Aarhus Universitets segl

Injection of freshly collected autologous adipose tissue in complicated pilonidal disease: a prospective pilot study

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  • Vestergaard G. Sophie, Aarhus Universitet
  • ,
  • Sørensen J. Marlene, Aarhus Universitet
  • ,
  • Hougaard T. Helene
  • Lundby Lilli
  • ,
  • Pedersen G. Allan, Aarhus Universitet
  • ,
  • Haas Susanne

Background: Pilonidal sinus disease (PSD) is a frequent disorder. Treatment failure and recurrence are common, leading to significant morbidity. The aim of this study was to investigate the impact and need for repeated treatment of injected autologous adipose tissue into non-healing PSD wounds and primary anal-near PSD or anal-near recurrence. Methods: At the Department of Surgery, Randers Regional Hospital, Denmark, a prospective pilot study was conducted on consecutive PSD patients with lack of healing 3 months after surgery (Bascom’s cleft lift) or with primary or recurrent anal-near pilonidal sinus disease from December 2018 to March 2020. The primary endpoint was time to healing. Autologous adipose tissue was harvested from the patients and injected into the lesions after surgical revision. Patients were examined 2 and 12 weeks after surgery. Patients with lack of healing after 12 weeks (undermining or no skin coverage) were offered re-injection. Results: We included 30 patients [26 men and 4 women, median age 24 years (range 18–59 years)]. Complete healing was achieved in 25 patients [83.3%; 95% CI (69.9–96.7)]. Two patients had recurrence (6.7%). The median time to complete healing was 159 (189) days. The mean operation time was 70.6 ± 23.7 min and the mean amount of injected autologous adipose tissue was 19 ± 10 ml. There were no major complications. Conclusion: Freshly collected autologous adipose tissue injected into chronic non-healing or primary and recurrent PSD lesions near the anal verge is safe and efficient.

TidsskriftTechniques in Coloproctology
Sider (fra-til)883-891
Antal sider9
StatusUdgivet - nov. 2022

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