Large-scale production of extracellular vesicles: Report on the “massivEVs” ISEV workshop

Lucia Paolini; Marta Monguió-Tortajada; Marta Costa; Fabio Antenucci; Mario Barilani; Marta Clos-Sansalvador; André Cronemberger Andrade; Tom A. P. Driedonks; Sara Giancaterino; Stephanie M. Kronstadt; Rachel R. Mizenko; Muhammad Nawaz; Xabier Osteikoetxea; Carla Pereira; Surya Shrivastava; Anders Toftegaard Boysen; Simonides Immanuel van de Wakker; Martijn J. C. van Herwijnen; Xiaoqin Wang; Dionysios C. Watson; Mario Gimona; Maria Kaparakis-Liaskos; Konstantin Konstantinov; Sai Kiang Lim; Nicole Meisner-Kober; Michiel Stork; Peter Nejsum; Annalisa Radeghieri; Eva Rohde; Nicolas Touzet; Marca H. M. Wauben; Kenneth W. Witwer; Antonella Bongiovanni; Paolo Bergese

doi:10.1002/jex2.63

Large-scale production of extracellular vesicles: Report on the “massivEVs” ISEV workshop

Lucia Paolini, Marta Monguió-Tortajada, Marta Costa, Fabio Antenucci, Mario Barilani, Marta Clos-Sansalvador, André Cronemberger Andrade, Tom A. P. Driedonks, Sara Giancaterino, Stephanie M. Kronstadt, Rachel R. Mizenko, Muhammad Nawaz, Xabier Osteikoetxea, Carla Pereira, Surya Shrivastava, Anders Toftegaard Boysen, Simonides Immanuel van de Wakker, Martijn J. C. van Herwijnen, Xiaoqin Wang, Dionysios C. WatsonMario Gimona, Maria Kaparakis-Liaskos, Konstantin Konstantinov, Sai Kiang Lim, Nicole Meisner-Kober, Michiel Stork, Peter Nejsum, Annalisa Radeghieri, Eva Rohde, Nicolas Touzet, Marca H. M. Wauben, Kenneth W. Witwer, Antonella Bongiovanni, Paolo Bergese

Institut for Klinisk Medicin - Infektionssygdomme

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Abstract

Abstract Extracellular vesicles (EVs) large-scale production is a crucial point for the translation of EVs from discovery to application of EV-based products. In October 2021, the International Society for Extracellular Vesicles (ISEV), along with support by the FET-OPEN projects, ?The Extracellular Vesicle Foundry? (evFOUNDRY) and ?Extracellular vesicles from a natural source for tailor-made nanomaterials? (VES4US), organized a workshop entitled ?massivEVs? to discuss the potential challenges for translation of EV-based products. This report gives an overview of the topics discussed during ?massivEVs?, the most important points raised, and the points of consensus reached after discussion among academia and industry representatives. Overall, the review of the existing EV manufacturing, upscaling challenges and directions for their resolution highlighted in the workshop painted an optimistic future for the expanding EV field.

Originalsprog	Engelsk
Artikelnummer	e63
Tidsskrift	Journal of Extracellular Biology
Vol/bind	1
Nummer	10
Antal sider	12
ISSN	2768-2811
DOI	https://doi.org/10.1002/jex2.63
Status	Udgivet - 2022

Emneord

EV-based products
extracellular vesicles
ISEV workshop
large-scale production
manufacturing
processing
regulatory issues

Adgang til dokumentet

10.1002/jex2.63Licens: CC BY

https://zenodo.org/record/7251877/files/J%20of%20Extracellular%20Bio%20-%202022%20-%20Paolini%20-%20Large%E2%80%90scale%20production%20of%20extracellular%20vesicles%20Report%20on%20the%20massivEVs%20ISEV.pdfLicens: CC BY

Citationsformater

Paolini, L., Monguió-Tortajada, M., Costa, M., Antenucci, F., Barilani, M., Clos-Sansalvador, M., Andrade, A. C., Driedonks, T. A. P., Giancaterino, S., Kronstadt, S. M., Mizenko, R. R., Nawaz, M., Osteikoetxea, X., Pereira, C., Shrivastava, S., Boysen, A. T., van de Wakker, S. I., van Herwijnen, M. J. C., Wang, X., ... Bergese, P. (2022). Large-scale production of extracellular vesicles: Report on the “massivEVs” ISEV workshop. Journal of Extracellular Biology, 1(10), Artikel e63. https://doi.org/10.1002/jex2.63

@article{6a8684e1145243fab88ae1655cc73d85,

title = "Large-scale production of extracellular vesicles: Report on the “massivEVs” ISEV workshop",

abstract = "Abstract Extracellular vesicles (EVs) large-scale production is a crucial point for the translation of EVs from discovery to application of EV-based products. In October 2021, the International Society for Extracellular Vesicles (ISEV), along with support by the FET-OPEN projects, ?The Extracellular Vesicle Foundry? (evFOUNDRY) and ?Extracellular vesicles from a natural source for tailor-made nanomaterials? (VES4US), organized a workshop entitled ?massivEVs? to discuss the potential challenges for translation of EV-based products. This report gives an overview of the topics discussed during ?massivEVs?, the most important points raised, and the points of consensus reached after discussion among academia and industry representatives. Overall, the review of the existing EV manufacturing, upscaling challenges and directions for their resolution highlighted in the workshop painted an optimistic future for the expanding EV field.",

keywords = "EV-based products, extracellular vesicles, ISEV workshop, large-scale production, manufacturing, processing, regulatory issues",

