Lifestyle changes in middle age and risk of cancer: evidence from the European Prospective Investigation into Cancer and Nutrition

Edoardo Botteri, Giulia Peveri, Paula Berstad, Vincenzo Bagnardi, Geir Hoff, Alicia K. Heath, Amanda J. Cross, Paolo Vineis, Laure Dossus, Mattias Johansson, Heinz Freisling, Komodo Matta, Inge Huybrechts, Sairah L.F. Chen, Kristin B. Borch, Torkjel M. Sandanger, Therese H. Nøst, Christina C. Dahm, Christian S. Antoniussen, Sandar Tin TinAgnès Fournier, Chloé Marques, Fanny Artaud, Maria José Sánchez, Marcela Guevara, Carmen Santiuste, Antonio Agudo, Rashmita Bajracharya, Verena Katzke, Fulvio Ricceri, Claudia Agnoli, Manuela M. Bergmann, Matthias B. Schulze, Salvatore Panico, Giovanna Masala, Anne Tjønneland, Anja Olsen, Tanja Stocks, Jonas Manjer, Amaia Aizpurua-Atxega, Elisabete Weiderpass, Elio Riboli, Marc J. Gunter, Pietro Ferrari*

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Abstract

In this study, we aimed to provide novel evidence on the impact of changing lifestyle habits on cancer risk. In the EPIC cohort, 295,865 middle-aged participants returned a lifestyle questionnaire at baseline and during follow-up. At both timepoints, we calculated a healthy lifestyle index (HLI) score based on cigarette smoking, alcohol consumption, body mass index and physical activity. HLI ranged from 0 (most unfavourable) to 16 (most favourable). We estimated the association between HLI change and risk of lifestyle-related cancers—including cancer of the breast, lung, colorectum, stomach, liver, cervix, oesophagus, bladder, and others—using Cox regression models. We reported hazard ratios (HR) with 95% confidence intervals (CI). Median time between the two questionnaires was 5.7 years, median age at follow-up questionnaire was 59 years. After the follow-up questionnaire, we observed 14,933 lifestyle-related cancers over a median follow-up of 7.8 years. Each unit increase in the HLI score was associated with 4% lower risk of lifestyle-related cancers (HR 0.96; 95%CI 0.95–0.97). Among participants in the top HLI third at baseline (HLI > 11), those in the bottom third at follow-up (HLI ≤ 9) had 21% higher risk of lifestyle-related cancers (HR 1.21; 95%CI 1.07–1.37) than those remaining in the top third. Among participants in the bottom HLI third at baseline, those in the top third at follow-up had 25% lower risk of lifestyle-related cancers (HR 0.75; 95%CI 0.65–0.86) than those remaining in the bottom third. These results indicate that lifestyle changes in middle age may have a significant impact on cancer risk.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Epidemiology
Vol/bind39
Nummer2
Sider (fra-til)147-159
Antal sider13
ISSN0393-2990
DOI
StatusUdgivet - feb. 2024

Fingeraftryk

Dyk ned i forskningsemnerne om 'Lifestyle changes in middle age and risk of cancer: evidence from the European Prospective Investigation into Cancer and Nutrition'. Sammen danner de et unikt fingeraftryk.

Citationsformater