Interindividual variation in binding of benzo[a]pyrene to DNA in cultured human Bronchi

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • C.C. Harris, Danmark
  • Herman Autrup
  • R. Connor, Danmark
  • L.A. Barrett, Danmark
  • E.M. McDowell, Danmark
  • B.F. Trump, Danmark
  • Afdeling for Miljø- og Arbejdsmedicin
The binding of benzo[a]pyrene to DNA in cultured human bronchus was measured in specimens from 37 patients. The binding values ranged from 2 to 151 picomoles of benzo[a]pyrene per milligram of DNA with an overall mean +/- standard error of 34.2 +/- 5.2. This 75-fold interindividual variation in the binding of benzo[a]pyrene to DNA is similar in magnitude to that found in pharmacogenetic studies of drug metabolism. Aryl hydrocarbon hydroxylase is also inducible by benz[a]anthracene in the bronchial mucosa.
OriginalsprogEngelsk
TidsskriftScience
Vol/bind194
Nummer4269
Sider (fra-til)1067-1069
Antal sider3
ISSN0036-8075
StatusUdgivet - 3 dec. 1976

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