Intrauterine nicotine exposure, birth weight, gestational age and the risk of infantile colic

Publikation: KonferencebidragPosterForskningpeer review


Preterm and growth restricted infants may have developmental delays or deviant organ function related to the central nervous system and the gastrointestinal tract. Since both organ systems are hypothesized to be involved in the pathogenesis of infantile colic, a condition characterized by excessive crying during the first months of life, impaired fetal growth and preterm birth may be risk factors for infantile colic.
To investigate the association between gestational age, birth weight, and infantile colic.
We used maternal interviews from the Danish National Birth Cohort (1996 to
2002) conducted at gestational week 17 and at six months post partum. We included 62 761 live-born singletons with complete information on birth weight, gestational age, and crying symptoms recorded at six months of age. Infantile colic was defined according to Wessel's modified criteria:
crying for more than three hours per day for more than three days per week.
A total of 2605 (4.2 %) infants were born preterm, 54 441 (86.7%) at term, and 5715 (9.1%) post-term. A total of 4353 (7.7%) infants fulfilled Wessel's modified criteria. The risk for infantile colic increased with lower gestational age and birth weight after adjustment for several possible confounders. The highest risk (odds ratio [95 % confidence
interval]) was observed for infants born before 32 complete gestational weeks (1.5 [1.0-2.2; p<0.05], reference: 40 gestational weeks) or with birth weight less than 2000 grams (1.7 [1.3-2.2], reference: 3500 - 3999 grams). Small for gestational age infants (birth weight below 10th
percentile) had higher risk for infantile colic in all gestational ages.
This was statistically significant for infants born between 37-41 complete gestational weeks (1.2 [1.1-1.3]).
We found an association between infantile colic, and gestational age and birth weight in a large cohort study. This indicates that the aetiology of infantile colic may be found in the prenatal time period.
Udgivelsesår20 aug. 2013
StatusUdgivet - 20 aug. 2013
BegivenhedEuropean Congress of Epidemiology (EUROEPI) 2013 - Aarhus, Danmark
Varighed: 10 aug. 201314 aug. 2013


KonferenceEuropean Congress of Epidemiology (EUROEPI) 2013


  • kolik

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