Inflammatory potential of the diet and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study

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  • P Jakszyn, Facultat de Ciències de la Salut Blanquerna, Universitat Ramon Llull, Barcelona, Spain., Spanien
  • V Cayssials, Department of Biostatistics and Informatics, Institute for Bioscience, University of the Republic, Montevideo, Uruguay., Uruguay
  • G Buckland, Center for Academic Child Health, Bristol Medical School, University of Bristol, 1-5 Whiteladies Road, Bristol., Storbritannien
  • A Perez-Cornago, Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, United Kingdom., Storbritannien
  • E Weiderpass, Biostatistics Group, International Agency for Research on Cancer, Lyon, France., Frankrig
  • H Boeing, Department of Epidemiology, German Institute of Human Nutrition (DIfE) Postdam-Rehbrücke, Nuthetal, Germany., Tyskland
  • M M Bergmann, Department of Epidemiology, German Institute of Human Nutrition (DIfE) Postdam-Rehbrücke, Nuthetal, Germany., Tyskland
  • A Vulcan, Department of Clinical Sciences, Lund University, Department of Gastroenterology and Nutrition, Skåne University Hospital, Malmö, Sweden., Sverige
  • B Ohlsson, Department of Clinical Sciences, Division of Internal Medicine, Skåne University Hospital, Malmö, Lund University, Lund, Sweden., Sverige
  • G Masala, Cancer Risk Factors and Life-Style Epidemiology Unit. Institute for Cancer Research, Prevention and Clinical Network - ISPRO, 50141, Florence, Italy., Italien
  • A J Cross, Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, W2 1NY London, UK., Storbritannien
  • E Riboli, Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, W2 1NY London, UK., Storbritannien
  • F Ricceri, Unit of Epidemiology, Regional Health Service ASL TO3, Grugliasco (TO), Italy., Italien
  • C Dahm
  • D Nyvang, Institut for Folkesundhed, Aarhus Universitet, Danmark
  • V A Katzke, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. r.kaaks@dkfz-heidelberg.de., Tyskland
  • T Kühns, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. r.kaaks@dkfz-heidelberg.de., Tyskland
  • C Kyrø, Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark., Danmark
  • A Tjønneland, Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark., Danmark
  • H A Ward, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, 45110, Greece., Grækenland
  • K K Tsilidis, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, 45110, Greece., Grækenland
  • G Skeie, Nutritional Epidemiology Group, School of Food Science and Nutrition, University of Leeds, Leeds, UK., Storbritannien
  • S Sieri, Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian, 1, 20133 Milano, Italy., Italien
  • M J Sanchez, Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Spain; CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain., Spanien
  • J M Huerta, Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain., Spanien
  • P Amiano, Public Health Division of Gipuzko, BioDonostia Research institute, Donostia- San Sebastian, Spain., Spanien
  • C Lasheras, Department of Functional Biology, Faculty of Medicine, University of Oviedo, CP 33006 Oviedo, Asturias, Spain., Spanien
  • E Ardanaz, Navarre Public Health Institute, Pamplona, Navarra Institute for Health Research (IdiSNA), Pamplona, Spain., Spanien
  • Y Mahamat-Saleh, CESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, INSERM, Université Paris-Saclay, 94805, Villejuif, France; Gustave Roussy, F-94805, Villejuif, France., Frankrig
  • M C Boutron-Ruault, CESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, INSERM, Université Paris-Saclay, 94805, Villejuif, France; Gustave Roussy, F-94805, Villejuif, France., Frankrig
  • F Carbonnel, Department of Gastroenterology, Bicêtre University Hospital, Assistance Publique des Hôpitaux de Paris, Le Kremlin Bicêtre, France., Frankrig
  • S Panico, EPIC Centre of Naples. Dipartimento di Medicina Clinica e Chirurgia Federico II University, Naples, Italy., Italien
  • E Peppa, Hellenic Health Foundation, Athens, Greece., Grækenland
  • A Trichopoulou, Hellenic Health Foundation, Athens, Greece., Grækenland
  • A Karakatsani, Pulmonary Medicine Dept., School of Medicine, National and Kapodistrian University of Athens, "ATTIKON" University Hospital, Haidari, Greece., Grækenland
  • R Tumino, Cancer Registry and Histopathology Department, Civic M.P.Arezzo Hospital, Ragusa, Italy, Ragusa, Italy., Italien
  • R Vermeulen, 1] School of Public Health, Imperial College, London, UK [2] Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands., Holland
  • M Jenab, Biostatistics Group, International Agency for Research on Cancer, Lyon, France., Frankrig
  • M Gunter, Biostatistics Group, International Agency for Research on Cancer, Lyon, France.
  • ,
  • A Agudo, Unit of Nutrition and Cancer. Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain., Spanien

Pro-inflammatory diets are associated with risk of developing colorectal cancer (CRC), however inconsistencies exist in subsite- and sex-specific associations. The relationship between CRC and combined lifestyle-related factors that contribute towards a low-grade inflammatory profile has not yet been explored. We examined the association between the dietary inflammatory potential and an inflammatory profile and CRC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. This cohort included 476,160 participants followed-up of 14 years and 5,991 incident CRC cases (3,897 colon and 2,094 rectal tumours). Dietary inflammatory potential was estimated using an Inflammatory Score of the Diet (ISD). An Inflammatory Profile Score (IPS) was constructed, incorporating the ISD, physical activity level and abdominal obesity. The associations between the ISD and CRC and IPS and CRC were assessed using multivariable regression models. More pro- inflammatory diets were related to a higher CRC risk, particularly for colon cancer; Hazar Ratio (HR) for highest versus lowest ISD quartile was 1.15 (95% confidence interval (CI) 1.04-1.27) for CRC, 1.24 (95% CI 1.09-1.41) for colon cancer and 0.99 (95% CI 0.83-1.17) for rectal cancer. Associations were more pronounced in men and not significant in women. The IPS was associated with CRC risk, particularly colon cancer among men; HRs for the highest versus lowest IPS were 1.62 (95% CI 1.31- 2.01) for colon cancer overall and 2.11 (95% CI 1.50-2.97) for colon cancer in men. This study shows that more pro-inflammatory diets and a more inflammatory profile are associated with higher risk of CRC, principally colon cancer and in men. This article is protected by copyright. All rights reserved.

OriginalsprogEngelsk
TidsskriftInternational Journal of Cancer
Vol/bind147
Nummer4
Sider (fra-til)1027-1039
Antal sider13
ISSN0020-7136
DOI
StatusUdgivet - 2020

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This article is protected by copyright. All rights reserved.

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