Large-scale Investigation of the Parameters in Response to Eimeria maxima Challenge in Broilers

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Large-scale Investigation of the Parameters in Response to Eimeria maxima Challenge in Broilers. / Hamzic, Edin; Bed'hom, Bertrand; Juin, Herve; Hawken, Rachel; Abrahamsen, Mitchell S; Elsen, Jean-Michel; Servin, Bertrand; Pinard-van der Laan, Marie-Hélène; Demeure, Olivier.

I: Journal of Animal Science, Bind 93, Nr. 4, 01.05.2015, s. 1830-1840.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Hamzic, E, Bed'hom, B, Juin, H, Hawken, R, Abrahamsen, MS, Elsen, J-M, Servin, B, Pinard-van der Laan, M-H & Demeure, O 2015, 'Large-scale Investigation of the Parameters in Response to Eimeria maxima Challenge in Broilers', Journal of Animal Science, bind 93, nr. 4, s. 1830-1840.

APA

Hamzic, E., Bed'hom, B., Juin, H., Hawken, R., Abrahamsen, M. S., Elsen, J-M., ... Demeure, O. (2015). Large-scale Investigation of the Parameters in Response to Eimeria maxima Challenge in Broilers. Journal of Animal Science, 93(4), 1830-1840.

CBE

Hamzic E, Bed'hom B, Juin H, Hawken R, Abrahamsen MS, Elsen J-M, Servin B, Pinard-van der Laan M-H, Demeure O. 2015. Large-scale Investigation of the Parameters in Response to Eimeria maxima Challenge in Broilers. Journal of Animal Science. 93(4):1830-1840.

MLA

Hamzic, Edin o.a.. "Large-scale Investigation of the Parameters in Response to Eimeria maxima Challenge in Broilers". Journal of Animal Science. 2015, 93(4). 1830-1840.

Vancouver

Hamzic E, Bed'hom B, Juin H, Hawken R, Abrahamsen MS, Elsen J-M o.a. Large-scale Investigation of the Parameters in Response to Eimeria maxima Challenge in Broilers. Journal of Animal Science. 2015 maj 1;93(4):1830-1840.

Author

Hamzic, Edin ; Bed'hom, Bertrand ; Juin, Herve ; Hawken, Rachel ; Abrahamsen, Mitchell S ; Elsen, Jean-Michel ; Servin, Bertrand ; Pinard-van der Laan, Marie-Hélène ; Demeure, Olivier. / Large-scale Investigation of the Parameters in Response to Eimeria maxima Challenge in Broilers. I: Journal of Animal Science. 2015 ; Bind 93, Nr. 4. s. 1830-1840.

Bibtex

@article{b7a01251643e4f139acf391dc9e6b1c6,
title = "Large-scale Investigation of the Parameters in Response to Eimeria maxima Challenge in Broilers",
abstract = "Coccidiosis, a parasitic disease of the intestinal tract caused by members of the genera Eimeria and Isospora, is one of the most common and costly diseases in chicken. The aims of this study were to assess the effect of the challenge and level of variability of measured parameters in chickens during the challenge with Eimeria maxima. Furthermore, this study aimed to investigate which parameters are the most relevant indicators of the health status. Finally, the study also aimed to estimate accuracy of prediction for traits that cannot be measured on large scale (such as intestinal lesion score and fecal oocyst count) using parameters that can easily be measured on all animals. The study was performed in two parts: a pilot challenge on 240 animals, followed by a large-scale challenge on 2,024 animals. In both experiments, animals were challenged with 50,000 Eimeria maxima oocysts at 16 days of age. In the pilot challenge all animals were measured for BW gain, plasma coloration, hematocrit and rectal temperature and in addition a subset of 48 animals was measured for oocyst count and the intestinal lesion score. All animals from the second challenge were measured for BW gain, plasma coloration and hematocrit whereas a subset of 184 animals were measured for intestinal lesion scores, fecal oocyst count, blood parameters, plasma protein content and composition. Most of the parameters measured were significantly affected by the challenge. Lesion scores for duodenum and jejunum (P <0.001), oocyst count (P <0.05), plasma coloration for the optical density values between 450 and 490 nm (P <0.001), albumin (P <0.001), $1-globulin (P <0.01), $2-globulin (P <0.001), $3-globulin (P <0.01) and $2-globulin (P <0.001) were the most strongly affected parameters and expressed the greatest levels of variation. Plasma protein profiles proved to be a new, reliable parameter for measuring response to Eimeria maxima. Prediction of intestinal lesion score and fecal oocyst count using the other parameters measured was not very precise (R2 <0.7). The study was successfully performed in real raising conditions on a large scale. Finally, we observed a high variability in response to the challenge, suggesting that broilers’ response to Eimeria maxima has a strong genetic determinism which may be improved by genetic selection.",
keywords = "large-scale study, broilers, disease indicators, Eimeria maxima",
author = "Edin Hamzic and Bertrand Bed'hom and Herve Juin and Rachel Hawken and Abrahamsen, {Mitchell S} and Jean-Michel Elsen and Bertrand Servin and {Pinard-van der Laan}, Marie-H{\'e}l{\`e}ne and Olivier Demeure",
year = "2015",
month = "5",
day = "1",
language = "English",
volume = "93",
pages = "1830--1840",
journal = "Journal of Animal Science",
issn = "0021-8812",
publisher = "AMER SOC ANIMAL SCIENCE",
number = "4",

