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Long non-coding RNAs guide the fine-tuning of gene regulation in B-cell development and malignancy

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Long non-coding RNAs guide the fine-tuning of gene regulation in B-cell development and malignancy. / Dahl, Mette; Kristensen, Lasse Sommer; Grønbæk, Kirsten.

I: International Journal of Molecular Sciences, Bind 19, Nr. 9, 2475, 01.09.2018.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

Harvard

Dahl, M, Kristensen, LS & Grønbæk, K 2018, 'Long non-coding RNAs guide the fine-tuning of gene regulation in B-cell development and malignancy', International Journal of Molecular Sciences, bind 19, nr. 9, 2475. https://doi.org/10.3390/ijms19092475

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Author

Dahl, Mette ; Kristensen, Lasse Sommer ; Grønbæk, Kirsten. / Long non-coding RNAs guide the fine-tuning of gene regulation in B-cell development and malignancy. I: International Journal of Molecular Sciences. 2018 ; Bind 19, Nr. 9.

Bibtex

@article{c720442a14684c82addea2f9cd335c17,
title = "Long non-coding RNAs guide the fine-tuning of gene regulation in B-cell development and malignancy",
abstract = "With the introduction of next generation sequencing methods, such as RNA sequencing, it has become apparent that alterations in the non-coding regions of our genome are important in the development of cancer. Particularly interesting is the class of long non-coding RNAs (lncRNAs), including the recently described subclass of circular RNAs (circRNAs), which display tissue-and cell-type specific expression patterns and exert diverse regulatory functions in the cells. B-cells undergo complex and tightly regulated processes in order to develop from antigen na{\"i}ve cells residing in the bone marrow to the highly diverse and competent effector cells circulating in peripheral blood. These processes include V(D)J recombination, rapid proliferation, somatic hypermutation and clonal selection, posing a risk of malignant transformation at each step. The aim of this review is to provide insight into how lncRNAs including circRNAs, participate in normal B-cell differentiation, and how deregulation of these molecules is involved in the development of B-cell malignancies. We describe the prognostic value and functional significance of specific deregulated lncRNAs in diseases such as acute lymphoblastic leukemia, chronic lymphocytic leukemia, mantle cell lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, Burkitt lymphoma and multiple myeloma, and we provide an overview of the current knowledge on the role of circRNAs in these diseases.",
keywords = "Acute lymphoblastic leukemia (ALL), B-cell development, Burkitt lymphoma (BL), Chronic lymphocytic leukemia (CLL), Circular RNA, Diffuse large b-cell lymphoma (DLBCL), Gene regulation, Long non-coding RNA, Mantle cell lymphoma (MCL), Multiple myeloma (MM)",
author = "Mette Dahl and Kristensen, {Lasse Sommer} and Kirsten Gr{\o}nb{\ae}k",
year = "2018",
month = "9",
day = "1",
doi = "10.3390/ijms19092475",
language = "English",
volume = "19",
journal = "International Journal of Molecular Sciences (Online)",
issn = "1661-6596",
publisher = "MDPI AG",
number = "9",

}

RIS

TY - JOUR

T1 - Long non-coding RNAs guide the fine-tuning of gene regulation in B-cell development and malignancy

AU - Dahl, Mette

AU - Kristensen, Lasse Sommer

AU - Grønbæk, Kirsten

PY - 2018/9/1

Y1 - 2018/9/1

N2 - With the introduction of next generation sequencing methods, such as RNA sequencing, it has become apparent that alterations in the non-coding regions of our genome are important in the development of cancer. Particularly interesting is the class of long non-coding RNAs (lncRNAs), including the recently described subclass of circular RNAs (circRNAs), which display tissue-and cell-type specific expression patterns and exert diverse regulatory functions in the cells. B-cells undergo complex and tightly regulated processes in order to develop from antigen naïve cells residing in the bone marrow to the highly diverse and competent effector cells circulating in peripheral blood. These processes include V(D)J recombination, rapid proliferation, somatic hypermutation and clonal selection, posing a risk of malignant transformation at each step. The aim of this review is to provide insight into how lncRNAs including circRNAs, participate in normal B-cell differentiation, and how deregulation of these molecules is involved in the development of B-cell malignancies. We describe the prognostic value and functional significance of specific deregulated lncRNAs in diseases such as acute lymphoblastic leukemia, chronic lymphocytic leukemia, mantle cell lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, Burkitt lymphoma and multiple myeloma, and we provide an overview of the current knowledge on the role of circRNAs in these diseases.

AB - With the introduction of next generation sequencing methods, such as RNA sequencing, it has become apparent that alterations in the non-coding regions of our genome are important in the development of cancer. Particularly interesting is the class of long non-coding RNAs (lncRNAs), including the recently described subclass of circular RNAs (circRNAs), which display tissue-and cell-type specific expression patterns and exert diverse regulatory functions in the cells. B-cells undergo complex and tightly regulated processes in order to develop from antigen naïve cells residing in the bone marrow to the highly diverse and competent effector cells circulating in peripheral blood. These processes include V(D)J recombination, rapid proliferation, somatic hypermutation and clonal selection, posing a risk of malignant transformation at each step. The aim of this review is to provide insight into how lncRNAs including circRNAs, participate in normal B-cell differentiation, and how deregulation of these molecules is involved in the development of B-cell malignancies. We describe the prognostic value and functional significance of specific deregulated lncRNAs in diseases such as acute lymphoblastic leukemia, chronic lymphocytic leukemia, mantle cell lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, Burkitt lymphoma and multiple myeloma, and we provide an overview of the current knowledge on the role of circRNAs in these diseases.

KW - Acute lymphoblastic leukemia (ALL)

KW - B-cell development

KW - Burkitt lymphoma (BL)

KW - Chronic lymphocytic leukemia (CLL)

KW - Circular RNA

KW - Diffuse large b-cell lymphoma (DLBCL)

KW - Gene regulation

KW - Long non-coding RNA

KW - Mantle cell lymphoma (MCL)

KW - Multiple myeloma (MM)

UR - http://www.scopus.com/inward/record.url?scp=85052517125&partnerID=8YFLogxK

U2 - 10.3390/ijms19092475

DO - 10.3390/ijms19092475

M3 - Review

VL - 19

JO - International Journal of Molecular Sciences (Online)

JF - International Journal of Molecular Sciences (Online)

SN - 1661-6596

IS - 9

M1 - 2475

ER -