Long-Term Exposure to Transportation Noise and Risk of Incident Stroke: A Pooled Study of Nine Scandinavian Cohorts

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  • Nina Roswall, Danish Cancer Society Research Centre, Danish Cancer Society, Copenhagen, Denmark., Danmark
  • Andrei Pyko, Center for Occupational and Environmental Medicine, Region Stockholm, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sverige
  • Mikael Ögren, Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sverige
  • Anna Oudin, Environment Society and Health, Lund University, Section of Sustainable Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sverige
  • Annika Rosengren, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sverige
  • Anton Lager, Centre for Epidemiology and Community Medicine, Stockholm County Council, Stockholm, Sweden., Department of Global Public Health, Karolinska Institutet, Stockholm, Sverige
  • Aslak H Poulsen, Danish Cancer Society Research Centre, Danish Cancer Society, Copenhagen, Denmark., Danmark
  • Charlotta Eriksson, Center for Occupational and Environmental Medicine, Region Stockholm, Institute of Environmental Medicine, Karolinska Institutet, Stockholm
  • ,
  • David Segersson, Swedish Meteorological and Hydrological Institute, Norrköping, Department of Environmental Science, Stockholm University, Sverige
  • Debora Rizzuto, Aging Research Center, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Stockholm University, The Stockholm Gerontology Research Center, Sverige
  • Eva M Andersson, Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital and Academy. Gothenburg, Sverige
  • Gunn Marit Aasvang, Norwegian Institute of Public Health, Norge
  • Gunnar Engström, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Sverige
  • Jeanette T Jørgensen, University of Copenhagen, Department of Public Health, Danmark
  • Jenny Selander, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sverige
  • Jesper H Christensen
  • Jesse Thacher, Danish Cancer Society Research Centre, Danish Cancer Society, Copenhagen, Denmark., Danmark
  • Karin Leander, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sverige
  • Kim Overvad
  • Kristina Eneroth, Environment and Health Administration, Sverige
  • Kristoffer Mattisson, Division of Occupational and Environmental Medicine, Lund University Hospital, SE 221 85 Lund, Sweden., Sverige
  • Lars Barregård, Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital and Academy. Gothenburg, Sverige
  • Leo Stockfelt, Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital and Academy. Gothenburg, Sverige
  • Maria Albin, Center for Occupational and Environmental Medicine, Region Stockholm, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Division of Occupational and Environmental Medicine, Lund University Hospital, SE 221 85 Lund, Sweden., Sverige
  • Matthias Ketzel
  • Mette K Simonsen, Department of Urology, Frederiksberg Hospital, Frederiksberg, Denmark., Danmark
  • Mårten Spanne, Environment Department, Research Center for Energy, Environment and Technology (CIEMAT), Sverige
  • Ole Raaschou-Nielsen
  • Patrik K E Magnusson, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Sverige
  • Pekka Tiittanen, Finnish Institute for Health and Welfare, Finland
  • Peter Molnar, Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital and Academy. Gothenburg, Sverige
  • Petter Ljungman, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Department of Cardiology, Danderyd University Hospital, Stockholm, Sverige
  • Timo Lanki, Finnish Institute for Health and Welfare, School of Medicine, University of Eastern Finland, Kuopio, Department of Environmental and Biological Sciences, University of Eastern Finland, Kuopio, Finland
  • Youn-Hee Lim, Department of Public Health, University of Copenhagen, Copenhagen, Denmark, Danmark
  • Zorana J Andersen, Department of Public Health, University of Copenhagen, Copenhagen, Denmark, Danmark
  • Göran Pershagen, Center for Occupational and Environmental Medicine, Region Stockholm, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sverige
  • Mette Sørensen, Danish Cancer Society Research Centre, Danish Cancer Society, Copenhagen, Denmark., Department of Natural Science and Environment, Danmark

BACKGROUND: Transportation noise is increasingly acknowledged as a cardiovascular risk factor, but the evidence base for an association with stroke is sparse.

OBJECTIVE: We aimed to investigate the association between transportation noise and stroke incidence in a large Scandinavian population.

METHODS: We harmonized and pooled data from nine Scandinavian cohorts (seven Swedish, two Danish), totaling 135,951 participants. We identified residential address history and estimated road, railway, and aircraft noise for all addresses. Information on stroke incidence was acquired through linkage to national patient and mortality registries. We analyzed data using Cox proportional hazards models, including socioeconomic and lifestyle confounders, and air pollution.

RESULTS: During follow-up (median=19.5y), 11,056 stroke cases were identified. Road traffic noise (Lden) was associated with risk of stroke, with a hazard ratio (HR) of 1.06 [95% confidence interval (CI): 1.03, 1.08] per 10-dB higher 5-y mean time-weighted exposure in analyses adjusted for individual- and area-level socioeconomic covariates. The association was approximately linear and persisted after adjustment for air pollution [particulate matter (PM) with an aerodynamic diameter of ≤2.5μm (PM2.5) and NO2]. Stroke was associated with moderate levels of 5-y aircraft noise exposure (40-50 vs. ≤40 dB) (HR=1.12; 95% CI: 0.99, 1.27), but not with higher exposure (≥50 dB, HR=0.94; 95% CI: 0.79, 1.11). Railway noise was not associated with stroke.

DISCUSSION: In this pooled study, road traffic noise was associated with a higher risk of stroke. This finding supports road traffic noise as an important cardiovascular risk factor that should be included when estimating the burden of disease due to traffic noise. https://doi.org/10.1289/EHP8949.

OriginalsprogEngelsk
Artikelnummer107002
TidsskriftEnvironmental Health Perspectives
Vol/bind129
Nummer10
Antal sider10
ISSN0091-6765
DOI
StatusUdgivet - okt. 2021

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