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Investigating the causal relationship between neuroticism and depression via Mendelian Randomization
Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Letter › peer review
Links
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426667/pdf/nihms-1008461.pdf
Accepteret manuskript
DOI
- https://doi.org/10.1111/acps.13009
Forlagets udgivne version
- Doug Speed
- Gibran Hemani, University of Bristol ,
- Maria S Speed
- Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium ,
- Anders D Børglum
- Aarhus Institute of Advanced Studies
- Center for Bioinformatik (BiRC)
- Institut for Klinisk Medicin - Afdeling for Depression og Angst
- Institut for Biomedicin - Forskning og uddannelse, Øst
- DANDRITE
- Institut for Klinisk Medicin - NIDO | Center for Forskning og Uddannelse
- Institut for Klinisk Medicin - Translational Neuropsychiatry Unit
- Institut for Økonomi
- Center for Registerforskning - CIRRAU - Centre for Integrated Register-based Research
- Center for Registerforskning
Neuroticism is a heritable personality trait, characterized by negative emotions such as worrying, feelings of guilt, loneliness and being easily hurt. Increased levels of neuroticism are associated with poor mental health - development of depression in particular - but it remains uncertain whether this association represents a causal effect [1]. Here, we use Mendelian randomization (MR) to investigate whether neuroticism is a causal risk factor for development of depression. This article is protected by copyright. All rights reserved.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Acta Psychiatrica Scandinavica |
| Vol/bind | 139 |
| Nummer | 4 |
| Sider (fra-til) | 395-397 |
| Antal sider | 3 |
| ISSN | 0001-690X |
| DOI | |
| Status | Udgivet - 2019 |
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