Intersection between calcium signalling and epithelial-mesenchymal plasticity in the context of cancer

Ellen K. Janke, Silke B. Chalmers, Sarah J. Roberts-Thomson, Gregory R. Monteith*

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

Abstract

Epithelial-mesenchymal transition (EMT) is a form of cellular phenotypic plasticity and is considered a crucial step in the progression of many cancers. The calcium ion (Ca2+) acts as a ubiquitous second messenger and is implicated in many cellular processes, including cell death, migration, invasion and more recently EMT. Throughout this review, the complex interplay between Ca2+ signalling and EMT will be explored. An overview of the Ca2+ pathways that are remodelled as a consequence of EMT is provided and the role of Ca2+ signalling in regulating EMT and its significance is considered. Ca2+ signalling pathways may represent a therapeutic opportunity to regulate EMT. However, as will be described in this review, the complexity of these signalling pathways represents significant challenges that must be considered if Ca2+ signalling is to be manipulated with the aim of therapeutic intervention in cancer.

OriginalsprogEngelsk
Artikelnummer102741
TidsskriftCell Calcium
Vol/bind112
ISSN0143-4160
DOI
StatusUdgivet - jun. 2023

Fingeraftryk

Dyk ned i forskningsemnerne om 'Intersection between calcium signalling and epithelial-mesenchymal plasticity in the context of cancer'. Sammen danner de et unikt fingeraftryk.

Citationsformater