Instantaneous wave-free ratio guided multivessel revascularisation during percutaneous coronary intervention for acute myocardial infarction: study protocol of the randomised controlled iMODERN trial

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Instantaneous wave-free ratio guided multivessel revascularisation during percutaneous coronary intervention for acute myocardial infarction : study protocol of the randomised controlled iMODERN trial. / Beijnink, Casper W H; Thim, Troels; van der Heijden, Dirk Jan; Klem, Igor; Al-Lamee, Rasha; Vos, Jacqueline L; Koop, Yvonne; Dijkgraaf, Marcel G W; Beijk, Marcel A M; Kim, Raymond J; Davies, Justin; Raposo, Luis; Baptista, Sérgio B; Escaned, Javier; Piek, Jan J; Maeng, Michael; van Royen, Niels; Nijveldt, Robin.

I: BMJ Open, Bind 11, Nr. 1, e044035, 01.2021.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Beijnink, CWH, Thim, T, van der Heijden, DJ, Klem, I, Al-Lamee, R, Vos, JL, Koop, Y, Dijkgraaf, MGW, Beijk, MAM, Kim, RJ, Davies, J, Raposo, L, Baptista, SB, Escaned, J, Piek, JJ, Maeng, M, van Royen, N & Nijveldt, R 2021, 'Instantaneous wave-free ratio guided multivessel revascularisation during percutaneous coronary intervention for acute myocardial infarction: study protocol of the randomised controlled iMODERN trial', BMJ Open, bind 11, nr. 1, e044035. https://doi.org/10.1136/bmjopen-2020-044035

APA

Beijnink, C. W. H., Thim, T., van der Heijden, D. J., Klem, I., Al-Lamee, R., Vos, J. L., Koop, Y., Dijkgraaf, M. G. W., Beijk, M. A. M., Kim, R. J., Davies, J., Raposo, L., Baptista, S. B., Escaned, J., Piek, J. J., Maeng, M., van Royen, N., & Nijveldt, R. (2021). Instantaneous wave-free ratio guided multivessel revascularisation during percutaneous coronary intervention for acute myocardial infarction: study protocol of the randomised controlled iMODERN trial. BMJ Open, 11(1), [e044035]. https://doi.org/10.1136/bmjopen-2020-044035

CBE

Beijnink CWH, Thim T, van der Heijden DJ, Klem I, Al-Lamee R, Vos JL, Koop Y, Dijkgraaf MGW, Beijk MAM, Kim RJ, Davies J, Raposo L, Baptista SB, Escaned J, Piek JJ, Maeng M, van Royen N, Nijveldt R. 2021. Instantaneous wave-free ratio guided multivessel revascularisation during percutaneous coronary intervention for acute myocardial infarction: study protocol of the randomised controlled iMODERN trial. BMJ Open. 11(1):Article e044035. https://doi.org/10.1136/bmjopen-2020-044035

MLA

Vancouver

Author

Beijnink, Casper W H ; Thim, Troels ; van der Heijden, Dirk Jan ; Klem, Igor ; Al-Lamee, Rasha ; Vos, Jacqueline L ; Koop, Yvonne ; Dijkgraaf, Marcel G W ; Beijk, Marcel A M ; Kim, Raymond J ; Davies, Justin ; Raposo, Luis ; Baptista, Sérgio B ; Escaned, Javier ; Piek, Jan J ; Maeng, Michael ; van Royen, Niels ; Nijveldt, Robin. / Instantaneous wave-free ratio guided multivessel revascularisation during percutaneous coronary intervention for acute myocardial infarction : study protocol of the randomised controlled iMODERN trial. I: BMJ Open. 2021 ; Bind 11, Nr. 1.

Bibtex

@article{a0dbbd32500c45dd9c6b04403bfad7d6,
title = "Instantaneous wave-free ratio guided multivessel revascularisation during percutaneous coronary intervention for acute myocardial infarction: study protocol of the randomised controlled iMODERN trial",
abstract = "INTRODUCTION: Recent randomised clinical trials showed benefit of non-culprit lesion revascularisation in ST-elevation myocardial infarction (STEMI) patients. However, it remains unclear whether revascularisation should be performed at the index procedure or at a later stage.METHODS AND ANALYSIS: The instantaneous wave-free ratio (iFR) Guided Multivessel Revascularisation During Percutaneous Coronary Intervention for Acute Myocardial Infarction trial is a multicentre, randomised controlled prospective open-label trial with blinded evaluation of endpoints. After successful primary percutaneous coronary intervention (PCI), eligible STEMI patients with residual non-culprit lesions are randomised, to instantaneous wave-free ratio guided treatment of non-culprit lesions during the index procedure versus deferred cardiac MR-guided management within 4 days to 6 weeks. The primary endpoint of the study is the combined occurrence of all-cause death, recurrent myocardial infarction and hospitalisation for heart failure at 12 months follow-up. Clinical follow-up includes questionnaires at 3 months and outpatient visits at 6 months and 12 months after primary PCI. Furthermore, a cost-effectiveness analysis will be performed.ETHICS AND DISSEMINATION: Permission to conduct this trial has been granted by the Medical Ethical Committee of the Amsterdam University Medical Centres (loc. VUmc, ID NL60107.029.16). The primary results of this trial will be shared in a main article and subgroup analyses or spin-off studies will be shared in secondary papers.TRIAL REGISTRATION NUMBER: NCT03298659.",
keywords = "coronary heart disease, coronary intervention, ischaemic heart disease, magnetic resonance imaging, myocardial infarction",
author = "Beijnink, {Casper W H} and Troels Thim and {van der Heijden}, {Dirk Jan} and Igor Klem and Rasha Al-Lamee and Vos, {Jacqueline L} and Yvonne Koop and Dijkgraaf, {Marcel G W} and Beijk, {Marcel A M} and Kim, {Raymond J} and Justin Davies and Luis Raposo and Baptista, {S{\'e}rgio B} and Javier Escaned and Piek, {Jan J} and Michael Maeng and {van Royen}, Niels and Robin Nijveldt",
note = "{\textcopyright} Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2021",
month = jan,
doi = "10.1136/bmjopen-2020-044035",
language = "English",
volume = "11",
journal = "B M J Open",
issn = "2044-6055",
publisher = "BMJ Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Instantaneous wave-free ratio guided multivessel revascularisation during percutaneous coronary intervention for acute myocardial infarction

