Integrative analyses of gene expression and DNA methylation profiles in breast cancer cell line models of tamoxifen-resistance indicate a potential role of cells with stem-like properties

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  • Xue Lin
  • Jian Li
  • Guangliang Yin
  • ,
  • Qian Zhao
  • ,
  • Daniel Elias, Ditzel-gruppen, Danmark
  • Anne E Lykkesfeldt, Danmark
  • Jan Stenvang, 2012 Faggruppe Patobiologi, Danmark
  • Nils Brünner, Danmark
  • Jun Wang, Danmark
  • Huanming Yang
  • ,
  • Lars Bolund
  • Henrik J Ditzel, Danmark
Development of resistance to tamoxifen is an important clinical issue in the treatment of breast cancer. Tamoxifen resistance may be the result of acquisition of epigenetic regulation within breast cancer cells, such as DNA methylation, resulting in changed mRNA expression of genes pivotal for estrogen-dependent growth. Alternatively, tamoxifen resistance may be due to selection of pre-existing resistant cells, or a combination of the two mechanisms.
OriginalsprogEngelsk
TidsskriftBreast Cancer Research (Online Edition)
Vol/bind15
Nummer6
Sider (fra-til)R119
ISSN1465-5411
DOI
StatusUdgivet - 19 dec. 2013

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