Lipoxygenase products in experimental septic arthritis in dogs

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  • T. Herlin
  • K. Fogh
  • V. E. Knudsen
  • ,
  • E. S. Hansen
  • ,
  • E. Bunger, Aarhus Universitet
  • ,
  • H. Ewald
  • ,
  • I. Holm
  • ,
  • K. Kragballe

Induction of an experimental septic arthritis was performed in the juvenile dog knee by an intra-articular injection with staphylococcus aureus. From plasma, lipoxygenase (LO) products arachidonic acid were separated by reversed-phase high-performance liquid chromatography (RP-HPLC) after extraction of lipids. The plasma samples did not contain UV-detectable amounts of LO products other than the LTB4 metabolite 20-COOH-LTB4, and 12-HETE. Small amounts of chemokinetically active material were found coeluting with the elute fraction of 20-COOH-LTB4 and 12-HETE after RP-HPLC. After 48 hours of septic arthritis, resulting in a massive acute joint inflammation, no significant changes in LO products were observed.

OriginalsprogEngelsk
BogserieAPMIS
Vol/bind96
Nummer7
Sider (fra-til)596-600
Antal sider5
ISSN0903-4641
DOI
StatusUdgivet - 1 jan. 1988

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