Logistics of neuronal protein turnover: Numbers and mechanisms

TY - JOUR

T1 - Logistics of neuronal protein turnover

T2 - Numbers and mechanisms

AU - Sun, Chao

AU - Schuman, Erin M

N1 - Copyright © 2022 Elsevier Inc. All rights reserved.

PY - 2022/12

Y1 - 2022/12

N2 - Research in the past twenty years or so has revealed that neurons synthesize and degrade proteins at their synapses to enable synaptic proteome remodelling on demand and in real-time. Here we provide a quantitative overview of the decentralized neuronal protein-turnover logistics. We first analyse the huge neuronal protein turnover demand that arises from subcellular compartments outside the cell body, followed by an overview of key quantities and modulation strategies in neuronal protein turnover logistics. In the end, we briefly review recent progress in neuronal local protein synthesis and summarize diverse protein-degradation mechanisms that are found near synapses.

AB - Research in the past twenty years or so has revealed that neurons synthesize and degrade proteins at their synapses to enable synaptic proteome remodelling on demand and in real-time. Here we provide a quantitative overview of the decentralized neuronal protein-turnover logistics. We first analyse the huge neuronal protein turnover demand that arises from subcellular compartments outside the cell body, followed by an overview of key quantities and modulation strategies in neuronal protein turnover logistics. In the end, we briefly review recent progress in neuronal local protein synthesis and summarize diverse protein-degradation mechanisms that are found near synapses.

KW - Neurons

KW - Proteolysis

KW - Proteome

KW - Synapses

UR - http://www.scopus.com/inward/record.url?scp=85142195361&partnerID=8YFLogxK

U2 - 10.1016/j.mcn.2022.103793

DO - 10.1016/j.mcn.2022.103793

M3 - Review

C2 - 36396040

SN - 1044-7431

VL - 123

SP - 103793

JO - Molecular and Cellular Neuroscience

JF - Molecular and Cellular Neuroscience

M1 - 103793

ER -