ECRHS). Methods: Lung function and serum DHEA-S concentrations were measured in n = 2,045 and n = 1,725 women in 1999–2002 and in 2010–2013, respectively. Cross-sectional associations of DHEA-S levels (expressed as age-adjusted z-score) with spirometric outcomes were investigated, adjusting for smoking habits, body mass index, menopausal status, and use of corticosteroids. Longitudinal associations of DHEA-S levels in 1999–2002 with incidence of restrictive pattern and airflow limitation in 2010–2013 were also assessed. Findings: Women with low DHEA-S (z-score<-1) had lower FEV1 (% of predicted, adjusted difference: -2.2; 95%CI: -3.5 to -0.9) and FVC (-1.7; 95%CI: -2.9 to -0.5) and were at a greater risk of having airflow limitation and restrictive pattern on spirometry than women with higher DHEA-S levels. In longitudinal analyses, low DHEA-S at baseline was associated with a greater incidence of airflow limitation after an 11-years follow-up (incidence rate ratio, 3.43; 95%CI: 1.91 to 6.14). Interpretation: Low DHEA-S levels in women were associated with impaired lung function and a greater risk of developing airflow limitation later in adult life. Our findings provide new evidence supporting a role of DHEA-S in respiratory health. Funding: EU H2020, grant agreement no.633212

OriginalsprogEngelsk
Artikelnummer100389
TidsskriftEClinicalMedicine
Vol/bind23
Antal sider8
ISSN2589-5370
DOI
StatusUdgivet - jun. 2020

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