TY - JOUR
T1 - Integrative physiology of lysine metabolites
AU - Tan, Yifan
AU - Chrysopoulou, Maria
AU - Rinschen, Markus M.
PY - 2023/12
Y1 - 2023/12
N2 - Lysine is an essential amino acid that serves as a building block in protein synthesis. Beside this, the metabolic activity of lysine has only recently been unraveled. Lysine metabolism is tissue specific and is linked to several renal, cardiovascular, and endocrinological diseases through human metabolomics datasets. As a free molecule, lysine takes part in the antioxidant response and engages in protein modifications, and its chemistry shapes both proteome and metabolome. In the proteome, it is an acceptor for a plethora of posttranslational modifications. In the metabolome, it can be modified, conjugated, and degraded. Here, we provide an update on integrative physiology of mammalian lysine metabolites such as a-aminoadipic acid, saccharopine, pipecolic acid, and lysine conjugates such as acetyl-lysine, and sugar-lysine conjugates such as advanced glycation end products. We also comment on their emerging associative and mechanistic links to renal disease, hypertension, diabetes, and cancer.
AB - Lysine is an essential amino acid that serves as a building block in protein synthesis. Beside this, the metabolic activity of lysine has only recently been unraveled. Lysine metabolism is tissue specific and is linked to several renal, cardiovascular, and endocrinological diseases through human metabolomics datasets. As a free molecule, lysine takes part in the antioxidant response and engages in protein modifications, and its chemistry shapes both proteome and metabolome. In the proteome, it is an acceptor for a plethora of posttranslational modifications. In the metabolome, it can be modified, conjugated, and degraded. Here, we provide an update on integrative physiology of mammalian lysine metabolites such as a-aminoadipic acid, saccharopine, pipecolic acid, and lysine conjugates such as acetyl-lysine, and sugar-lysine conjugates such as advanced glycation end products. We also comment on their emerging associative and mechanistic links to renal disease, hypertension, diabetes, and cancer.
KW - lysine
KW - metabolism
UR - http://www.scopus.com/inward/record.url?scp=85177453206&partnerID=8YFLogxK
U2 - 10.1152/physiolgenomics.00061.2023
DO - 10.1152/physiolgenomics.00061.2023
M3 - Review
C2 - 37781739
AN - SCOPUS:85177453206
SN - 1094-8341
VL - 55
SP - 579
EP - 586
JO - Physiological Genomics
JF - Physiological Genomics
IS - 12
ER -