T2 - study protocol of the randomised controlled iMODERN trial

AU - Beijnink, Casper W H

AU - Thim, Troels

AU - van der Heijden, Dirk Jan

AU - Klem, Igor

AU - Al-Lamee, Rasha

AU - Vos, Jacqueline L

AU - Koop, Yvonne

AU - Dijkgraaf, Marcel G W

AU - Beijk, Marcel A M

AU - Kim, Raymond J

AU - Davies, Justin

AU - Raposo, Luis

AU - Baptista, Sérgio B

AU - Escaned, Javier

AU - Piek, Jan J

AU - Maeng, Michael

AU - van Royen, Niels

AU - Nijveldt, Robin

N1 - © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2021/1

Y1 - 2021/1

N2 - INTRODUCTION: Recent randomised clinical trials showed benefit of non-culprit lesion revascularisation in ST-elevation myocardial infarction (STEMI) patients. However, it remains unclear whether revascularisation should be performed at the index procedure or at a later stage.METHODS AND ANALYSIS: The instantaneous wave-free ratio (iFR) Guided Multivessel Revascularisation During Percutaneous Coronary Intervention for Acute Myocardial Infarction trial is a multicentre, randomised controlled prospective open-label trial with blinded evaluation of endpoints. After successful primary percutaneous coronary intervention (PCI), eligible STEMI patients with residual non-culprit lesions are randomised, to instantaneous wave-free ratio guided treatment of non-culprit lesions during the index procedure versus deferred cardiac MR-guided management within 4 days to 6 weeks. The primary endpoint of the study is the combined occurrence of all-cause death, recurrent myocardial infarction and hospitalisation for heart failure at 12 months follow-up. Clinical follow-up includes questionnaires at 3 months and outpatient visits at 6 months and 12 months after primary PCI. Furthermore, a cost-effectiveness analysis will be performed.ETHICS AND DISSEMINATION: Permission to conduct this trial has been granted by the Medical Ethical Committee of the Amsterdam University Medical Centres (loc. VUmc, ID NL60107.029.16). The primary results of this trial will be shared in a main article and subgroup analyses or spin-off studies will be shared in secondary papers.TRIAL REGISTRATION NUMBER: NCT03298659.

AB - INTRODUCTION: Recent randomised clinical trials showed benefit of non-culprit lesion revascularisation in ST-elevation myocardial infarction (STEMI) patients. However, it remains unclear whether revascularisation should be performed at the index procedure or at a later stage.METHODS AND ANALYSIS: The instantaneous wave-free ratio (iFR) Guided Multivessel Revascularisation During Percutaneous Coronary Intervention for Acute Myocardial Infarction trial is a multicentre, randomised controlled prospective open-label trial with blinded evaluation of endpoints. After successful primary percutaneous coronary intervention (PCI), eligible STEMI patients with residual non-culprit lesions are randomised, to instantaneous wave-free ratio guided treatment of non-culprit lesions during the index procedure versus deferred cardiac MR-guided management within 4 days to 6 weeks. The primary endpoint of the study is the combined occurrence of all-cause death, recurrent myocardial infarction and hospitalisation for heart failure at 12 months follow-up. Clinical follow-up includes questionnaires at 3 months and outpatient visits at 6 months and 12 months after primary PCI. Furthermore, a cost-effectiveness analysis will be performed.ETHICS AND DISSEMINATION: Permission to conduct this trial has been granted by the Medical Ethical Committee of the Amsterdam University Medical Centres (loc. VUmc, ID NL60107.029.16). The primary results of this trial will be shared in a main article and subgroup analyses or spin-off studies will be shared in secondary papers.TRIAL REGISTRATION NUMBER: NCT03298659.

KW - coronary heart disease

KW - coronary intervention

KW - ischaemic heart disease

KW - magnetic resonance imaging

KW - myocardial infarction

UR - http://www.scopus.com/inward/record.url?scp=85099559358&partnerID=8YFLogxK

U2 - 10.1136/bmjopen-2020-044035

DO - 10.1136/bmjopen-2020-044035

M3 - Journal article

C2 - 33452200

VL - 11

JO - B M J Open

JF - B M J Open

SN - 2044-6055

IS - 1

M1 - e044035

ER -