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Long term exposure to air pollution and kidney parenchyma cancer – Effects of low-level air pollution: a Study in Europe (ELAPSE)

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

DOI

  • Ulla Arthur Hvidtfeldt, Kræftens Bekæmpelse
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  • Tahir Taj, Kræftens Bekæmpelse, Örebro Universitet
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  • Jie Chen, Utrecht University
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  • Sophia Rodopoulou, University of Athens
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  • Maciej Strak, Utrecht University, National Institute for Public Health and the Environment (RIVM)
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  • Kees de Hoogh, Swiss Tropical and Public Health Institute, University of Basel
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  • Zorana J. Andersen, Københavns Universitet
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  • Tom Bellander, Karolinska Institutet, Centre for Occupational and Environmental Medicine
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  • Jørgen Brandt
  • Daniela Fecht, MRC Centre for Environment and Health
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  • Francesco Forastiere, Lazio Regional Health Service, Imperial College London
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  • John Gulliver, MRC Centre for Environment and Health, University of Leicester
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  • Ole Hertel
  • Barbara Hoffmann, Heinrich Heine University Düsseldorf
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  • Jeanette T. Jørgensen, Københavns Universitet
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  • Klea Katsouyanni, University of Athens, MRC Centre for Environment and Health
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  • Matthias Ketzel
  • Anton Lager, Karolinska Institutet
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  • Karin Leander, Karolinska Institutet
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  • Petter Ljungman, Karolinska Institutet
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  • Patrik K.E. Magnusson, Karolinska Institutet
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  • Gabriele Nagel, Ulm University
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  • Göran Pershagen, Karolinska Institutet, Centre for Occupational and Environmental Medicine
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  • Debora Rizzuto, Karolinska Institutet, Karolinska Institutet and Stockholm University and The Stockholm Gerontology Research Center
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  • Evangelia Samoli, University of Athens
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  • Rina So, Københavns Universitet
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  • Massimo Stafoggia, Karolinska Institutet, Lazio Regional Health Service
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  • Anne Tjønneland, Kræftens Bekæmpelse
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  • Roel Vermeulen, Utrecht University
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  • Gudrun Weinmayr, Ulm University
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  • Kathrin Wolf, Helmholtz Zentrum München - German Research Center for Environmental Health
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  • Jiawei Zhang, Københavns Universitet
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  • Emanuel Zitt, LKH Feldkirch, Agency for Preventive and Social Medicine, Bregenz, Austria.
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  • Bert Brunekreef, Utrecht University
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  • Gerard Hoek, Utrecht University
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  • Ole Raaschou-Nielsen

BACKGROUND: Particulate matter (PM) is classified as a group 1 human carcinogen. Previous experimental studies suggest that particles in diesel exhaust induce oxidative stress, inflammation and DNA damage in kidney cells, but the evidence from population studies linking air pollution to kidney cancer is limited. METHODS: We pooled six European cohorts (N = 302,493) to assess the association of residential exposure to fine particles (PM2.5), nitrogen dioxide (NO2), black carbon (BC), warm season ozone (O3) and eight elemental components of PM2.5 (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) with cancer of the kidney parenchyma. The main exposure model was developed for year 2010. We defined kidney parenchyma cancer according to the International Classification of Diseases 9th and 10th Revision codes 189.0 and C64. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. RESULTS: The participants were followed from baseline (1985–2005) to 2011–2015. A total of 847 cases occurred during 5,497,514 person-years of follow-up (average 18.2 years). Median (5–95%) exposure levels of NO2, PM2.5, BC and O3 were 24.1 μg/m3 (12.8–39.2), 15.3 μg/m3 (8.6–19.2), 1.6 10−5 m−1 (0.7–2.1), and 87.0 μg/m3 (70.3–97.4), respectively. The results of the fully adjusted linear analyses showed a hazard ratio (HR) of 1.03 (95% confidence interval [CI]: 0.92, 1.15) per 10 μg/m³ NO2, 1.04 (95% CI: 0.88, 1.21) per 5 μg/m³ PM2.5, 0.99 (95% CI: 0.89, 1.11) per 0.5 10−5 m−1 BCE, and 0.88 (95% CI: 0.76, 1.02) per 10 μg/m³ O3. We did not find associations between any of the elemental components of PM2.5 and cancer of the kidney parenchyma. CONCLUSION: We did not observe an association between long-term ambient air pollution exposure and incidence of kidney parenchyma cancer.

OriginalsprogEngelsk
Artikelnummer114385
TidsskriftEnvironmental Research
Vol/bind215
ISSN0013-9351
DOI
StatusUdgivet - dec. 2022

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