Long-Term Exposure to Transportation Noise and Ischemic Heart Disease: A Pooled Analysis of Nine Scandinavian Cohorts

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  • Andrei Pyko, Karolinska Institutet, Academic Primary Health Care Centre, Region Stockholm, Stockholm, Sweden, Sverige
  • Nina Roswall, Kræftens Bekæmpelse, Danmark
  • Mikael Ögren, University of Gothenburg, Sverige
  • Anna Oudin, Lund University, Umeå University, Sverige
  • Annika Rosengren, University of Gothenburg, Sverige
  • Charlotta Eriksson, Karolinska Institutet, Academic Primary Health Care Centre, Region Stockholm, Stockholm, Sweden, Sverige
  • David Segersson, Swedish Meteorological and Hydrological Institute, Stockholm University, Sverige
  • Debora Rizzuto, Karolinska Institutet, Stockholm University, The Stockholm Gerontology Research Center, Sverige
  • Eva M Andersson, University of Gothenburg, Sverige
  • Gunn Marit Aasvang, Norwegian Institute of Public Health, Norge
  • Gunnar Engström, Lund University, Sverige
  • Hrafnhildur Gudjonsdottir, Centre for Epidemiology and Community Medicine, Stockholm County Council, Stockholm, Sweden., Karolinska Institutet, Sverige
  • Jeanette T Jørgensen, Københavns Universitet, Danmark
  • Jenny Selander, Karolinska Institutet, Sverige
  • Jesper H Christensen
  • Jørgen Brandt
  • Karin Leander, Karolinska Institutet, Sverige
  • Kim Overvad
  • Kristina Eneroth, Environment and Health Administration, Sverige
  • Kristoffer Mattisson, Lund University, Sverige
  • Lars Barregard, University of Gothenburg, Sverige
  • Leo Stockfelt, University of Gothenburg, Sverige
  • Maria Albin, Karolinska Institutet, Academic Primary Health Care Centre, Region Stockholm, Stockholm, Sweden, Lund University, Sverige
  • Mette K Simonsen, Parker Instituttet, Frederiksberg Hospital
  • ,
  • Pekka Tiittanen, National Institute for Health and Welfare, Finland
  • Peter Molnar, University of Gothenburg, Sverige
  • Petter Ljungman, Karolinska Institutet, Department of Cardiology, Danderyd Hospital, Stockholm, Sweden., Sverige
  • Steen Solvang Jensen
  • Susanna Gustafsson, City of Malmö, Sverige
  • Timo Lanki, National Institute for Health and Welfare, University of Eastern Finland, Finland
  • Youn-Hee Lim, Københavns Universitet, Danmark
  • Zorana J Andersen, Københavns Universitet, Danmark
  • Mette Sørensen, Roskilde Universitet, Kræftens Bekæmpelse
  • ,
  • Göran Pershagen, Karolinska Institutet, Academic Primary Health Care Centre, Region Stockholm, Stockholm, Sweden, Sverige

BACKGROUND: Transportation noise may induce cardiovascular disease, but the public health implications are unclear.

OBJECTIVES: The study aimed to assess exposure-response relationships for different transportation noise sources and ischemic heart disease (IHD), including subtypes.

METHODS: Pooled analyses were performed of nine cohorts from Denmark and Sweden, together including 132,801 subjects. Time-weighted long-term exposure to road, railway, and aircraft noise, as well as air pollution, was estimated based on residential histories. Hazard ratios (HRs) were calculated using Cox proportional hazards models following adjustment for lifestyle and socioeconomic risk factors.

RESULTS: A total of 22,459 incident cases of IHD were identified during follow-up from national patient and mortality registers, including 7,682 cases of myocardial infarction. The adjusted HR for IHD was 1.03 [95% confidence interval (CI) 1.00, 1.05] per 10 dB L den for both road and railway noise exposure during 5 y prior to the event. Higher risks were indicated for IHD excluding angina pectoris cases, with HRs of 1.06 (95% CI: 1.03, 1.08) and 1.05 (95% CI: 1.01, 1.08) per 10 dB L den for road and railway noise, respectively. Corresponding HRs for myocardial infarction were 1.02 (95% CI: 0.99, 1.05) and 1.04 (95% CI: 0.99, 1.08). Increased risks were observed for aircraft noise but without clear exposure-response relations. A threshold at around 55 dB L den was suggested in the exposure-response relation for road traffic noise and IHD.

DISCUSSION: Exposure to road, railway, and aircraft noise in the prior 5 y was associated with an increased risk of IHD, particularly after exclusion of angina pectoris cases, which are less well identified in the registries. https://doi.org/10.1289/EHP10745.

TidsskriftEnvironmental Health Perspectives
Antal sider11
StatusUdgivet - jan. 2023

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