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Integrator is a genome-wide attenuator of non-productive transcription

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

DOI

  • Søren Lykke-Andersen
  • Kristina Žumer, Max Planck Institute for Biophysical Chemistry, Göttingen
    • ,
  • Ewa Šmidová Molska
    • ,
  • Jérôme O. Rouvière
  • Guifen Wu
  • Carina Demel, Max Planck Institute for Biophysical Chemistry, Göttingen
    • ,
  • Björn Schwalb, Max Planck Institute for Biophysical Chemistry, Göttingen
    • ,
  • Manfred Schmid
    • ,
  • Patrick Cramer, Max Planck Institute for Biophysical Chemistry, Göttingen
    • ,
  • Torben Heick Jensen

Metazoan RNA polymerase II activity is promiscuous within and outside of conventional genes. Lykke-Andersen et al. show that cleavage and polyadenylation (CPA) and integrator (INT) transcription termination complexes operate genome-wide in sequence- and context-dependent manners, respectively. The INT complex is suggested to take part in quality control of non-productive transcription.

OriginalsprogEngelsk
TidsskriftMolecular Cell
Vol/bind81
Nummer3
Sider (fra-til)514-529.e6
Antal sider23
ISSN1097-2765
DOI
StatusUdgivet - feb. 2021

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