Integrator is a genome-wide attenuator of non-productive transcription

Søren Lykke-Andersen*, Kristina Žumer, Ewa Šmidová Molska, Jérôme O. Rouvière, Guifen Wu, Carina Demel, Björn Schwalb, Manfred Schmid, Patrick Cramer*, Torben Heick Jensen*

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Abstract

Metazoan RNA polymerase II activity is promiscuous within and outside of conventional genes. Lykke-Andersen et al. show that cleavage and polyadenylation (CPA) and integrator (INT) transcription termination complexes operate genome-wide in sequence- and context-dependent manners, respectively. The INT complex is suggested to take part in quality control of non-productive transcription.

OriginalsprogEngelsk
TidsskriftMolecular Cell
Vol/bind81
Nummer3
Sider (fra-til)514-529.e6
Antal sider23
ISSN1097-2765
DOI
StatusUdgivet - feb. 2021

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