Intake of α-linolenic acid is not consistently associated with a lower risk of peripheral artery disease: results from a Danish cohort study

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  • Christian S Bork, Kardiologisk Afdeling, Aalborg Sygehus, Human Development & Health, Faculty of Medicine,University of Southampton,MP887 Southampton General Hospital, Tremona Road, Southampton SO16 6YD,United Kingdom., Danmark
  • Anne Northmann Lasota, Department of Vascular Surgery,Aalborg University Hospital,Hobrovej 18-22, 9000 Aalborg,Denmark., Department of Clinical Medicine, Aalborg University Hospital, Danmark
  • Søren Lundbye-Christensen, Unit of Clinical Biostatistics, Aalborg University Hospital, Denmark.
  • ,
  • Marianne U Jakobsen, Division for Diet, Disease Prevention and Toxicology, National Food Institute, Technical University of Denmark, Kemitorvet 2, 2800, Kgs. Lyngby, Denmark.
  • ,
  • Anne Tjønneland, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen 2100, Denmark., Danmark
  • Philip C Calder, Human Development & Health, Faculty of Medicine,University of Southampton,MP887 Southampton General Hospital, Tremona Road, Southampton SO16 6YD,United Kingdom., Storbritannien
  • Erik B Schmidt, Department of Clinical Medicine, Aalborg University Hospital
  • ,
  • Kim Overvad

Intake of the plant-derived omega-3 fatty acid alpha-linolenic acid (ALA) has been associated with anti-atherosclerotic properties. However, information on the association between ALA intake and development of peripheral artery disease (PAD) is lacking. In this follow-up study, we investigated the association between dietary intake of ALA and the rate of PAD among middle-aged Danish men and women enrolled into the Danish Diet, Cancer and Health cohort between 1993 and 1997. Incident PAD cases were identified through the Danish National Patient Register. Intake of ALA was assessed using a validated food frequency questionnaire. Statistical analyses were performed using Cox proportional hazard regression allowing for separate baseline hazards among sexes and adjusted for established risk factors for PAD. During a median of 13.6 years of follow-up, we identified 950 valid cases of PAD with complete information on covariates. The median energy-adjusted ALA intake within the cohort was 1.76 g/d (95% central range: 0.94-3.28). In multivariable analyses, we found no statistically significant association between intake of ALA and the rate of PAD (P = 0.339). Also, no statistically significant associations were observed in analyses including additional adjustment for co-morbidities and in sex-specific analyses. In supplemental analyses with additional adjustment for potential dietary risk factors, we found a weak inverse association to PAD with ALA intake above the median, but the association was not statistically significant (P = 0.314). In conclusion, dietary intake of ALA was not consistently associated with decreased risk of PAD.

OriginalsprogEngelsk
TidsskriftThe British Journal of Nutrition
Vol/bind122
Nummer1
Sider (fra-til)86-92
Antal sider7
ISSN0007-1145
DOI
StatusUdgivet - jul. 2019

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