Intake of Individual Fatty Acids and Risk of Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition

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  • Aurora Perez-Cornago, Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, United Kingdom., Storbritannien
  • Inge Huybrechts, Dietary Exposure Assessment Group, International Agency for Research on Cancer, Lyon, France., Frankrig
  • Paul N Appleby, Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, United Kingdom., Storbritannien
  • Julie A Schmidt, Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, United Kingdom.
  • ,
  • Francesca L Crowe, Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom., Storbritannien
  • Kim Overvad
  • Anne Tjønneland, Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark., Danmark
  • Tilman Kühn, Division of Cancer Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany., Tyskland
  • Verena Katzke, Division of Cancer Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany., Tyskland
  • Antonia Trichopoulou, Hellenic Health Foundation, Athens, Greece., Grækenland
  • Anna Karakatsani, Pulmonary Medicine Dept., School of Medicine, National and Kapodistrian University of Athens, "ATTIKON" University Hospital, Haidari, Greece., Hellenic Health Foundation, Athens, Grækenland
  • Eleni Peppa, Hellenic Health Foundation, Athens, Greece., Grækenland
  • Sara Grioni, Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milano, Italy., Italien
  • Domenico Palli, Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, ISPRO, Florence, Italy., Italien
  • Carlotta Sacerdote, Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and Center for Cancer Prevention (CPO), Turin, Italy., Italien
  • Rosario Tumino, Cancer Registry and Histopathology Department, "Civic M.P. Arezzo" Hospital, ASP, Ragusa, Italy., Italien
  • H Bas Bueno-de-Mesquita, National Institute for Public Health and the Environment (RIVM), Bilthoven, University Medical Centre Utrecht, Imperial College London, University of Malaya, Malaysia
  • Nerea Larrañaga, CIBER Epidemiology and Public Health CIBERESP, Melchor Fernández Almagro 3-5, Madrid 28029, Spain., Public Health Division of Gipuzkoa-BIODONOSTIA, Basque Regional Health Department, Donostia, Spanien
  • Maria-Jose Sánchez, Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada/Universidad de Granada, 18014 Granada, Spain., CIBER of Epidemiology and Public Health (CIBERESP), Spain., Spanien
  • J Ramón Quirós, Public Health Directorate, Asturias, Spain., Spanien
  • Eva Ardanaz, IdiSNA, Navarra Institute for Health Research, Pamplona, Spain., CIBER of Epidemiology and Public Health (CIBERESP), Spain., Navarra Public Health Institute, c/Leyre 15, Pamplona 31003, Pamplona, Spain., Spanien
  • María-Dolores Chirlaque, Department of Epidemiology, Murcia Regional Health Authority, Murcia, Spain; Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain., CIBER of Epidemiology and Public Health (CIBERESP), Spain., Spanien
  • Antonio Agudo, Unit of Nutrition and Cancer. Cancer Epidemiology Research Program. Catalan Institute of Oncology-IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain., Spanien
  • Anders Bjartell, Department of Urology Skåne University Hospital, Malmö, Sweden., Lund University, Sverige
  • Peter Wallström, Department of Clinical Sciences, Malmö Clinical Research Centre, Lund University, Skåne University Hospital, SE-205 02, Malmö, Sweden., Sverige
  • Veronique Chajes, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), Lyon, France., Frankrig
  • Konstantinos K Tsilidis, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom, University of Ioannina, Storbritannien
  • Dagfinn Aune, Department of Clinical Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Institute of Clinical Medicine, Oslo University, Oslo, Norway., Bjørknes University College, Oslo, Norway., Imperial College London, Norge
  • Elio Riboli, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom, Storbritannien
  • Ruth C Travis, Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, United Kingdom., Storbritannien
  • Timothy J Key, Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, United Kingdom., Storbritannien

The associations of individual dietary fatty acids with prostate cancer risk have not been examined comprehensively. We examined the prospective association of individual dietary fatty acids with prostate cancer risk overall, by tumor subtypes, and prostate cancer death. 142,239 men from the European Prospective Investigation into Cancer and Nutrition who were free from cancer at recruitment were included. Dietary intakes of individual fatty acids were estimated using center-specific validated dietary questionnaires at baseline and calibrated with 24-hour recalls. Multivariable Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). After an average follow-up of 13.9 years, 7,036 prostate cancer cases and 936 prostate cancer deaths were ascertained. Intakes of individual fatty acids were not related to overall prostate cancer risk. There was evidence of heterogeneity in the association of some short chain saturated fatty acids with prostate cancer risk by tumor stage (Pheterogeneity <0.015), with a positive association with risk of advanced stage disease for butyric acid (4:0; HR1SD =1.08; 95%CI=1.01-1.15; P-trend=0.026). There were no associations with fatal prostate cancer, with the exception of a slightly higher risk for those who consumed more eicosenoic acid (22:1n-9c; HR1SD =1.05; 1.00-1.11; P-trend=0.048) and eicosapentaenoic acid (20:5n-3c; HR1SD =1.07; 1.00-1.14; P-trend=0.045). There was no evidence that dietary intakes of individual fatty acids were associated with overall prostate cancer risk. However, a higher intake of butyric acid might be associated with a higher risk of advanced, whereas intakes of eicosenoic and eicosapentaenoic acids might be positively associated with fatal prostate cancer risk. This article is protected by copyright. All rights reserved.

OriginalsprogEngelsk
TidsskriftInternational Journal of Cancer
Vol/bind146
Nummer1
Sider (fra-til)44-57
Antal sider14
ISSN0020-7136
DOI
StatusUdgivet - jan. 2020

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This article is protected by copyright. All rights reserved.

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