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Investigation of candidate regions influencing litter size in Danish landrace sows

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  • D Bjerre, Københavns Universitet, Danmark
  • T Mark, Danmark
  • P Sørensen
  • H F Proschowsky, Danmark
  • A Vernersen, Danmark
  • C B Jørgensen, Danmark
  • M Fredholm, Danmark
  • Biostatistik
  • Institut for Genetik og Bioteknologi
Selection for increased litter size has been one of the main objectives in Danish pig breeding since 1992. This selection has lead to an average increase of 0.30 piglets per litter per year for Landrace and Yorkshire sows, resulting in an average litter size of 15.3 live born piglets in 2007, with a standard deviation of 3.5 piglets. The objective of this study was to investigate differences in identity by state relationships and allele effects associated with litter size across 17 selected microsatellite marker positions on chromosomes 11, 13, and 15. For this purpose, 357 Danish Landrace sows with high and low breeding values for litter size were genotyped. An assignment test showed that 91 and 90 percent of the sows could be assigned correctly to the group of sows representing high and low estimated breeding values, respectively, based on genotype information. Allele effects were estimated separately for each marker using de-regressed breeding values and a linear model that include both a polygenic and an allele effect. The investigated region on chromosome 13 was found to have a higher average identity by state relationship compared to the other regions, indicating that selection has taken place in this region. This is supported by a relatively high average allele effect of microsatellite alleles in the region. In spite of the apparent relative high historical selection pressure on chromosome 13, fairly large variation in allele effects was observed, indicating that the markers within the region may be used for marker assisted selection. However, substantial variation in allele effects was observed for several markers on all three investigated chromosomes indicating that selection should preferably be based on several markers
OriginalsprogEngelsk
TidsskriftJournal of Animal Science
Vol/bind88
Sider (fra-til)1603-1609
Antal sider7
ISSN0021-8812
DOI
StatusUdgivet - 2010

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