Investigation of serum levels of sortilin in response to antidepressant treatment

Henriette Nørmølle Buttenschøn; Marit Nielsen; Simon Glerup; Ole Mors

doi:10.1017/neu.2017.13

Investigation of serum levels of sortilin in response to antidepressant treatment

Henriette Nørmølle Buttenschøn, Marit Nielsen, Simon Glerup, Ole Mors

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

7 Citationer (Scopus)

Abstract

BACKGROUND: The identification of biomarkers for depression is of great clinical relevance as the diagnosis is currently subjective. Recent research points towards sortilin as a potential biomarker for depression, and the aim of the current study was to investigate the serum sortilin level in response to antidepressant treatment.

METHODS: The study included 56 depressed individuals of which 41 responded to treatment. Depression scores and serum levels of sortilin were measured at baseline and after 12 weeks of antidepressant treatment. Statistical analyses were performed using Stata 13.

RESULTS: The depression score and response to treatment were not predicted by the sortilin level. Likewise, we observed no significant change in serum sortilin levels following 12 weeks of antidepressant treatment. Furthermore, no association between the serum sortilin level and depression score was observed.

CONCLUSION: The results do not point towards sortilin as a state-dependent biomarker.

Originalsprog	Engelsk
Tidsskrift	Acta Neuropsychiatrica
Vol/bind	30
Nummer	2
Sider (fra-til)	111-116
Antal sider	6
ISSN	0924-2708
DOI	https://doi.org/10.1017/neu.2017.13
Status	Udgivet - apr. 2018

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10.1017/neu.2017.13

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title = "Investigation of serum levels of sortilin in response to antidepressant treatment",

abstract = "BACKGROUND: The identification of biomarkers for depression is of great clinical relevance as the diagnosis is currently subjective. Recent research points towards sortilin as a potential biomarker for depression, and the aim of the current study was to investigate the serum sortilin level in response to antidepressant treatment.METHODS: The study included 56 depressed individuals of which 41 responded to treatment. Depression scores and serum levels of sortilin were measured at baseline and after 12 weeks of antidepressant treatment. Statistical analyses were performed using Stata 13.RESULTS: The depression score and response to treatment were not predicted by the sortilin level. Likewise, we observed no significant change in serum sortilin levels following 12 weeks of antidepressant treatment. Furthermore, no association between the serum sortilin level and depression score was observed.CONCLUSION: The results do not point towards sortilin as a state-dependent biomarker.",

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AU - Buttenschøn, Henriette Nørmølle

AU - Nielsen, Marit

AU - Glerup, Simon

AU - Mors, Ole

PY - 2018/4

Y1 - 2018/4

N2 - BACKGROUND: The identification of biomarkers for depression is of great clinical relevance as the diagnosis is currently subjective. Recent research points towards sortilin as a potential biomarker for depression, and the aim of the current study was to investigate the serum sortilin level in response to antidepressant treatment.METHODS: The study included 56 depressed individuals of which 41 responded to treatment. Depression scores and serum levels of sortilin were measured at baseline and after 12 weeks of antidepressant treatment. Statistical analyses were performed using Stata 13.RESULTS: The depression score and response to treatment were not predicted by the sortilin level. Likewise, we observed no significant change in serum sortilin levels following 12 weeks of antidepressant treatment. Furthermore, no association between the serum sortilin level and depression score was observed.CONCLUSION: The results do not point towards sortilin as a state-dependent biomarker.

AB - BACKGROUND: The identification of biomarkers for depression is of great clinical relevance as the diagnosis is currently subjective. Recent research points towards sortilin as a potential biomarker for depression, and the aim of the current study was to investigate the serum sortilin level in response to antidepressant treatment.METHODS: The study included 56 depressed individuals of which 41 responded to treatment. Depression scores and serum levels of sortilin were measured at baseline and after 12 weeks of antidepressant treatment. Statistical analyses were performed using Stata 13.RESULTS: The depression score and response to treatment were not predicted by the sortilin level. Likewise, we observed no significant change in serum sortilin levels following 12 weeks of antidepressant treatment. Furthermore, no association between the serum sortilin level and depression score was observed.CONCLUSION: The results do not point towards sortilin as a state-dependent biomarker.

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DO - 10.1017/neu.2017.13

M3 - Journal article

C2 - 28478778

SN - 0924-2708

VL - 30

SP - 111

EP - 116

JO - Acta Neuropsychiatrica

JF - Acta Neuropsychiatrica

IS - 2

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Investigation of serum levels of sortilin in response to antidepressant treatment

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