Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFα prevents radiation-induced fibrosis

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Interdisciplinary Nanoscience Center
  • Eksperimentel Klinisk Onkologi, Afdeling for
  • Molekylærbiologisk Institut
  • Molekylærbiologisk Institut
One of the most common and dose-limiting long-term adverse effects of radiation therapy is radiation-induced fibrosis (RIF), which is characterized by restricted tissue flexibility, reduced compliance or strictures, pain and in severe cases, ulceration and necrosis. Several strategies have been proposed to ameliorate RIF but presently no effective one is available. Recent studies have reported that tumor necrosis factor-α (TNFα) plays a role in fibrogenesis.
OriginalsprogEngelsk
TidsskriftRadiotherapy & Oncology
Vol/bind97
Nummer1
Sider (fra-til)143-8
Antal sider6
ISSN0167-8140
DOI
StatusUdgivet - 1 okt. 2010

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