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Leaf gel from several Aloe species shows anti-inflammatory properties through the inhibition of lipopolysaccharide (LPS) mediated activation of Toll-like receptor 4 (TLR4) signaling

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  • Louise Isager Ahl, Københavns Universitet
  • ,
  • Mia Prehn Schoeneburg, Københavns Universitet
  • ,
  • Lisa Harth, Københavns Universitet
  • ,
  • Christopher J Barnes
  • Anders Woetmann, Københavns Universitet
  • ,
  • Nina Rønsted, Københavns Universitet, National Tropical Botanical Garden

Background: Gel extracted from the succulent inner leaf mesophyll of species from the plant genus Aloe have been used in traditional medicine for centuries as a topical treatment for a wide range of skin conditions. Aim of the study: The aim of this study was to investigate the potential anti-inflammatory properties of leaf gel from 23 different Aloe species. In this study we have focused on the pathways activated by the toll-like receptors TLR4 (activated by LPS), and TLR2/TLR6 (activated by FSL-1) by measuring transcriptional activity of NF-κB. Materials and methods: Gel extractions from the inner leaf mesophyll material of 23 different Aloe species, pure acemannan obtained from Aloe vera, and pH. Eur. reference material from Aloe vera and Aloe ferox, were tested on the cell line J774-Dual. NF-κB activity was measured after 24 h. Results: We found that 8 out of the 23 tested Aloe gel extracts significantly decreased LPS-induced NF-κB-activity, but no significant effect was seen with FSL-1. Conclusion: Based on these findings we can confirm that extracted gel from some of the tested Aloe species but not all, have anti-inflammatory properties.

TidsskriftPhytomedicine Plus
Antal sider1
StatusUdgivet - feb. 2023
Eksternt udgivetJa

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