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International Validation of the EORTC QLQ-ANL27, a Field Study to Test the Anal Cancer-Specific Health-Related Quality of Life Questionnaire

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

DOI

  • Samantha C Sodergren, University of Southampton
    • ,
  • Colin D Johnson, University of Southampton
    • ,
  • Alexandra Gilbert, University of Leeds
    • ,
  • Anne-Sophie Darlington, University of Southampton
    • ,
  • Kim Cocks, KCStats Consultancy
    • ,
  • Marianne G Guren, University of Oslo
    • ,
  • Eleonor Rivin Del Campo, Sorbonne Université
    • ,
  • Christine Brannan, Mount Vernon Cancer Centre
    • ,
  • Peter Christensen
  • William Chu, University of Toronto
    • ,
  • Hans Chung, University of Toronto
    • ,
  • Kristopher Dennis, University of Ottawa
    • ,
  • Isacco Desideri, University of Florence
    • ,
  • Duncan C Gilbert, Royal Sussex County Hospital, Brighton, UK.
    • ,
  • Rob Glynne-Jones, Mount Vernon Cancer Centre
    • ,
  • Michael Jefford, University of Melbourne
    • ,
  • Mia Johansson, Gothenburg Museum of Natural History, Gothenburg, Sweden.
    • ,
  • Anders Johnsson, Lund University
    • ,
  • Therese Juul
  • Dimitrios Kardamakis, University of Patras
    • ,
  • Julia Lai-Kwon, Uppsala University
    • ,
  • Vicky McFarlane, University of Southampton
    • ,
  • Isalia M C Miguel, University of Porto
    • ,
  • Karen Nugent, University of Southampton
    • ,
  • Femke Peters, Netherlands Cancer Institute
    • ,
  • Rachel P Riechelmann, AC Camargo Canc Ctr, A.C.Camargo Cancer Center
    • ,
  • Nazim S Turhal, Anadolu Medical Center
    • ,
  • Shun Wong, University of Toronto
    • ,
  • Vassilios Vassiliou, Bank of Cyprus Oncology Center
    • ,
  • European Organisation for Research and Treatment of Cancer Quality of Life Group

PURPOSE: The European Organisation for Research and Treatment of Cancer (EORTC) health-related quality of life questionnaire for anal cancer (QLQ-ANL27) supplements the EORTC cancer generic measure (QLQ-C30) to measure concerns specific to people with anal cancer treated with chemoradiotherapy. This study tested the psychometric properties and acceptability of the QLQ-ANL27.

METHODS AND MATERIALS: People with anal cancer were recruited from 15 countries to complete the QLQ-C30 and QLQ-ANL27 and provide feedback on the QLQ-ANL27. Item responses, scale structure (multitrait scaling, factor analysis), reliability (internal consistency and reproducibility) and sensitivity (known group comparisons and responsiveness to change) of the QLQ-ANL27 were evaluated.

RESULTS: Data from 382 people were included in the analyses. The EORTC QLQ-ANL27 was acceptable, comprehensive, and easy to complete, taking an average 8 minutes to complete. Psychometric analyses supported the EORTC QLQ-ANL27 items and reliability (Cronbach's α ranging from 0.71-0.93 and test-retest coefficients above 0.7) and validity of the scales (particularly nonstoma bowel symptoms and pain/discomfort). Most scales distinguished people according to treatment phase and performance status. Bowel (nonstoma), pain/discomfort, and vaginal symptoms were sensitive to deteriorations over time. The stoma-related scales remained untested because of low numbers of people with a stoma. Revisions to the scoring and question ordering of the sexual items were proposed.

CONCLUSIONS: The QLQ-ANL27 has good psychometric properties and is available in 16 languages for people treated with chemoradiotherapy for anal cancer. It is used in clinical trials and has a potential role in clinical practice.

OriginalsprogEngelsk
TidsskriftInternational Journal of Radiation Oncology, Biology, Physics
Vol/bind115
Nummer5
Sider (fra-til)1155-1164
Antal sider10
ISSN0360-3016
DOI
StatusUdgivet - apr. 2023

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