Ion channels, transporters, and sensors interact with the acidic tumor microenvironment to modify cancer progression

Publikation: Bidrag til bog/antologi/rapport/proceedingBidrag til bog/antologiForskningpeer review

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Ion channels, transporters, and sensors interact with the acidic tumor microenvironment to modify cancer progression. / Boedtkjer, Ebbe.

From Malignant Transformation to Metastasis: Ion Transport in Tumor Biology. red. / Christian Stock; Luis A. Pardo. Bind 182 Springer, 2022. s. 39-84 (Reviews of Physiology, Biochemistry and Pharmacology).

Publikation: Bidrag til bog/antologi/rapport/proceedingBidrag til bog/antologiForskningpeer review

Harvard

Boedtkjer, E 2022, Ion channels, transporters, and sensors interact with the acidic tumor microenvironment to modify cancer progression. i C Stock & LA Pardo (red), From Malignant Transformation to Metastasis: Ion Transport in Tumor Biology. bind 182, Springer, Reviews of Physiology, Biochemistry and Pharmacology, s. 39-84. https://doi.org/10.1007/112_2021_63

APA

Boedtkjer, E. (2022). Ion channels, transporters, and sensors interact with the acidic tumor microenvironment to modify cancer progression. I C. Stock, & L. A. Pardo (red.), From Malignant Transformation to Metastasis: Ion Transport in Tumor Biology (Bind 182, s. 39-84). Springer. Reviews of Physiology, Biochemistry and Pharmacology https://doi.org/10.1007/112_2021_63

CBE

Boedtkjer E. 2022. Ion channels, transporters, and sensors interact with the acidic tumor microenvironment to modify cancer progression. Stock C, Pardo LA, red. I From Malignant Transformation to Metastasis: Ion Transport in Tumor Biology. Springer. s. 39-84. (Reviews of Physiology, Biochemistry and Pharmacology). https://doi.org/10.1007/112_2021_63

MLA

Boedtkjer, Ebbe "Ion channels, transporters, and sensors interact with the acidic tumor microenvironment to modify cancer progression". og Stock, Christian Pardo, Luis A. (red.). From Malignant Transformation to Metastasis: Ion Transport in Tumor Biology. Springer. (Reviews of Physiology, Biochemistry and Pharmacology). 2022, 39-84. https://doi.org/10.1007/112_2021_63

Vancouver

Boedtkjer E. Ion channels, transporters, and sensors interact with the acidic tumor microenvironment to modify cancer progression. I Stock C, Pardo LA, red., From Malignant Transformation to Metastasis: Ion Transport in Tumor Biology. Bind 182. Springer. 2022. s. 39-84. (Reviews of Physiology, Biochemistry and Pharmacology). https://doi.org/10.1007/112_2021_63

Author

Boedtkjer, Ebbe. / Ion channels, transporters, and sensors interact with the acidic tumor microenvironment to modify cancer progression. From Malignant Transformation to Metastasis: Ion Transport in Tumor Biology. red. / Christian Stock ; Luis A. Pardo. Bind 182 Springer, 2022. s. 39-84 (Reviews of Physiology, Biochemistry and Pharmacology).

