Low physical activity is associated with impaired endothelial function in patients with type 2 diabetes and controls after 5 years of follow-up

TY - JOUR

T1 - Low physical activity is associated with impaired endothelial function in patients with type 2 diabetes and controls after 5 years of follow-up

AU - Baier, Jonathan Mathias

AU - Funck, Kristian Løkke

AU - Vernstrøm, Liv

AU - Laugesen, Esben

AU - Poulsen, Per Løgstrup

N1 - © 2021. The Author(s).

PY - 2021/12

Y1 - 2021/12

N2 - BACKGROUND: The long-term association between physical activity and endothelial function has not previously been investigated in patients with type 2 diabetes. Therefore, we aimed to evaluate the relationship between physical activity and endothelial function, assessed by peripheral arterial tonometry, in patients with type 2 diabetes and non-diabetic controls after 5 years of follow-up.METHODS: We included 51 patients with newly diagnosed type 2 diabetes and 53 sex- and age matched controls. Participants underwent baseline clinical characterization including objective measurement of physical activity level using accelerometery. After 5 years of follow-up, participants were re-examined, and endothelial function was assessed as natural logarithm of reactive hyperemia index (lnRHI).RESULTS: Physical activity at baseline was associated with lnRHI after 5 years of follow-up in both patients with type 2 diabetes and controls. An increase of 1 standard deviation (SD) in daytime physical activity corresponded to a 6.7 % increase in RHI (95 % confidence interval: 1.1;12.5 %, p = 0.02). We found no difference in lnRHI between patients with diabetes and controls (0.67 ± 0.29 vs. 0.73 ± 0.31, p = 0.28).CONCLUSIONS: Daytime physical activity is associated with endothelial function after 5 years of follow-up in patients with type 2 diabetes and controls.

AB - BACKGROUND: The long-term association between physical activity and endothelial function has not previously been investigated in patients with type 2 diabetes. Therefore, we aimed to evaluate the relationship between physical activity and endothelial function, assessed by peripheral arterial tonometry, in patients with type 2 diabetes and non-diabetic controls after 5 years of follow-up.METHODS: We included 51 patients with newly diagnosed type 2 diabetes and 53 sex- and age matched controls. Participants underwent baseline clinical characterization including objective measurement of physical activity level using accelerometery. After 5 years of follow-up, participants were re-examined, and endothelial function was assessed as natural logarithm of reactive hyperemia index (lnRHI).RESULTS: Physical activity at baseline was associated with lnRHI after 5 years of follow-up in both patients with type 2 diabetes and controls. An increase of 1 standard deviation (SD) in daytime physical activity corresponded to a 6.7 % increase in RHI (95 % confidence interval: 1.1;12.5 %, p = 0.02). We found no difference in lnRHI between patients with diabetes and controls (0.67 ± 0.29 vs. 0.73 ± 0.31, p = 0.28).CONCLUSIONS: Daytime physical activity is associated with endothelial function after 5 years of follow-up in patients with type 2 diabetes and controls.

KW - Accelerometery

KW - EndoPAT

KW - Endothelial dysfunction

KW - Endothelial function

KW - Peripheral arterial tonometry

KW - Physical activity

KW - Reactive hyperemia index

KW - Type 2 diabetes

U2 - 10.1186/s12902-021-00857-9

DO - 10.1186/s12902-021-00857-9

M3 - Journal article

C2 - 34535107

SN - 1472-6823

VL - 21

JO - BMC Endocrine Disorders

JF - BMC Endocrine Disorders

IS - 1

M1 - 189

ER -