Low doses of nanodiamonds and silica nanoparticles have beneficial hormetic effects in normal human skin fibroblasts in culture

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Low doses of nanodiamonds and silica nanoparticles have beneficial hormetic effects in normal human skin fibroblasts in culture. / Mytych, Jennifer; Wnuk, Maciej; Rattan, Suresh.

I: Chemosphere, Bind 148, Nr. 1, 26.01.2016, s. 307-315.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{ad2b26b00a794afeadaf805ddaddf514,
title = "Low doses of nanodiamonds and silica nanoparticles have beneficial hormetic effects in normal human skin fibroblasts in culture",
abstract = "Nanodiamonds (ND) and silica nanoparticles (SiO2-NP) have been much investigated for their toxicity at high doses, little is known about their biological activity at low concentrations. Here we report the biphasic dose response of ND and SiO2-NP in modulating normal human facial skin fibroblasts (FSF1) in culture. ND and SiO2-NP at low concentration (up to 0.5 μg/ml) had beneficial effects on FSF1 in terms of increasing their proliferation and metabolic activity. Exposure of FSF1 cells to low levels of NP enhanced their wound healing ability in vitro and slowed down aging during serial passaging as measured by maintenance of youthful morphology, reduction in the rate of loss of telomeres, and the over all proliferative characterisitics. Furthermore, NP treatment induced the activation of Nrf2- and FOXO3A mediated cellular stress responses, including an increased expression of heme oxygenease HO-1), sirtuin (SIRT1), and DNA methyltransferase II (DNMT2). These results imply that ND and SiO2-NP at low doses are potential hormetins, which exert mild stress-induced beneficial hormetic effects through improved survival, longevity, maintenance, repair andfunction of human cells",
keywords = "nanoparticle, stress, hormesis, ageing, anti-ageing, longevity, health",
author = "Jennifer Mytych and Maciej Wnuk and Suresh Rattan",
year = "2016",
month = "1",
day = "26",
doi = "10.1016/j.chemosphere.2016.01.045",
language = "English",
volume = "148",
pages = "307--315",
journal = "Chemosphere",
issn = "0045-6535",
publisher = "Pergamon Press",
number = "1",

}

RIS

TY - JOUR

T1 - Low doses of nanodiamonds and silica nanoparticles have beneficial hormetic effects in normal human skin fibroblasts in culture

AU - Mytych, Jennifer

AU - Wnuk, Maciej

AU - Rattan, Suresh

PY - 2016/1/26

Y1 - 2016/1/26

N2 - Nanodiamonds (ND) and silica nanoparticles (SiO2-NP) have been much investigated for their toxicity at high doses, little is known about their biological activity at low concentrations. Here we report the biphasic dose response of ND and SiO2-NP in modulating normal human facial skin fibroblasts (FSF1) in culture. ND and SiO2-NP at low concentration (up to 0.5 μg/ml) had beneficial effects on FSF1 in terms of increasing their proliferation and metabolic activity. Exposure of FSF1 cells to low levels of NP enhanced their wound healing ability in vitro and slowed down aging during serial passaging as measured by maintenance of youthful morphology, reduction in the rate of loss of telomeres, and the over all proliferative characterisitics. Furthermore, NP treatment induced the activation of Nrf2- and FOXO3A mediated cellular stress responses, including an increased expression of heme oxygenease HO-1), sirtuin (SIRT1), and DNA methyltransferase II (DNMT2). These results imply that ND and SiO2-NP at low doses are potential hormetins, which exert mild stress-induced beneficial hormetic effects through improved survival, longevity, maintenance, repair andfunction of human cells

AB - Nanodiamonds (ND) and silica nanoparticles (SiO2-NP) have been much investigated for their toxicity at high doses, little is known about their biological activity at low concentrations. Here we report the biphasic dose response of ND and SiO2-NP in modulating normal human facial skin fibroblasts (FSF1) in culture. ND and SiO2-NP at low concentration (up to 0.5 μg/ml) had beneficial effects on FSF1 in terms of increasing their proliferation and metabolic activity. Exposure of FSF1 cells to low levels of NP enhanced their wound healing ability in vitro and slowed down aging during serial passaging as measured by maintenance of youthful morphology, reduction in the rate of loss of telomeres, and the over all proliferative characterisitics. Furthermore, NP treatment induced the activation of Nrf2- and FOXO3A mediated cellular stress responses, including an increased expression of heme oxygenease HO-1), sirtuin (SIRT1), and DNA methyltransferase II (DNMT2). These results imply that ND and SiO2-NP at low doses are potential hormetins, which exert mild stress-induced beneficial hormetic effects through improved survival, longevity, maintenance, repair andfunction of human cells

KW - nanoparticle, stress, hormesis, ageing, anti-ageing, longevity, health

U2 - 10.1016/j.chemosphere.2016.01.045

DO - 10.1016/j.chemosphere.2016.01.045

M3 - Journal article

VL - 148

SP - 307

EP - 315

JO - Chemosphere

JF - Chemosphere

SN - 0045-6535

IS - 1

ER -