Abstract
PURPOSE
Bladder reservoir function in children with monosymptomatic nocturnal enuresis (MNE) is assessed by maximal voided volumes (MVV) registered on frequency-volume charts during daytime. Although a degree of association is evident, MVV does not necessarily reflect the nocturnal bladder reservoir function in MNE. We aimed to evaluate the nocturnal bladder reservoir function during the night in children with a normal MVV.
MATERIAL AND METHODS
Data from 239 children aged 5-15 treated for MNE in a tertiary referral centre was collected for a nested cohort study. Data from 99 children was excluded due to reduced MVV according to ICCS standardization and 34 were lost to follow-up. The remaining 106 were divided into two groups, based on whether they experienced wet nights with nocturnal urine production (NUP) below MVV.
RESULTS
82 % of the children with MNE and a normal bladder capacity experienced wet nights with NUP below their MVV. The mean proportion of wet nights with NUP below MVV was 49 % and below MVV expected for age (MVVAge) the proportion was 23 %. Desmopressin response was negatively correlated with proportion of wet nights with NUP below MVV. The children with an occurrence of wet nights with NUP below MVV above 40 % had 11 % response rate for desmopressin treatment. Furthermore these children shared higher maximal NUP on dry nights than minimal NUP on wet nights.
CONCLUSIONS
Most children with MNE and normal MVV during daytime experience wet nights with urine volumes well below their MVV and MVVAge, the latter could be viewed as isolated reduced nocturnal bladder reservoir function. This indicates bladder reservoir function abnormalities during sleep that is not assessed by day recordings. Physicians treating children with MNE should consider anticholinergic and combination treatment.
Bladder reservoir function in children with monosymptomatic nocturnal enuresis (MNE) is assessed by maximal voided volumes (MVV) registered on frequency-volume charts during daytime. Although a degree of association is evident, MVV does not necessarily reflect the nocturnal bladder reservoir function in MNE. We aimed to evaluate the nocturnal bladder reservoir function during the night in children with a normal MVV.
MATERIAL AND METHODS
Data from 239 children aged 5-15 treated for MNE in a tertiary referral centre was collected for a nested cohort study. Data from 99 children was excluded due to reduced MVV according to ICCS standardization and 34 were lost to follow-up. The remaining 106 were divided into two groups, based on whether they experienced wet nights with nocturnal urine production (NUP) below MVV.
RESULTS
82 % of the children with MNE and a normal bladder capacity experienced wet nights with NUP below their MVV. The mean proportion of wet nights with NUP below MVV was 49 % and below MVV expected for age (MVVAge) the proportion was 23 %. Desmopressin response was negatively correlated with proportion of wet nights with NUP below MVV. The children with an occurrence of wet nights with NUP below MVV above 40 % had 11 % response rate for desmopressin treatment. Furthermore these children shared higher maximal NUP on dry nights than minimal NUP on wet nights.
CONCLUSIONS
Most children with MNE and normal MVV during daytime experience wet nights with urine volumes well below their MVV and MVVAge, the latter could be viewed as isolated reduced nocturnal bladder reservoir function. This indicates bladder reservoir function abnormalities during sleep that is not assessed by day recordings. Physicians treating children with MNE should consider anticholinergic and combination treatment.
| Originalsprog | Engelsk |
|---|---|
| Publikationsdato | 14 okt. 2015 |
| Status | Udgivet - 14 okt. 2015 |
| Begivenhed | ESPU ICCS 2015 - Prague, Tjekkiet Varighed: 14 okt. 2015 → 17 okt. 2015 |
Konference
| Konference | ESPU ICCS 2015 |
|---|---|
| Land/Område | Tjekkiet |
| By | Prague |
| Periode | 14/10/2015 → 17/10/2015 |