Bibtex

@inbook{7a75fc6d83ea426b9e4ab43805708faa,
title = "Ion channels, transporters, and sensors interact with the acidic tumor microenvironment to modify cancer progression",
abstract = "Solid tumors, including breast carcinomas, are heterogeneous but typically characterized by elevated cellular turnover and metabolism, diffusion limitations based on the complex tumor architecture, and abnormal intra- and extracellular ion compositions particularly as regards acid-base equivalents. Carcinogenesis-related alterations in expression and function of ion channels and transporters, cellular energy levels, and organellar H + sequestration further modify the acid-base composition within tumors and influence cancer cell functions, including cell proliferation, migration, and survival. Cancer cells defend their cytosolic pH and HCO 3 - concentrations better than normal cells when challenged with the marked deviations in extracellular H +, HCO 3 -, and lactate concentrations typical of the tumor microenvironment. Ionic gradients determine the driving forces for ion transporters and channels and influence the membrane potential. Cancer and stromal cells also sense abnormal ion concentrations via intra- and extracellular receptors that modify cancer progression and prognosis. With emphasis on breast cancer, the current review first addresses the altered ion composition and the changes in expression and functional activity of ion channels and transporters in solid cancer tissue. It then discusses how ion channels, transporters, and cellular sensors under influence of the acidic tumor microenvironment shape cancer development and progression and affect the potential of cancer therapies. ",
author = "Ebbe Boedtkjer",
year = "2022",
doi = "10.1007/112_2021_63",
language = "English",
isbn = "978-3-030-99800-4",
volume = "182",
series = "Reviews of Physiology, Biochemistry and Pharmacology",
publisher = "Springer",
pages = "39--84",
editor = "Christian Stock and Pardo, {Luis A.}",
booktitle = "From Malignant Transformation to Metastasis",
address = "Netherlands",

}

RIS

TY - CHAP

T1 - Ion channels, transporters, and sensors interact with the acidic tumor microenvironment to modify cancer progression

AU - Boedtkjer, Ebbe

PY - 2022

Y1 - 2022

N2 - Solid tumors, including breast carcinomas, are heterogeneous but typically characterized by elevated cellular turnover and metabolism, diffusion limitations based on the complex tumor architecture, and abnormal intra- and extracellular ion compositions particularly as regards acid-base equivalents. Carcinogenesis-related alterations in expression and function of ion channels and transporters, cellular energy levels, and organellar H + sequestration further modify the acid-base composition within tumors and influence cancer cell functions, including cell proliferation, migration, and survival. Cancer cells defend their cytosolic pH and HCO 3 - concentrations better than normal cells when challenged with the marked deviations in extracellular H +, HCO 3 -, and lactate concentrations typical of the tumor microenvironment. Ionic gradients determine the driving forces for ion transporters and channels and influence the membrane potential. Cancer and stromal cells also sense abnormal ion concentrations via intra- and extracellular receptors that modify cancer progression and prognosis. With emphasis on breast cancer, the current review first addresses the altered ion composition and the changes in expression and functional activity of ion channels and transporters in solid cancer tissue. It then discusses how ion channels, transporters, and cellular sensors under influence of the acidic tumor microenvironment shape cancer development and progression and affect the potential of cancer therapies.

AB - Solid tumors, including breast carcinomas, are heterogeneous but typically characterized by elevated cellular turnover and metabolism, diffusion limitations based on the complex tumor architecture, and abnormal intra- and extracellular ion compositions particularly as regards acid-base equivalents. Carcinogenesis-related alterations in expression and function of ion channels and transporters, cellular energy levels, and organellar H + sequestration further modify the acid-base composition within tumors and influence cancer cell functions, including cell proliferation, migration, and survival. Cancer cells defend their cytosolic pH and HCO 3 - concentrations better than normal cells when challenged with the marked deviations in extracellular H +, HCO 3 -, and lactate concentrations typical of the tumor microenvironment. Ionic gradients determine the driving forces for ion transporters and channels and influence the membrane potential. Cancer and stromal cells also sense abnormal ion concentrations via intra- and extracellular receptors that modify cancer progression and prognosis. With emphasis on breast cancer, the current review first addresses the altered ion composition and the changes in expression and functional activity of ion channels and transporters in solid cancer tissue. It then discusses how ion channels, transporters, and cellular sensors under influence of the acidic tumor microenvironment shape cancer development and progression and affect the potential of cancer therapies.

U2 - 10.1007/112_2021_63

DO - 10.1007/112_2021_63

M3 - Book chapter

C2 - 34291319

SN - 978-3-030-99800-4

VL - 182

T3 - Reviews of Physiology, Biochemistry and Pharmacology

SP - 39

EP - 84

BT - From Malignant Transformation to Metastasis

A2 - Stock, Christian

A2 - Pardo, Luis A.

PB - Springer

ER -