author = "Lucia Paolini and Marta Mongui{\'o}-Tortajada and Marta Costa and Fabio Antenucci and Mario Barilani and Marta Clos-Sansalvador and Andrade, {Andr{\'e} Cronemberger} and Driedonks, {Tom A. P.} and Sara Giancaterino and Kronstadt, {Stephanie M.} and Mizenko, {Rachel R.} and Muhammad Nawaz and Xabier Osteikoetxea and Carla Pereira and Surya Shrivastava and Boysen, {Anders Toftegaard} and {van de Wakker}, {Simonides Immanuel} and {van Herwijnen}, {Martijn J. C.} and Xiaoqin Wang and Watson, {Dionysios C.} and Mario Gimona and Maria Kaparakis-Liaskos and Konstantin Konstantinov and Lim, {Sai Kiang} and Nicole Meisner-Kober and Michiel Stork and Peter Nejsum and Annalisa Radeghieri and Eva Rohde and Nicolas Touzet and Wauben, {Marca H. M.} and Witwer, {Kenneth W.} and Antonella Bongiovanni and Paolo Bergese",

year = "2022",

doi = "10.1002/jex2.63",

language = "English",

volume = "1",

journal = "Journal of Extracellular Biology",

issn = "2768-2811",

publisher = "John Wiley & Sons, Ltd",

number = "10",

}

Paolini, L, Monguió-Tortajada, M, Costa, M, Antenucci, F, Barilani, M, Clos-Sansalvador, M, Andrade, AC, Driedonks, TAP, Giancaterino, S, Kronstadt, SM, Mizenko, RR, Nawaz, M, Osteikoetxea, X, Pereira, C, Shrivastava, S, Boysen, AT, van de Wakker, SI, van Herwijnen, MJC, Wang, X, Watson, DC, Gimona, M, Kaparakis-Liaskos, M, Konstantinov, K, Lim, SK, Meisner-Kober, N, Stork, M, Nejsum, P, Radeghieri, A, Rohde, E, Touzet, N, Wauben, MHM, Witwer, KW, Bongiovanni, A & Bergese, P 2022, 'Large-scale production of extracellular vesicles: Report on the “massivEVs” ISEV workshop', Journal of Extracellular Biology, bind 1, nr. 10, e63. https://doi.org/10.1002/jex2.63

TY - JOUR

T1 - Large-scale production of extracellular vesicles

T2 - Report on the “massivEVs” ISEV workshop

AU - Paolini, Lucia

AU - Monguió-Tortajada, Marta

AU - Costa, Marta

AU - Antenucci, Fabio

AU - Barilani, Mario

AU - Clos-Sansalvador, Marta

AU - Andrade, André Cronemberger

AU - Driedonks, Tom A. P.

AU - Giancaterino, Sara

AU - Kronstadt, Stephanie M.

AU - Mizenko, Rachel R.

AU - Nawaz, Muhammad

AU - Osteikoetxea, Xabier

AU - Pereira, Carla

AU - Shrivastava, Surya

AU - Boysen, Anders Toftegaard

AU - van de Wakker, Simonides Immanuel

AU - van Herwijnen, Martijn J. C.

AU - Wang, Xiaoqin

AU - Watson, Dionysios C.

AU - Gimona, Mario

AU - Kaparakis-Liaskos, Maria

AU - Konstantinov, Konstantin

AU - Lim, Sai Kiang

AU - Meisner-Kober, Nicole

AU - Stork, Michiel

AU - Nejsum, Peter

AU - Radeghieri, Annalisa

AU - Rohde, Eva

AU - Touzet, Nicolas

AU - Wauben, Marca H. M.

AU - Witwer, Kenneth W.

AU - Bongiovanni, Antonella

AU - Bergese, Paolo

PY - 2022

Y1 - 2022

N2 - Abstract Extracellular vesicles (EVs) large-scale production is a crucial point for the translation of EVs from discovery to application of EV-based products. In October 2021, the International Society for Extracellular Vesicles (ISEV), along with support by the FET-OPEN projects, ?The Extracellular Vesicle Foundry? (evFOUNDRY) and ?Extracellular vesicles from a natural source for tailor-made nanomaterials? (VES4US), organized a workshop entitled ?massivEVs? to discuss the potential challenges for translation of EV-based products. This report gives an overview of the topics discussed during ?massivEVs?, the most important points raised, and the points of consensus reached after discussion among academia and industry representatives. Overall, the review of the existing EV manufacturing, upscaling challenges and directions for their resolution highlighted in the workshop painted an optimistic future for the expanding EV field.

AB - Abstract Extracellular vesicles (EVs) large-scale production is a crucial point for the translation of EVs from discovery to application of EV-based products. In October 2021, the International Society for Extracellular Vesicles (ISEV), along with support by the FET-OPEN projects, ?The Extracellular Vesicle Foundry? (evFOUNDRY) and ?Extracellular vesicles from a natural source for tailor-made nanomaterials? (VES4US), organized a workshop entitled ?massivEVs? to discuss the potential challenges for translation of EV-based products. This report gives an overview of the topics discussed during ?massivEVs?, the most important points raised, and the points of consensus reached after discussion among academia and industry representatives. Overall, the review of the existing EV manufacturing, upscaling challenges and directions for their resolution highlighted in the workshop painted an optimistic future for the expanding EV field.

KW - EV-based products

KW - extracellular vesicles

KW - ISEV workshop

KW - large-scale production

KW - manufacturing

KW - processing

KW - regulatory issues

U2 - 10.1002/jex2.63

DO - 10.1002/jex2.63

M3 - Journal article

SN - 2768-2811

VL - 1

JO - Journal of Extracellular Biology

JF - Journal of Extracellular Biology

IS - 10

M1 - e63

ER -