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Investigating the potential disease-modifying and neuroprotective efficacy of exercise therapy early in the disease course of multiple sclerosis: The Early Multiple Sclerosis Exercise Study (EMSES)
Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
DOI
- https://doi.org/10.1177/13524585221079200
Forlagets udgivne version
- Morten Riemenschneider
- Lars G Hvid
- Steffen Ringgaard
- Mikkel Karl Emil Nygaard
- Simon Fristed Eskildsen
- Tobias Gaemelke
- Melinda Magyari, Københavns Universitet ,
- Henrik Boye Jensen, Syddansk Universitet ,
- Helle Hvilsted Nielsen, Syddansk Universitet ,
- Matthias Kant, Syddansk Universitet ,
- Masoud Falah ,
- Thor Petersen ,
- Egon Stenager, Syddansk Universitet ,
- Ulrik Dalgas
- Institut for Folkesundhed - Idræt
- Institut for Klinisk Medicin - MR Forskningscentret
- Institut for Klinisk Medicin - Center for Funktionelt Integrativ Neurovidenskab-SKS
- Institut for Klinisk Medicin - Center for Funktionelt Integrativ Neurovidenskab (CFIN)
- Institut for Klinisk Medicin - Regionshospital Holstebro
- Institut for Klinisk Medicin - Neurologi
BACKGROUND: Potential supplemental disease-modifying and neuroprotective treatment strategies are warranted in multiple sclerosis (MS). Exercise is a promising non-pharmacological approach, and an uninvestigated 'window of opportunity' exists early in the disease course.
OBJECTIVE: To investigate the effect of early exercise on relapse rate, global brain atrophy and secondary magnetic resonance imaging (MRI) outcomes.
METHODS: This randomized controlled trial ( n = 84, disease duration <2 years) included 48 weeks of supervised aerobic exercise or control condition. Population-based control data (Danish MS Registry) was included ( n = 850, disease duration <2 years). Relapse rates were obtained from medical records, and patients underwent structural and diffusion-kurtosis MRI at baseline, 24 and 48 weeks.
RESULTS: No between-group differences were observed for primary outcomes, relapse rate (incidence-rate-ratio exercise relative to control: (0.49 (0.15; 1.66), p = 0.25) and global brain atrophy rate (-0.04 (-0.48; 0.40)%, p = 0.87), or secondary measures of lesion load. Aerobic fitness increased in favour of the exercise group. Microstructural integrity was higher in four of eight a priori defined motor-related tracts and nuclei in the exercise group compared with the control (thalamus, corticospinal tract, globus pallidus, cingulate gyrus) at 48 weeks.
CONCLUSION: Early supervised aerobic exercise did not reduce relapse rate or global brain atrophy, but does positively affect the microstructural integrity of important motor-related tracts and nuclei.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Multiple sclerosis (Houndmills, Basingstoke, England) |
| Vol/bind | 28 |
| Nummer | 10 |
| Sider (fra-til) | 1620-1629 |
| Antal sider | 10 |
| ISSN | 1352-4585 |
| DOI | |
| Status | Udgivet - sep. 2022 |
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