}

RIS

TY - JOUR

T1 - Large-scale Investigation of the Parameters in Response to Eimeria maxima Challenge in Broilers

AU - Hamzic, Edin

AU - Bed'hom, Bertrand

AU - Juin, Herve

AU - Hawken, Rachel

AU - Abrahamsen, Mitchell S

AU - Elsen, Jean-Michel

AU - Servin, Bertrand

AU - Pinard-van der Laan, Marie-Hélène

AU - Demeure, Olivier

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Coccidiosis, a parasitic disease of the intestinal tract caused by members of the genera Eimeria and Isospora, is one of the most common and costly diseases in chicken. The aims of this study were to assess the effect of the challenge and level of variability of measured parameters in chickens during the challenge with Eimeria maxima. Furthermore, this study aimed to investigate which parameters are the most relevant indicators of the health status. Finally, the study also aimed to estimate accuracy of prediction for traits that cannot be measured on large scale (such as intestinal lesion score and fecal oocyst count) using parameters that can easily be measured on all animals. The study was performed in two parts: a pilot challenge on 240 animals, followed by a large-scale challenge on 2,024 animals. In both experiments, animals were challenged with 50,000 Eimeria maxima oocysts at 16 days of age. In the pilot challenge all animals were measured for BW gain, plasma coloration, hematocrit and rectal temperature and in addition a subset of 48 animals was measured for oocyst count and the intestinal lesion score. All animals from the second challenge were measured for BW gain, plasma coloration and hematocrit whereas a subset of 184 animals were measured for intestinal lesion scores, fecal oocyst count, blood parameters, plasma protein content and composition. Most of the parameters measured were significantly affected by the challenge. Lesion scores for duodenum and jejunum (P <0.001), oocyst count (P <0.05), plasma coloration for the optical density values between 450 and 490 nm (P <0.001), albumin (P <0.001), $1-globulin (P <0.01), $2-globulin (P <0.001), $3-globulin (P <0.01) and $2-globulin (P <0.001) were the most strongly affected parameters and expressed the greatest levels of variation. Plasma protein profiles proved to be a new, reliable parameter for measuring response to Eimeria maxima. Prediction of intestinal lesion score and fecal oocyst count using the other parameters measured was not very precise (R2 <0.7). The study was successfully performed in real raising conditions on a large scale. Finally, we observed a high variability in response to the challenge, suggesting that broilers’ response to Eimeria maxima has a strong genetic determinism which may be improved by genetic selection.

AB - Coccidiosis, a parasitic disease of the intestinal tract caused by members of the genera Eimeria and Isospora, is one of the most common and costly diseases in chicken. The aims of this study were to assess the effect of the challenge and level of variability of measured parameters in chickens during the challenge with Eimeria maxima. Furthermore, this study aimed to investigate which parameters are the most relevant indicators of the health status. Finally, the study also aimed to estimate accuracy of prediction for traits that cannot be measured on large scale (such as intestinal lesion score and fecal oocyst count) using parameters that can easily be measured on all animals. The study was performed in two parts: a pilot challenge on 240 animals, followed by a large-scale challenge on 2,024 animals. In both experiments, animals were challenged with 50,000 Eimeria maxima oocysts at 16 days of age. In the pilot challenge all animals were measured for BW gain, plasma coloration, hematocrit and rectal temperature and in addition a subset of 48 animals was measured for oocyst count and the intestinal lesion score. All animals from the second challenge were measured for BW gain, plasma coloration and hematocrit whereas a subset of 184 animals were measured for intestinal lesion scores, fecal oocyst count, blood parameters, plasma protein content and composition. Most of the parameters measured were significantly affected by the challenge. Lesion scores for duodenum and jejunum (P <0.001), oocyst count (P <0.05), plasma coloration for the optical density values between 450 and 490 nm (P <0.001), albumin (P <0.001), $1-globulin (P <0.01), $2-globulin (P <0.001), $3-globulin (P <0.01) and $2-globulin (P <0.001) were the most strongly affected parameters and expressed the greatest levels of variation. Plasma protein profiles proved to be a new, reliable parameter for measuring response to Eimeria maxima. Prediction of intestinal lesion score and fecal oocyst count using the other parameters measured was not very precise (R2 <0.7). The study was successfully performed in real raising conditions on a large scale. Finally, we observed a high variability in response to the challenge, suggesting that broilers’ response to Eimeria maxima has a strong genetic determinism which may be improved by genetic selection.

KW - large-scale study

KW - broilers

KW - disease indicators

KW - Eimeria maxima

UR - https://dl.sciencesocieties.org/publications/jas/supplements/93/1830-supplement.pdf

M3 - Journal article

VL - 93

SP - 1830

EP - 1840

JO - Journal of Animal Science

JF - Journal of Animal Science

SN - 0021-8812

IS - 4

ER -