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Integrator is a genome-wide attenuator of non-productive transcription
Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
DOI
- https://doi.org/10.1016/j.molcel.2020.12.014
Forlagets udgivne version
- Søren Lykke-Andersen
- Kristina Žumer, Max Planck Institute for Biophysical Chemistry, Göttingen ,
- Ewa Šmidová Molska ,
- Jérôme O. Rouvière
- Guifen Wu
- Carina Demel, Max Planck Institute for Biophysical Chemistry, Göttingen ,
- Björn Schwalb, Max Planck Institute for Biophysical Chemistry, Göttingen ,
- Manfred Schmid
- Patrick Cramer, Max Planck Institute for Biophysical Chemistry, Göttingen ,
- Torben Heick Jensen
Metazoan RNA polymerase II activity is promiscuous within and outside of conventional genes. Lykke-Andersen et al. show that cleavage and polyadenylation (CPA) and integrator (INT) transcription termination complexes operate genome-wide in sequence- and context-dependent manners, respectively. The INT complex is suggested to take part in quality control of non-productive transcription.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Molecular Cell |
| Vol/bind | 81 |
| Nummer | 3 |
| Sider (fra-til) | 514-529.e6 |
| Antal sider | 23 |
| ISSN | 1097-2765 |
| DOI | |
| Status | Udgivet - feb. 2021 |
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