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Loss of consciousness reduces the stability of brain hubs and the heterogeneity of brain dynamics

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Standard

Loss of consciousness reduces the stability of brain hubs and the heterogeneity of brain dynamics. / López-González, Ane; Panda, Rajanikant; Ponce-Alvarez, Adrián; Zamora-López, Gorka; Escrichs, Anira; Martial, Charlotte; Thibaut, Aurore; Gosseries, Olivia; Kringelbach, Morten L.; Annen, Jitka; Laureys, Steven; Deco, Gustavo.

I: Communications Biology, Bind 4, Nr. 1, 1037, 12.2021.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

López-González, A, Panda, R, Ponce-Alvarez, A, Zamora-López, G, Escrichs, A, Martial, C, Thibaut, A, Gosseries, O, Kringelbach, ML, Annen, J, Laureys, S & Deco, G 2021, 'Loss of consciousness reduces the stability of brain hubs and the heterogeneity of brain dynamics', Communications Biology, bind 4, nr. 1, 1037. https://doi.org/10.1038/s42003-021-02537-9

APA

López-González, A., Panda, R., Ponce-Alvarez, A., Zamora-López, G., Escrichs, A., Martial, C., Thibaut, A., Gosseries, O., Kringelbach, M. L., Annen, J., Laureys, S., & Deco, G. (2021). Loss of consciousness reduces the stability of brain hubs and the heterogeneity of brain dynamics. Communications Biology, 4(1), [1037]. https://doi.org/10.1038/s42003-021-02537-9

CBE

López-González A, Panda R, Ponce-Alvarez A, Zamora-López G, Escrichs A, Martial C, Thibaut A, Gosseries O, Kringelbach ML, Annen J, Laureys S, Deco G. 2021. Loss of consciousness reduces the stability of brain hubs and the heterogeneity of brain dynamics. Communications Biology. 4(1):Article 1037. https://doi.org/10.1038/s42003-021-02537-9

MLA

Vancouver

López-González A, Panda R, Ponce-Alvarez A, Zamora-López G, Escrichs A, Martial C o.a. Loss of consciousness reduces the stability of brain hubs and the heterogeneity of brain dynamics. Communications Biology. 2021 dec;4(1). 1037. https://doi.org/10.1038/s42003-021-02537-9

Author

López-González, Ane ; Panda, Rajanikant ; Ponce-Alvarez, Adrián ; Zamora-López, Gorka ; Escrichs, Anira ; Martial, Charlotte ; Thibaut, Aurore ; Gosseries, Olivia ; Kringelbach, Morten L. ; Annen, Jitka ; Laureys, Steven ; Deco, Gustavo. / Loss of consciousness reduces the stability of brain hubs and the heterogeneity of brain dynamics. I: Communications Biology. 2021 ; Bind 4, Nr. 1.

Bibtex

@article{2d5c2f5cb69f43dd9d25e2069319612e,
title = "Loss of consciousness reduces the stability of brain hubs and the heterogeneity of brain dynamics",
abstract = "Low-level states of consciousness are characterized by disruptions of brain activity that sustain arousal and awareness. Yet, how structural, dynamical, local and network brain properties interplay in the different levels of consciousness is unknown. Here, we study fMRI brain dynamics from patients that suffered brain injuries leading to a disorder of consciousness and from healthy subjects undergoing propofol-induced sedation. We show that pathological and pharmacological low-level states of consciousness display less recurrent, less connected and more segregated synchronization patterns than conscious state. We use whole-brain models built upon healthy and injured structural connectivity to interpret these dynamical effects. We found that low-level states of consciousness were associated with reduced network interactions, together with more homogeneous and more structurally constrained local dynamics. Notably, these changes lead the structural hub regions to lose their stability during low-level states of consciousness, thus attenuating the differences between hubs and non-hubs brain dynamics.",
author = "Ane L{\'o}pez-Gonz{\'a}lez and Rajanikant Panda and Adri{\'a}n Ponce-Alvarez and Gorka Zamora-L{\'o}pez and Anira Escrichs and Charlotte Martial and Aurore Thibaut and Olivia Gosseries and Kringelbach, {Morten L.} and Jitka Annen and Steven Laureys and Gustavo Deco",
note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",
year = "2021",
month = dec,
doi = "10.1038/s42003-021-02537-9",
language = "English",
volume = "4",
journal = "Communications Biology",
issn = "2399-3642",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Loss of consciousness reduces the stability of brain hubs and the heterogeneity of brain dynamics

AU - López-González, Ane

AU - Panda, Rajanikant

AU - Ponce-Alvarez, Adrián

AU - Zamora-López, Gorka

AU - Escrichs, Anira

AU - Martial, Charlotte

AU - Thibaut, Aurore

AU - Gosseries, Olivia

AU - Kringelbach, Morten L.

AU - Annen, Jitka

AU - Laureys, Steven

AU - Deco, Gustavo

N1 - Publisher Copyright: © 2021, The Author(s).

PY - 2021/12

Y1 - 2021/12

N2 - Low-level states of consciousness are characterized by disruptions of brain activity that sustain arousal and awareness. Yet, how structural, dynamical, local and network brain properties interplay in the different levels of consciousness is unknown. Here, we study fMRI brain dynamics from patients that suffered brain injuries leading to a disorder of consciousness and from healthy subjects undergoing propofol-induced sedation. We show that pathological and pharmacological low-level states of consciousness display less recurrent, less connected and more segregated synchronization patterns than conscious state. We use whole-brain models built upon healthy and injured structural connectivity to interpret these dynamical effects. We found that low-level states of consciousness were associated with reduced network interactions, together with more homogeneous and more structurally constrained local dynamics. Notably, these changes lead the structural hub regions to lose their stability during low-level states of consciousness, thus attenuating the differences between hubs and non-hubs brain dynamics.

AB - Low-level states of consciousness are characterized by disruptions of brain activity that sustain arousal and awareness. Yet, how structural, dynamical, local and network brain properties interplay in the different levels of consciousness is unknown. Here, we study fMRI brain dynamics from patients that suffered brain injuries leading to a disorder of consciousness and from healthy subjects undergoing propofol-induced sedation. We show that pathological and pharmacological low-level states of consciousness display less recurrent, less connected and more segregated synchronization patterns than conscious state. We use whole-brain models built upon healthy and injured structural connectivity to interpret these dynamical effects. We found that low-level states of consciousness were associated with reduced network interactions, together with more homogeneous and more structurally constrained local dynamics. Notably, these changes lead the structural hub regions to lose their stability during low-level states of consciousness, thus attenuating the differences between hubs and non-hubs brain dynamics.

UR - http://www.scopus.com/inward/record.url?scp=85114610639&partnerID=8YFLogxK

U2 - 10.1038/s42003-021-02537-9

DO - 10.1038/s42003-021-02537-9

M3 - Journal article

C2 - 34489535

AN - SCOPUS:85114610639

VL - 4

JO - Communications Biology

JF - Communications Biology

SN - 2399-3642

IS - 1

M1 - 1037

ER -